Prognostic accuracy of myocardial perfusion imaging in octogenarians

Abstract

Use of MPI in octogenarians is associated with similar or better prognostic accuracy than in younger subjects.

Role of myocardial perfusion scintigraphy in octogenarians: Time for reappraisal?

“…As regards cardiac deaths, a constant and significantly increase from normal, mildly abnormal, and moderately-to-severely abnormal myocardial perfusion during pharmacologic stress (1.9% vs 2.7% vs 7.8%) or exercise stress (0.7% vs 1.0% vs 2.7%) was observed. Similarly, Nudi et al 1 demonstrated that the extent and severity of myocardial ischemia was also paralleled by a worsened cardiovascular outcome but the current study expands it now to octogenarians in a relatively high numbers of 517 individuals. Thus, current 1 and previous MPS studies 2,3,6,7 signify that MPS may indeed be of help in identifying elderly patients, even when exceeding 80 years, at risk for cardiovascular events.…”

“…Similarly, Nudi et al 1 demonstrated that the extent and severity of myocardial ischemia was also paralleled by a worsened cardiovascular outcome but the current study expands it now to octogenarians in a relatively high numbers of 517 individuals. Thus, current 1 and previous MPS studies 2,3,6,7 signify that MPS may indeed be of help in identifying elderly patients, even when exceeding 80 years, at risk for cardiovascular events. In particular, Nudi et al 1 could demonstrate with a propensity-matched analysis that the MPS-related diagnostic and prognostic accuracy was similar or even better in octogenarians than in younger patients.…”

“…These results of Nudi et al, 1 assessed in a retrospective fashion, contribute to further refine the role of MPS in octogenarians. Given the steady increase of elderly patients or individuals older than 75 years, MPS is likely to play a more central role in these elderly patients for the detection of hemodynamic and prognostic relevant CAD.…”

“…Thus, current 1 and previous MPS studies 2,3,6,7 signify that MPS may indeed be of help in identifying elderly patients, even when exceeding 80 years, at risk for cardiovascular events. In particular, Nudi et al 1 could demonstrate with a propensity-matched analysis that the MPS-related diagnostic and prognostic accuracy was similar or even better in octogenarians than in younger patients. This novel observation may be surprising at first sight but is likely to be reconciled with observed more advanced and diffuse CAD on invasive coronary angiography in octogenarians than in the younger population.…”

“…Nudi et al 1 should be congratulated for their work to appraise the use of myocardial perfusion scintigraphy (MPS) for prognostication in octogenarians. The authors performed a retrospective and single-center evaluation of 13,254 patients undergoing MPS.…”