Prognosis value of IL-6, IL-8, and IL-1β in serum of patients with lung cancer: A fresh look at interleukins as a biomarker

Yan, Xi; Liu, Han; Zhao, Riyang; Fatima, Sumaya; Zhao, Lianmei; Gao, Feng

doi:10.1016/j.heliyon.2022.e09953

Cited by 20 publications

(16 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CXCL8 interacts with CXCL1 and CXCL2 to promote the secretion of multiple proinflammatory, angiogenic, and immunomodulatory factors (including MMP and VEGF) by neutrophils, thereby promoting tumor metastasis in patients with NSCLC [ 36 , 37 ]. Yan et al [ 38 ] showed that IL-8 is highly expressed in lung cancer and suggested that it could be a potential biomarker for lung cancer and has strong diagnostic properties for lung cancer. In another study, the methyltransferase SETD2 was found to inhibit tumor growth and metastasis through STAT1-IL-8 signaling-mediated epithelial-mesenchymal transition in lung adenocarcinoma [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Citrus aurantium on Non‐Small‐Cell Lung Cancer: A Research Based on Network and Experimental Pharmacology

Yao

Zhang

Huang

et al. 2023

BioMed Research International

View full text Add to dashboard Cite

Purpose. To screen the main active components of Citrus aurantium through a network pharmacology approach, construct a component-disease target network, explore its molecular mechanism for the treatment of non-small-cell lung cancer (NSCLC), and validate it experimentally. Methods. The active ingredients in Citrus aurantium and the targets of Citrus aurantium and NSCLC were collected through the Traditional Chinese Medicine Systematic Pharmacology Database and Analysis Platform (TCMSP), GeneCards, and OMIM databases. The protein interaction network was constructed using the STRING database, and the component-disease relationship network graph was analyzed using Cytoscape 3.9.1. The Metascape database can be used for GO and KEGG enrichment analyses. The Kaplan-Meier plotter was applied for overall survival analysis of key targets of Citrus aurantium in the treatment of NSCLC. Real-time PCR (RT-PCR) and Western blotting were used to determine the mRNA and protein levels of key targets of Citrus aurantium for the treatment of NSCLC. Results. Five active ingredients of Citrus aurantium were screened, and 54 potential targets for the treatment of NSCLC were found, of which the key ingredient was nobiletin and the key targets are TP53, CXCL8, ESR1, PPAR-α, and MMP9. GO and KEGG enrichment analyses indicated that the mechanism of nobiletin in treating NSCLC may be related to the regulation of cancer signaling pathway, phosphatidylinositol-3 kinase (PI3K)/protein kinase B (Akt) signaling pathway, lipid and atherosclerosis signaling pathway, and neurodegenerative signaling pathway. The experimental results showed that nobiletin could inhibit the proliferation of NSCLC cells and upregulate the levels of P53 and PPAR-α and suppress the expression of MMP9 ( P < 0.05 ). Conclusion. Citrus aurantium can participate in the treatment of NSCLC through multiple targets and pathways.

show abstract

Section: Discussionmentioning

confidence: 99%

The Effect of Citrus aurantium on Non‐Small‐Cell Lung Cancer: A Research Based on Network and Experimental Pharmacology

Yao

Zhang

Huang

et al. 2023

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Mechanistically, cancer-related inflammation is thought to be the seventh hallmark of cancer and plays a profound role in cancer initiation and development [ 38 , 39 ]; in turn, cancer cells can also promote self-development by secreting inflammatory cytokines in an autocrine manner [ 40 ]. In lung cancer, some cytokines were significantly elevated in patients, such as interleukin-6 (IL-6) [ 41 , 42 ], which has broad functions in regulating cancer cells. For example, IL-6 can promote cell proliferation [ 43 ], metastasis, and epithelial-mesenchymal transition (EMT) [ 44 ]; it can also contribute to treatment (cisplatin [ 45 ], EGF receptor (EGFR) tyrosine kinase inhibitors (TKIs) [ 46 ]) resistance.…”

Section: Discussionmentioning

confidence: 99%

“…For example, IL-6 can promote cell proliferation [ 43 ], metastasis, and epithelial-mesenchymal transition (EMT) [ 44 ]; it can also contribute to treatment (cisplatin [ 45 ], EGF receptor (EGFR) tyrosine kinase inhibitors (TKIs) [ 46 ]) resistance. Many studies have indicated that abnormally elevated IL-6 predicts poor survival in lung cancer [ 41 , 42 , 47 ]. Interestingly, systematic evaluation of IL-6 can also result in a fluctuation of RDW, as an increase or decrease in RDW was closely correlated with high or low levels of IL-6, although not in the cancer background [ 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

A combined preoperative red cell distribution width and carcinoembryonic antigen score contribute to prognosis prediction in stage I lung adenocarcinoma

Lin

et al. 2023

World J Surg Onc

View full text Add to dashboard Cite

Aims Hematological markers that can be used for prognosis prediction for stage I lung adenocarcinoma (LUAD) are still lacking. Here, we examined the prognostic value of a combination of the red cell distribution width (RDW) and carcinoembryonic antigen (CEA), namely, the RDW-CEA score (RCS), in stage I LUAD. Materials and methods A retrospective study with 154 patients with stage I LUAD was conducted. Patients were divided into RCS 1 (decreased RDW and CEA), RCS 2 (decreased RDW and increased CEA, increased RDW and decreased CEA), and RCS 3 (increased RDW and CEA) subgroups based on the best optimal cutoff points of RDW and CEA for overall survival (OS). The differences in other clinicopathological parameters among RCS subgroups were calculated. Disease-free survival (DFS) and OS among these groups were determined by Kaplan–Meier analysis, and risk factors for outcome were calculated by a Cox proportional hazards model. Results Seventy, 65, and 19 patients were assigned to the RCS 1, 2, and 3 subgroups, respectively. Patients ≥ 60 years (P < 0.001), male sex (P = 0.004), T2 stage (P = 0.004), and IB stage (P = 0.006) were more significant in the RCS 2 or 3 subgroups. The RCS had a good area under the curve (AUC) for predicting DFS (AUC = 0.81, P < 0.001) and OS (AUC = 0.93, P < 0.001). The DFS (log-rank = 33.26, P < 0.001) and OS (log-rank = 42.05, P < 0.001) were significantly different among RCS subgroups, with RCS 3 patients displaying the worst survival compared to RCS 1 or 2 patients. RCS 3 was also an independent risk factor for both DFS and OS. Conclusions RCS is a useful prognostic indicator in stage I LUAD patients, and RCS 3 patients have poorer survival. However, randomized controlled trials are needed to validate our findings in the future.

show abstract

“…For instance, a two-marker panel of IL-8 and CEA was proposed for the prognosis of lung cancer metastasis. 56 However, fabricating biosensors for IL detection is challenged by their very low concentrations in different body fluids as well as the need for simultaneous detection of multiple ILs for differential disease diagnosis. A panel of three biomarkers (IL-6, IL-8, CEA) was recently reported for diagnosis and prediction of metastasis of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Review—Electrochemical Biosensors for Interleukins: Electrode Materials

Yahia

Tawfik

Fritzsche

et al. 2023

J. Electrochem. Soc.

View full text Add to dashboard Cite

Interleukins gained great interest as potential biomarkers for autoimmune diseases, cancers, and viral infections. Challenges faced in the detection of interleukins include their minute concentrations in biological specimens, the need to generate quantitative results, and multi-analyte measurement for differential diagnosis. The properties of the material of the working electrode are crucial for signal transduction. Consequently, different working electrode materials were investigated to select the ones which generate the highest signal and ensure the reproducibility of the results and the robustness of the biosensor. In this review, the interleukin electrochemical biosensors developed since 2015 were classified according to the material of the working electrode into noble metals, ceramics, and carbon-based materials. The advantages and limitations of each working electrode material are discussed. Designs and performance criteria of interleukin electrochemical biosensors developed since 2015 are compared with reference to the type of working electrode material including those made of hybrid ones.

show abstract

Prognosis value of IL-6, IL-8, and IL-1β in serum of patients with lung cancer: A fresh look at interleukins as a biomarker

Cited by 20 publications

References 36 publications

The Effect of Citrus aurantium on Non‐Small‐Cell Lung Cancer: A Research Based on Network and Experimental Pharmacology

The Effect of Citrus aurantium on Non‐Small‐Cell Lung Cancer: A Research Based on Network and Experimental Pharmacology

A combined preoperative red cell distribution width and carcinoembryonic antigen score contribute to prognosis prediction in stage I lung adenocarcinoma

Review—Electrochemical Biosensors for Interleukins: Electrode Materials

Contact Info

Product

Resources

About