Prognosis of segmentectomy in the treatment of stage IA non‑small cell lung cancer (Review)

Bai, Wenliang; Li, Shanqing

doi:10.3892/ol.2020.12335

Cited by 6 publications

(3 citation statements)

References 50 publications

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“…The concerns associated with the use of segmentectomy for inner lesions are the difficulty in securing the proximal margin and the high dominance of lymph node metastasis. Regarding the proximal margin, although there are no accepted criteria to prevent loco-regional relapse, margins of 15 mm for a deflated lung and 20 mm for an inflated lung would be acceptable according to the previous literature [ 7 , 8 ]. In our institution, segmentectomy has been allowed in cases where a 20-mm distance can be secured from the hilum on preoperative evaluation.…”

Section: Discussionmentioning

confidence: 99%

Segmentectomy versus lobectomy for inner-located small-sized early non-small-cell lung cancer

Tane

Kitamura

Kimura

et al. 2022

Interactive CardioVascular and Thoracic Surgery

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Objectives Although segmentectomy is an acceptable alternative to lobectomy for peripheral small-sized non-small-cell lung cancer, the effectiveness of segmentectomy for inner lesions remains unknown. The aim of this study was to examine the feasibility of segmentectomy in comparison with lobectomy for inner lesions. Methods We retrospectively analyzed 570 patients with small (≤2 cm) cN0 non-small-cell lung cancer who underwent segmentectomy or lobectomy between January 2007 and March 2021. We focused on patients with lesions located in the inner two-thirds, which was determined using three-dimensional computed tomography (n = 227). After propensity-score matching analysis based on sex, age, pulmonary function, serum carcinoembryonic antigen level, radiographic tumor findings, and tumor location, we compared the surgical and oncological outcomes in patients who underwent segmentectomy (n = 66) and lobectomy (n = 66). Results Postoperative mortality or morbidity did not differ significantly between the two groups. The 5-year recurrence-free and overall survival rates in the segmentectomy and lobectomy groups were 93.6% vs. 84.1% and 95.8% vs. 87.9%, respectively. The differences between two groups were not significant (p = 0.62 and p = 0.23, respectively). The two groups also showed no differences in locoregional recurrence. Multivariable Cox regression analysis revealed that segmentectomy had a comparable impact on recurrence-free survival (hazard ratio, 0.61; 95% confidence interval, 0.17-2.03; p = 0.43). Conclusion Segmentectomy for inner-located small-sized non-small-cell lung tumors could be an acceptable treatment in comparison with lobectomy.

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Section: Discussionmentioning

confidence: 99%

Segmentectomy versus lobectomy for inner-located small-sized early non-small-cell lung cancer

Tane

Kitamura

Kimura

et al. 2022

Interactive CardioVascular and Thoracic Surgery

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“… 11 Experts noted that a key goal when planning the extent of segmentectomy is ensuring sufficient surgical margin can be achieved as insufficient surgical margins may be associated with the risk of locoregional recurrence. 12 …”

Section: Discussionmentioning

confidence: 99%

Asia expert consensus on segmentectomy in non–small cell lung cancer: A modified Delphi study

Liu¹,

Aokage²,

Chen³

et al. 2023

JTCVS Open

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“…Currently, the widely used clinical treatments for NSCLC mainly include surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy; however, the specific treatment depends on the stage of the disease and the patient’s health status. Few patients with early stage NSCLC require surgical treatment, and the 5-year survival rate of patients with stage IA NSCLC is 70% [ 3 ]. However, for patients with advanced NSCLC, surgery combined with chemotherapy or radiation therapy is necessary, and the overall 5-year survival rate is only 14–17%, with a poor prognosis [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Roles of hypoxic environment and M2 macrophage-derived extracellular vesicles on the progression of non-small cell lung cancer

Chu

Wang

et al. 2023

BMC Pulm Med

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Background Hypoxia contributes to the development of invasive and metastatic cancer cells, and is detrimental to cancer treatment. This study aimed to explore the molecular mechanisms by which hypoxic microenvironments affect hypoxic non-small cell lung cancer (NSCLC) development and the effects of M2 macrophage-derived extracellular vesicles (EVs) on NSCLC cells. Methods A549 cells were cultured in an anoxic incubator for 48 h to construct hypoxic A549 cells, and then normal and hypoxic A549 cells were harvested for RNA sequencing. Next, THP-1 cells were used to induce M2 macrophages, and EVs were isolated from THP-1 cells and M2 macrophages. Cell counting kit-8 and transwell assays were used to determine the viability and migration of hypoxic A549 cells, respectively. Results After sequencing, 2426 DElncRNAs and 501 DEmiRNAs were identified in normal A549 cells and hypoxic A549 cells. These DElncRNAs and DEmiRNAs were significantly enriched in “Wnt signaling pathway,” “Hippo signaling pathway,” “Rap1 signaling pathway,” “calcium signaling pathway,” “mTOR signaling pathway,” and “TNF signaling pathway.” Subsequently, ceRNA networks consisting of 4 lncRNA NDRG1 transcripts, 16 miRNAs and 221 target mRNAs were built, and the genes in the ceRNA networks were significantly associated with “Hippo signaling pathway” and “HIF-1 signaling pathway.” EVs were successfully extracted from THP-1 cells and M2 macrophages, and M2 macrophage-derived EVs significantly enhanced the viability and migration of hypoxic A549 cells. Finally, M2 macrophage-derived EVs further upregulated the expression of NDRG1-009, NDRG1-006, VEGFA, and EGLN3, while downregulating miR-34c-5p, miR-346, and miR-205-5p in hypoxic A549 cells. Conclusions M2 macrophage-derived EVs may worsen the progression of NSCLC in a hypoxic microenvironment by regulating the NDRG1-009-miR-34c-5p-VEGFA, NDRG1-006-miR-346-EGLN3, NDRG1-009-miR-205-5p-VEGFA, and Hippo/HIF-1 signaling pathways.

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Prognosis of segmentectomy in the treatment of stage IA non‑small cell lung cancer (Review)

Cited by 6 publications

References 50 publications

Segmentectomy versus lobectomy for inner-located small-sized early non-small-cell lung cancer

Segmentectomy versus lobectomy for inner-located small-sized early non-small-cell lung cancer

Asia expert consensus on segmentectomy in non–small cell lung cancer: A modified Delphi study

Roles of hypoxic environment and M2 macrophage-derived extracellular vesicles on the progression of non-small cell lung cancer

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