Prognosis of patients with intrahepatic recurrence after hepatic resection for hepatocellular carcinoma: A retrospective study

Deregulation of HIF1-alpha and hypoxia-regulated pathways in hepatocellular carcinoma and corresponding non-malignant liver tissue—influence of a modulated host stroma on the prognosis of HCC

“…The identification of patients at risk of recurrence or poor prognosis would allow us to personalize multimodal therapy strategies. Among the various clinical and histo-pathological factors found to predict survival and tumor recurrence tumor size, multifocal tumors, high alpha-fetoprotein (AFP) levels, poorly differentiated tumors, and vascular invasion have been reported [4][5][6]. In addition, an array of genetic alterations like mutations of the tumor suppressor gene TP53 or over-expression of growth factors, cyclin D1 and oncogenes like c-myc have been linked to hepatocarcinogenesis.…”

1H-NMR-based metabolomics of tumor tissue for the metabolic characterization of rat hepatocellular carcinoma formation and metastasis

“…Its 5-year survival rate after surgery is only~5-6%, primarily due to high recurrence and metastasis rates [2,3]. Prevention of both recurrence and distant metastasis is a goal that could improve the efficacy of current treatment modalities, significantly improve the patients' quality of life, and enhance survival rates.…”

Nucleotide Analogs for Patients with HBV-Related Hepatocellular Carcinoma Increase the Survival Rate through Improved Liver Function

“…HCC is characterized by a high incidence of intrahepatic recurrence, including intrahepatic metastasis and multicentric occurrence, even after curative treatment (6)(7)(8)(9); therefore, most patients with recurrent HCC need to be treated repeatedly. Although hepatic resection and radiofrequency ablation (RFA) are recognized as curative treatments, many cirrhotic patients cannot repeatedly undergo curative treatments due to the deterioration of liver function after treatment.…”