Prognosis Prediction for Postoperative Esophageal Cancer Patients Using Onodera's Prognostic Nutritional Index

Matsumoto, Hideo; Okamoto, Yuko; Kawai, Akimitsu; Ueno, Daisuke; Kubota, Hisako; Murakami, Haruaki; Higashida, Masaharu; Hirai, Toshihiro

doi:10.1080/01635581.2017.1339093

Cited by 32 publications

(31 citation statements)

References 36 publications

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“…OPNI is an indicator related to nutritional and immune status (24). Hideo Matsumoto et al showed that OPNI may be a useful indicator of postoperative complications and length of hospital stay in patients with pancreatic cancer, and may affect overall survival 6 months after surgery (25). In the analysis of OPNI in patients with colorectal cancer and malignant pleural mesothelioma, some scholars found that the prognosis of patients with OPNI lower than cut-off value was signi cantly worse than that of patients with OPNI higher than cut-off value (26)(27).…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of inflammatory and nutritional markers for hepatocellular carcinoma

Yuan

Zhang³

et al. 2021

Medicine

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Background: It is well known that the prognosis of cancer patients after tumor resection is closely related to the patient's autoimmune ability and nutritional status. A large number of studies have shown that the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and Onodera's prognostic nutritional index (OPNI) are signi cantly correlated with the prognosis of various tumors. In this study, we analyzed the prognostic value of NLR, PLR and OPNI for hepatocellular carcinoma (HCC) for the rst time.Patients and Methods: Data of hepatocellular carcinoma patients undergoing hepatectomy in Changzhi People's Hospital (Changzhi, China) from 2011 to 2017 were retrospectively analyzed. A total of 286 patients with hepatocellular carcinoma were included in the analysis. The Optimum cut-off values of OPNI, NLR and PLR were determined by using the X-tile program. The overall survival (OS) was analyzed by Kaplan-Meier method and veri ed by log-rank test. Multivariate analysis was performed using Cox Proportional Hazard Regression model to determine independent prognostic indicators for HCC.Results: Univariate and multivariate analysis showed that OPNI (p<0.001), Treatment (Surgery, p=0.04;Interventional therapy, p=0.002), Postoperative treatment (YES, p=0.004) and Stage can be used as independent prognostic maker for HCC. Comparing the P values and hazard ratios, we found out that the OPNI has greatest in uence on prognosis in these preoperative indexes. The optimal cut-off values of NLR, PLR and OPNI were 2.5, 133.3 and 39.5, respectively. Compared with the low OPNI group, the high OPNI group had a better prognosis. In the correlation analysis between OPNI and clinicopathological features, only Age and NLR showed statistical differences, while others did not.Conclusions: OPNI can be used as a simple and effective independent prognostic marker for hepatocellular carcinoma.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of inflammatory and nutritional markers for hepatocellular carcinoma

Yuan

Zhang³

et al. 2021

Medicine

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“…We excluded such patients in the present study to avoid biasing prognostic factors by inserting these factors in multivariate analysis. We found 7 articles on preoperative PNI and prognosis after EC surgery in patients who did not receive neoadjuvant treatment [28][29][30][31][32][33][34]. The findings of these studies are controversial; only 2 of 7 studies showed a favorable survival in the high preoperative PNI group, while the other studies arrived at conflicting results.…”

Section: Discussionmentioning

confidence: 99%

Perioperative Predictive Markers for Recurrence of Esophageal Cancer after Esophagectomy

Fujiwara

Higashida

Kubota

et al. 2021

Gastrointest Tumors

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Introduction: We studied whether perioperative nutritional, immunological factors or postoperative inflammatory responses predicted esophageal cancer (EC) progression and prognosis in patients who received esophagectomies. Methods: We evaluated preoperative prognostic nutritional index (PNI), BMI, neutrophil-to-lymphocyte ratio (NLR), intraoperative blood loss, postoperative C-reactive protein (CRP) max, recurrence-free survival (RFS), and overall survival (OS) in 111 patients with pStage I–IV squamous cell EC who received esophagectomies. Optimal cutoff values for each continuous parameter were determined by receiver operating characteristic curves and Youden indices. Univariate and multivariate Cox analyses were used to derive independent prognostic factors. Propensity score matching using inverse probability of treatment weighting was used in groups divided by Youden indices, as appropriate. Results: Cutoff values of continuous variables were NLR: 2.27, PNI: 44.2, blood loss: 159 mL, and CRPmax: 21.7 mg/dL. In multivariate analyses, PNI, CRPmax, and intraoperative blood loss were independent prognostic factors for OS and RFS. Among patients with stage II–IV disease, low PNI was associated with shorter RFS. Postoperative respiratory complications were associated with both higher CRP and shorter RFS. Discussion/Conclusions: Low preoperative PNI and high postoperative inflammatory response were associated with postoperative EC progression after esophagectomy. Preoperative nutritional interventions or suppression of postoperative inflammatory response, including respiratory complications, may improve patient prognosis.

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“…Ce pronostic est meilleur en Europe et en Asie à cause d'une part du niveau socio-économique et d'autre part du dépistage systématique. Plusieurs facteurs pouvant modifier la survie ont été retrouvés, à savoir l'âge des patients, le sexe, la race, le niveau socio-économique bas, la nutrition, la prise en charge des complications liées à la maladie [2, 3, 7, 18, 19]. Le facteur qui semble être commun à toutes ses études mais aussi à la nôtre est le stade tumoral, car il détermine le type de traitement.…”

Section: Discussionunclassified

Facteurs pronostiques du cancer de l'œsophage au Cameroun: étude multicentrique

Nga¹,

Eloumou²,

Engbang³

et al. 2019

Pan Afr Med J

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Introduction Le cancer de l'œsophage est une affection rare. Le pronostic péjoratif est lié au diagnostic tardif. La survie à 5 ans est de moins de 20%. Le but de ce travail était de rechercher les facteurs associés à la survie des patients atteints d'un cancer de l'œsophage au Cameroun. Méthodes Il s'agissait d'une étude pronostique, sur une période de 11 ans allant du 1 er janvier 2005 au 31 décembre 2015 dans les Hôpitaux Généraux de Yaoundé et de Douala. Les paramètres étudiés étaient ceux associés à la survie. La survie était établie en fonction de la date du diagnostic et de la date du décès ou de la dernière consultation. Le logiciel SPSS (Statistical Package for Social Sciences) version 23 a permis l'analyse des données. La survie était présentée sous forme de courbe de Kaplan Meier. Le Test de Log Rank a permis la comparaison entre les différents groupes. La régression de Cox a permis de ressortir les différents facteurs associés. Le seuil de significativité était de 0,05. Résultats Nous avons colligé 49 dossiers. L'âge moyen était de 57,83 ans. Le sexe masculin était présent dans 71,4% (n = 35) des cas pour un sex ratio à 2,49. Le suivi moyen était de 3,2 mois. La médiane de survie était de 6,67 mois (IC95% [1,33-10,4]) et la moyenne de survie était de 7,99 mois (IC95% [4,42-11,17]). En analyse multivariée après ajustement il ressortait que le stade IV était un facteur prédictif de mortalité (HR = 2,79; IC95% [1,13-6,89], p = 0,025]). Conclusion Le cancer de l'œsophage reste une affection rare au pronostic péjoratif. Le facteur pronostique est le stade tumoral.

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Prognosis Prediction for Postoperative Esophageal Cancer Patients Using Onodera's Prognostic Nutritional Index

Cited by 32 publications

References 36 publications

Prognostic value of inflammatory and nutritional markers for hepatocellular carcinoma

Prognostic value of inflammatory and nutritional markers for hepatocellular carcinoma

Perioperative Predictive Markers for Recurrence of Esophageal Cancer after Esophagectomy

Facteurs pronostiques du cancer de l'œsophage au Cameroun: étude multicentrique

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