Prognosis of Pulmonary Arterial Hypertension*

McLaughlin, Vallerie V.; Presberg, Kenneth W.; Doyle, Ramona L.; Abman, Steven H.; McCrory, Douglas C; Fortin, Terry; Ahearn, Gregory S.

doi:10.1378/chest.126.1_suppl.78s

Cited by 457 publications

(78 citation statements)

References 43 publications

(65 reference statements)

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“…Previous studies had mentioned that many patients with CTEPH haven't had a documented DVT [24] [25]. Patients monitored for pulmonary hypertension of another cause may exhibit symptoms similar to those of CTEPH [26] this was similar to the findings of our study. Tachycardia and Syncope were also present with least frequencies.…”

Section: Resultssupporting

confidence: 90%

Findings Associated with Pulmonary Hypertension: CT Angiography Based Study

Aloub¹,

Ayad²,

Elnabi³

2016

OJRad

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Pulmonary hypertension (PH) is a complex disorder and may be related to a variety of diseases. It may arise in association with chronic thromboembolic pulmonary hypertension (CTEPH) or pulmonary embolism (PE). Knowledge of the radiological features is required to characterize and accurately diagnose the conditions and may improve the outcome. This study was designed to evaluate the clinical characteristics and the computerized tomography angiography findings in patients with PH, PE and CTEPH. Contrast-enhanced CT scans were acquired in 55 Sudanese patients with PE, 20 patients with PH, 25 patients with CTEPH and 50 normal subjects who were considered as control group. The CT diagnostic criteria for all cases were characterized. The clinical signs, parenchymal abnormalities, pulmonary tree and cardiac segments in all groups were characterized and compared with the control group. The results showed that the most common clinical characteristics were found to be chest pain, dyspnea, lower limb swelling, tachycardia and syncope which were correlated significantly with the presence of the disease. In all patients groups, the pulmonary vascular segments, cardiac segments and lung parenchyma changes were detected and were significantly different from the normal control subjects at p ≤ 0.01. It was found that CT angiography has a significant role in the diagnostic evaluation of these groups of patients. CT imaging is acceptably used in diagnosis, defining cause, quantifying heart segments and parenchyma changes in order to assess the feasibility of surgery, monitoring and therapeutic planning.

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Section: Resultssupporting

confidence: 90%

Findings Associated with Pulmonary Hypertension: CT Angiography Based Study

Aloub¹,

Ayad²,

Elnabi³

2016

OJRad

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“…While patients with idiopathic PAH respond best to prostaglandin analogue treatment, patients with PAH due to CTD have a worse prognosis (1,3,17). The improvement in prognosis is well documented in patient with idiopathic PAH on treatment with iv PGI 2 (1,5,15,20). For inh ilo, a benefit concerning event free follow up is currently published over a period of 3 months (13).…”

Section: Discussionmentioning

confidence: 99%

“…None of the patient had an acute significant vasodilator response to inhaled nitric oxide according to current guidelines (1,15). All patients were in WHO stage III-IV with indication for specific pulmonary vasoactive therapy (1).…”

Section: Initial Assessmentmentioning

confidence: 99%

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Intravenous epoprostenol versus high dose inhaled iloprost for long-term treatment of pulmonary hypertension

Reichenberger¹,

A²,

Morrell³

et al. 2011

Pulmonary Pharmacology & Therapeutics

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Background: Intravenous prostacyclin (iv PGI) and inhaled Iloprost (inh ilo) are established therapies in pulmonary arterial hypertension (PAH), however comparative data are lacking.Methods and Patients: We performed a long-term open label comparison trial of iv PGI or high dose inh ilo in 24 patients with severe PAH: 12 patients (9 female, 40 +/-14 years, 10 idiopathic PAH, 2 PAH in connective tissue disease CTD) received iv PGI, whereas 12 patients (7 female, 43 +/-12 years, 5 IPAH, 6 CTD, 1 porto-pulmonary hypertension) were commenced on inh ilo with a median dose of 120 µg / 24 hours. Hemodynamic parameters and 6 minute walking distance (6MWD) at baseline did not differ between both groups.Results: After 3 months therapy, patients on iv PGI showed a significant increase in 6 MWD from 220 to 280 meters (p<0.01), whereas patients on high dose inh ilo

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“…Los pacientes con Síndrome de Eisenmenger tienen mejor pronóstico que los que presentan los otros tipos de hipertensión arterial pulmonar en la clasificación de Danna Point grupo 1 (8,9,10). La existencia de un defecto con capacidad para descargar las cavidades derechas permite que la clínica de congestión venosa aparezca tardíamente, a la vez que se mantenga el gasto cardíaco sistémico hasta fases avanzadas; todo ello a expensas de un cortocircuito derecha-izquierda y, por tanto, de hipoxemia arterial y cianosis (4,9,10).…”

Section: Introductionunclassified

Hipertensión arterial pulmonar (síndrome de Eisenmenger) en el embarazo. Presentación de caso

Cortés¹,

Vásquez²,

Méndez³

et al. 2015

Rev. Sal. Bosq

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ResumenEl síndrome o complejo Eisenmenger (hipertensión arterial pulmonar asociada a cardiopatía congénita) es una entidad poco frecuente en la población y en la mujer gestante, describiéndose una alta mortalidad materno fetal (20 al 40%) y complicaciones obstétricas relacionadas con la entidad: amenaza de parto pretérmino, restricción del crecimiento fetal, insuficiencia placentaria, entre otras.Este artículo describe el caso de una mujer en segundo trimestre de embarazo con síndrome de Eisenmenger, diagnosticada y manejada en un hospital de cuarto nivel colombiano, con el fin de revisar la literatura al respecto, pero, de especial interés, con el fin de compartir la experiencia en el manejo médico de esta situación tan AbstractEisenmenger complex (pulmonary arterial hypertension associated with congenital heart disease) is a rare entity in the individual population and in pregnant women, describing a high maternal and fetal mortality (20 to 40%) and it's well known obstetric complications related entity: preterm delivery, intrauterine growth restriction, placental insufficiency, etc.We describe the case of a pregnant woman in the second trimester with Eisenmenger´s syndrome who was monitored, diagnosed and managed by high complex hospital, in order to review scientific literature and illustrate the experience of medical management of Eisenmenger´s Syndrome during the pregnancy.

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Prognosis of Pulmonary Arterial Hypertension*

Cited by 457 publications

References 43 publications

Findings Associated with Pulmonary Hypertension: CT Angiography Based Study

Findings Associated with Pulmonary Hypertension: CT Angiography Based Study

Intravenous epoprostenol versus high dose inhaled iloprost for long-term treatment of pulmonary hypertension

Hipertensión arterial pulmonar (síndrome de Eisenmenger) en el embarazo. Presentación de caso

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