Prognosis of patients with colonic carcinoma before, during and after implementation of complete mesocolic excision

Abstract

With CME, the quality indicators of process and outcome quality improved, especially in stage III colonic carcinoma. Adjuvant chemotherapy in stage III and multidisciplinary approaches in patients with metachronous distant metastases contributed to further outcome improvement.

Safety, quality and effect of complete mesocolic excision vs non‐complete mesocolic excision in patients with colon cancer: a systemic review and meta‐analysis

“…The Hohenberger et al . study updated its data in 2016, and we selected the updated study . Finally, 12 studies with 8586 patients (3610 in the CME group and 4976 in the NCME group) were included in our study (Fig.…”

“…Five studies described safety outcomes (Table ). CME was associated with more intra‐operative blood loss (WMD 79.87, 95% CI: 65.88–93.86) and postoperative surgical complications (RR 1.23, 95% CI: 1.08–1.40) than NCME.…”

“…Nine studies included quality outcomes (Table ). CME was associated with a longer colonic resection (WMD 47.06, 95% CI: 10.49–83.62), greater distance from the tumour to the high vascular tie (WMD 17.51, 95% CI: 15.16–19.87), larger area of mesentery (WMD 36.09, 95% CI: 18.06–54.13) and more lymph nodes (WMD 6.13, 95% CI: 1.97–10.28) (Fig.…”

“…Because papers reporting long‐term survival were scarce, we assigned OS, DFS and DSS to the same index, indicated in our study as survival. Six studies described effect outcomes (Table ). CME had positive effects on 5‐year survival (HR 0.33, 95% CI: 0.13–0.81), 3‐year survival (HR 0.58, 95% CI: 0.39–0.86) and 3‐year survival for Stage III disease (HR 0.69, 95% CI: 0.60–0.80) compared with NCME (Fig.…”

Tailored Treatment of Colorectal Cancer: Surgical, Molecular, and Genetic Considerations

“…In 2008, Hohenberger et al 59 published a paper arguing for an increased focus on standardized surgical techniques for colon cancer. In a recent paper by Merkel et al, 60 they showed that 5-year cancer-related survival rate increased from 61% to 80%. This survival improvement corresponds with the nationwide implementation of CME.…”