Prognosis of patients with poorly differentiated gastric neuroendocrine neoplasms: a multi-center study in China

Abstract

Background: The incidence of poorly differentiated gastric neuroendocrine neoplasms (G-NENs) has been increasing during the past decades. Methods: A total of 183 patients diagnosed with poorly differentiated G-NENs were enrolled from eight hospitals during 2010–2019 in China. All cases included have accepted abdominal surgery in tertiary hospitals. Result: T3 (HR: 2.66, p = 0.019), T4 (HR: 3.62, p = 0.005), stage IV (HR: 5.67, p < 0.001), vascular invasion (HR: 1.59, p = 0.048) were independent risk factors for poor prognosis of poorly differentiated G-NENs. In stratified analysis, for patients with stage III tumors, those treated with chemotherapy had significantly longer survival than those accepting surgery alone. Conclusion: T3/T4 stage, TNM stage IV and vascular invasion were independent negative prognostic factors for patients with poorly differentiated G-NENs. Patients with stage III tumors can benefit from chemotherapy. Highly selected patients with stage IV tumors may also benefit from surgery.

Clinicopathological characteristics of gastric neuroendocrine neoplasms: A comprehensive analysis

“…31,55,56 Drawing from a comprehensive and thorough comprehension of g-NEC and g-MiNEN, most researchers agree that postoperative adjuvant chemotherapy could offer potential benefits to these patients. 27,[57][58][59][60] However, it is important to note that certain studies have reported the ineffectiveness of adjuvant chemotherapy in treating g-NEC and g-MiNEN, failing to demonstrate significant enhancements in survival outcomes. 61,62 The variations in treatment outcomes can be attributed to several factors, including tumor heterogeneity, drug selection, and population responsiveness.…”

“…Recent years have witnessed surgical resection establishing itself as the most effective therapeutic approach for g‐NEC 31,55,56 . Drawing from a comprehensive and thorough comprehension of g‐NEC and g‐MiNEN, most researchers agree that postoperative adjuvant chemotherapy could offer potential benefits to these patients 27,57–60 . However, it is important to note that certain studies have reported the ineffectiveness of adjuvant chemotherapy in treating g‐NEC and g‐MiNEN, failing to demonstrate significant enhancements in survival outcomes 61,62 .…”