Prognosis Value of Plasma S100B Protein Levels after Subarachnoid Aneurysmal Hemorrhage

Abstract

Mean daily value of S100B assessed during the first 8 days is a prognostic tool complementary to initial clinical evaluation in subarachnoid hemorrhage patients.

Prognostic Value of Serum S100 Protein by Elecsys S100 Immunoassay in Patients with Spontaneous Subarachnoid and Intracerebral Hemorrhages

“…In SAH patients, S100 protein level correlated with neurological status at admission (high Hunt & Hess grade and Fisher grade) and outcome by many authors 17,[21][22][23] . But, in this study admission S100 protein level showed a tendency to correlate with initial clinical status measured by GCS score, not by Hunt & Hess grade, probably because GCS score was more sensitive to reflect the clinical status than Hunt & Hess grade.…”

“…Even though the prognostic value of S100 protein has been extensively studied in severe head injury, acute ischemic stroke and cardiac arrest, S100 protein in patient with SAH was less frequently studied 2,3,6,13,16,17,19,[21][22][23] . Furthermore, the role of S100 protein in patient with ICH is lacking 5) .…”

“…It has two subunits of alpha and beta. S100 beta or S100B has been known to be released from the damaged astrocyte in various conditions, such as cerebral infarction, head injury, less frequently spontaneous subarachnoid hemorrhage (SAH) and intracerebral hemorrhage (ICH) and reflect the severity of neuronal damage 5,6,9,11,12,19,22) .…”

“…An early concentration peak of S100 in serum 20 minutes after brain damage seems to reflect both cellular damage and increased permeability of the BBB 2) . Several sensitive assays for the detection of serum S100B have become available 1,15,16,20,22) . Of these, Liaison Sangtec 100 method and Liamat method were commonly used for detection of S100B 18 min over previous LIA-mat S100 system, which requires over 2 hours 6) .…”

Neopterin plasma concentrations in patients with aneurysmal subarachnoid hemorrhage: correlation with infection and long-term outcome

“…Increased concentrations of S100 calcium binding proteinb (S100b), C-reactive protein, adhesion and matrix molecules, and vasogenic and cardiac markers have been found in aSAH patients with poor outcomes, but the limited accuracy of most of these markers has hampered their use in clinical practice. 13,27,36,38 Neopterin, a catabolic product of GTP (guanosine-5-triphosphate) produced by human monocytes-macrophages upon stimulation with interferon-g, has been reported as an outcome and infection biomarker for several inflammatory diseases. 6,19,35 Moreover, Mathiesen et al showed that the CSF and plasma concentrations of neopterin were higher in patients suffering from aSAH than in controls.…”