Prognosis of undifferentiated carcinoma and lymphoma of the thyroid

Rossi, Ricardo L.; Cady, Blake; Meissner, William A.; Sedgwick, Cornelius E.; Werber, Joan

doi:10.1016/0002-9610(78)90042-9

Cited by 47 publications

(14 citation statements)

References 19 publications

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“…Both malignancies were associated with a foudroyant development of obstructive symptoms as well as surgical incurability and, consecutively, a very poor prognosis. After a palliative debulking procedure, 6 of 7 patients with lymphoid neoplasms underwent an external radio-therapy, but none of them had a chemotherapy which, today, is considered to be obligatory in malignant lymphomas [5,6,8,16]. So, it cannot be excluded that this might be a reason for the lack of difference in survival between anaplastic and lymphoid tumors in our series.…”

Section: Discussionmentioning

confidence: 86%

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Immunohistochemical reclassification of anaplastic carcinoma reveals small and giant cell lymphoma

et al. 1990

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Thirty-one cases of thyroid malignancies which were originally classified as anaplastic carcinoma were reexamined immunohistochemically using PAP methods (peroxidase:antiperoxidase) for IgM, IgG, IgA, cytokeratin, calcitonin, lysozyme and alpha-1-antitrypsin. The reclassification results were compared with patient data such as clinical symptoms, treatment modalities, and clinical outcome. Postoperative radiotherapy was carried out in more than 80% of cases, chemotherapy in none. Seven of 31 tumors showed a positive staining for IgM (n = 4), IgG (n = 2), and IgA (n = 1) antibodies. All of these cases were negative for epithelial markers. Surprisingly, not only all small cell tumors (n = 3) but also 4 tissues with predominantly giant cell areas were among those reclassified as primary malignant lymphoma.

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Section: Discussionmentioning

confidence: 86%

“…Despite the progress of treatment modalities (radiotherapy, chemotherapy) in recent years, the prognosis of patients suffering from anaplastic carcinoma of the thyroid remains poor [3,5,6]. Where there are any 5-year survivors at all, some authors question the correctness of the original diagnosis [3,5].…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical reclassification of anaplastic carcinoma reveals small and giant cell lymphoma

et al. 1990

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“…Devine et al found that combining surgical resection with radiotherapy to treat lymphoma offered no significant survival advantage [24]. In contrast, Rossl et al advocated total tumor excision, whenever possible, as well as postoperative radiation [25].…”

Section: Managementmentioning

confidence: 99%

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2013

J Surg

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Primary thyroid lymphoma is an uncommon malignancy that constitutes fewer than 2% of all extranodal non-Hodgkin lymphomas (NHLs) and only 0.6% to 5% of all thyroid malignancies. Histologic subtypes include diffuse large B-cell lymphoma, mucosa-associated lymphoid tissue lymphomas, follicular lymphomas, and rarely Hodgkin lymphomas. The rarity of this disease precludes optimizing diagnostic and management modalities. This review provides an evaluation of the presentation of thyroid lymphoma and the current diagnosis, evaluation, and management of thyroid lymphoma.

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“…Obstruction can occur secondary to bilateral vocal cord palsy, extrinsic compression of the trachea or larynx, or intraluminal tumour invasion 2,3 . This occurs more frequently in the more aggressive thyroid cancer subtypes such as poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) 4 In the case of ATC, airway obstruction is the cause of death in up to 60% of patients, 5 with a median survival of 3–7 months 4,6,7 …”

Section: Introductionmentioning

confidence: 99%

“…such as poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) 4 In the case of ATC, airway obstruction is the cause of death in up to 60% of patients, 5 with a median survival of 3-7 months. 4,6,7 The management of airway obstruction arising from locally advanced thyroid cancer infiltration can be challenging.…”

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confidence: 99%

A systematic review of endotracheal stenting in patients with locally advanced thyroid cancer

Schuster-Bruce

Sargent

Madden

et al. 2022

Clinical Otolaryngology

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Local invasion by thyroid cancer into adjacent anatomical structures, namely the trachea and recurrent laryngeal nerves, can obstruct the airway with an attendant risk of death. 1 Obstruction can occur secondary to bilateral vocal cord palsy, extrinsic compression of the trachea or larynx, or intraluminal tumour invasion. 2,3 This occurs more frequently in the more aggressive thyroid cancer subtypes

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Prognosis of undifferentiated carcinoma and lymphoma of the thyroid

Cited by 47 publications

References 19 publications

Immunohistochemical reclassification of anaplastic carcinoma reveals small and giant cell lymphoma

Immunohistochemical reclassification of anaplastic carcinoma reveals small and giant cell lymphoma

Untitled

A systematic review of endotracheal stenting in patients with locally advanced thyroid cancer

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