Prognosis of sudden deafness with special reference to risk factors of microvascular pathology

Hirano, Kōji; Ikeda, Katsuhisa; Kawase, Tetsuaki; Oshima, Takeshi; Kekehata, Seiji; Takahashi, Shin; Sato, Toshiharu; Kobayashi, Toshimitsu; Takasaka, Tomonori

doi:10.1016/s0385-8146(98)00072-8

Cited by 57 publications

(51 citation statements)

References 13 publications

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“…We found no association between the audiogram shape and the final hearing threshold, whereas the audiogram type appeared as an important prognostic factor in several studies based on the recovery rate [Byl, 1984;Chang et al, 2005;Tran Ba Huy and Sauvaget, 2005;Ceylan et al, 2007]. Presence of cardiovascular risk factors, suggesting microvascular disorders, did not influence the final hearing threshold in our study, or the recovery rate in the literature [Ulrich et al, 1992;Hirano et al, 1999;Ceylan et al, 2007]. Presence of vertigo and dizziness and time elapsed from the onset of ISSHL are negatively correlated with the recovery rate in several studies [Byl, 1984;Chang et al, 2005;Ceylan et al, 2007].…”

Section: Audiometric Patterns and Predictive Factors Of Final Hearingcontrasting

confidence: 67%

Cardiovascular and Thromboembolic Risk Factors in Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study

Mosnier

Stépanian²,

Baron³

et al. 2010

Audiol Neurotol

138

126

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Objective: The pathogenesis of idiopathic sudden sensorineural hearing loss (ISSHL) remains unknown, but vascular involvement is one of the main hypotheses. The main objective of this study was to investigate the association between ISSHL and cardiovascular and thromboembolic risk factors. Study Design: Multicentric case-control study. Methods: Ninety-six Caucasian patients with ISSHL and 179 sex- and age-matched controls were included. Patients were evaluated on the day of the inclusion and 1 week, 3 weeks and 3 months later. Clinical information concerning personal and familial cardiovascular and thromboembolic risk factors and concerning the ISSHL was collected. Blood samples were collected for genetic analysis of factor V Leiden and G20210A polymorphism in the factor II gene. The severity of the hearing loss was classified as mild (21–40 dB), moderate (41–70 dB), severe (71–90 dB) and profound or total (>90 dB). Hearing improvement was calculated as a relative improvement of hearing thresholds using the contralateral ear as baseline. Results: Systolic blood pressure was higher in patients (130 ± 1.7 mm Hg) than in controls (124 ± 1.1 mm Hg, p = 0.003). The personal/familial history of cardiovascular events was also more prevalent in patients (p = 0.023 and p = 0.014, respectively), whereas no difference was found in the prevalence of personal cardiovascular risk factors (hypertension, diabetes mellitus, hyperlipidemia, smoking habits). There was no correlation between the audiogram type, the hearing outcome and the presence of cardiovascular risk factors. No significant difference was observed in the personal/familial history or in the presence of thromboembolic risk factors. The prothrombin and factor V mutations were uncommon in both patients and controls. The final hearing threshold was only correlated with the severity of the initial hearing loss (p < 0.001), but not influenced by the presence of vertigo, audiogram type, time elapsed from onset of ISSHL to hospitalization or failure of a previous oral therapy. Hearing stabilization was obtained at 21 days in 92% of patients. Conclusion: These results support the theory of vascular involvement as the etiology of some cases of ISSHL. The sole predictive factor of poor final hearing is the severity of the initial hearing loss.

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Section: Audiometric Patterns and Predictive Factors Of Final Hearingcontrasting

confidence: 67%

Cardiovascular and Thromboembolic Risk Factors in Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study

Mosnier

Stépanian²,

Baron³

et al. 2010

Audiol Neurotol

138

126

View full text Add to dashboard Cite

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“…Furthermore, high blood cholesterol levels are known to be an important risk factor for endothelial dysfunction and vascular thrombosis. 18 The significantly higher levels of serum homocysteine and cholesterol, and the lower levels of Although the homocysteine and folate levels in our patients and controls were statistically different, they were both within the normal range (at the upper and lower limit, respectively). We suppose that although not sufficient to cause major cardiovascular disease slight modifications in these substances may favor microvascular impairment, especially in such terminal vascular systems as the cochlear.…”

Section: Discussioncontrasting

confidence: 45%

Sudden hearing loss and MTHFR 677C>T/1298A>C gene polymorphisms

Capaccio

Ottaviani

Cuccarini

et al. 2005

Genetics in Medicine

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“…Although data on the association between elevated cholesterol and incident hearing loss are scant, a case-control study with 4071 cases of hearing loss demonstrated a significant association between hyperlipidemia and noise-induced hearing loss 23 . Moreover, studies have suggested that disturbances to microcirculation caused by hyperlipidemia may lead to inner ear disease 24,25 .…”

Section: Discussionmentioning

confidence: 99%

A Prospective Study of Cardiovascular Risk Factors and Incident Hearing Loss in Men

et al. 2010

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Objective-Hearing loss is the most common sensory disorder in the US, afflicting over 36 million people. Cardiovascular risk factors have been associated with hearing loss risk in crosssectional studies, but prospective data are currently lacking.Methods-We prospectively evaluated the association between diagnosis of hypertension, diabetes mellitus, hypercholesterolemia, smoking and body mass index (BMI) and incidence of hearing loss. Participants were 26,917 men in the Health Professionals Follow-up Study, aged 40-74 years at baseline in 1986. Study participants completed questionnaires about lifestyle and medical history every two years.Information on self-reported professionally diagnosed hearing loss and year of diagnosis was obtained from the 2004 questionnaire, and cases were defined as hearing loss diagnosed between 1986 and 2004. Multivariable-adjusted hazard ratios (HRs) were calculated using Cox proportional hazards regression models.Results-3,488 cases of hearing loss were identified. History of hypertension (HR 0.96, 95% CI 0.88-1.03), diabetes mellitus (HR 0.92, 95% CI 0.78-1.08), or obesity (HR 1.02, 95% CI 0.90-1.15 for BMI≥30 compared to normal range of 19-24.9) was not significantly associated with hearing loss risk, while hypercholesterolemia (HR 1.10, 95% CI 1.02-1.18) and past smoking history (HR 1.09, 95% CI 1.01-1.17) were associated with a significantly increased risk of hearing loss after multivariate adjustment.Conclusion-A history of hypertension, diabetes mellitus, or obesity is not associated with increased risk of hearing loss, while a history of past smoking or hypercholesterolemia has a small but statistically significant association with increased risk of hearing loss in adult males.

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Prognosis of sudden deafness with special reference to risk factors of microvascular pathology

Cited by 57 publications

References 13 publications

Cardiovascular and Thromboembolic Risk Factors in Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study

Cardiovascular and Thromboembolic Risk Factors in Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study

Sudden hearing loss and MTHFR 677C>T/1298A>C gene polymorphisms

A Prospective Study of Cardiovascular Risk Factors and Incident Hearing Loss in Men

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