Prognosis of myocardial infarction and brain functional asymmetry

Nikolaeva, Elena; Отева, Э. А.; Николаева, А А; Shterental, I Sh

doi:10.1016/0167-5273(93)90055-l

Cited by 5 publications

(5 citation statements)

References 6 publications

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“…Only Nikolaeva et al . 26,27 , as discussed below, reported a relationship between left or right handers and lipid metabolism. The liver connects with the hypothalamus through the autonomic nervous system 28 and particularly with the frontal cortex 20 .…”

Section: Discussionmentioning

confidence: 89%

Functional and neurometabolic asymmetry in SHR and WKY rats following vasoactive treatments

Segarra

Prieto-Gómez

Banegas

et al. 2019

Sci Rep

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A lateralized distribution of neuropeptidase activities in the frontal cortex of normotensive and hypertensive rats has been described depending on the use of some vasoactive drugs and linked to certain mood disorders. Asymmetrical neuroperipheral connections involving neuropeptidases from the left or right hemisphere and aminopeptidases from the heart or plasma have been suggested to play a role in this asymmetry. We hypothesize that such asymmetries could be extended to the connection between the brain and physiologic parameters and metabolic factors from plasma and urine. To assess this hypothesis, we analyzed the possible correlation between neuropeptidases from the left and right frontal cortex with peripheral parameters in normotensive (Wistar Kyoto [WKY]) rats and hypertensive rats (spontaneously hypertensive rats [SHR]) untreated or treated with vasoactive drugs such as captopril, propranolol and L-nitro-arginine methyl ester. Neuropeptidase activities from the frontal cortex were analyzed fluorometrically using arylamide derivatives as substrates. Physiological parameters and metabolic factors from plasma and urine were determined using routine laboratory techniques. Vasoactive drug treatments differentially modified the asymmetrical neuroperipheral pattern by changing the predominance of the correlations between peripheral parameters and central neuropeptidase activities of the left and right frontal cortex. The response pattern also differed between SHR and WKY rats. These results support an asymmetric integrative function of the organism and suggest the possibility of a different neurometabolic response coupled to particular mood disorders, depending on the selected vasoactive drug.

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Section: Discussionmentioning

confidence: 89%

Functional and neurometabolic asymmetry in SHR and WKY rats following vasoactive treatments

Segarra

Prieto-Gómez

Banegas

et al. 2019

Sci Rep

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show abstract

“…On the other hand, the socioeconomic implications of a deeper understanding of brain asymmetry and its neurovisceral integration could predict and, when appropriate, prevent neuropathologies or behavioral deviations. The greater or lesser incidence of left or right neuropathologies can derive from alterations in the general asymmetric processing of the organism, including the asymmetric bidirectional connection between the brain and the peripheral tissues [73][74][75][76][77][78].…”

Section: Neuropathologies and Brain Asymmetrymentioning

confidence: 99%

Brain Asymmetry: Towards an Asymmetrical Neurovisceral Integration

et al. 2021

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Despite the ancestral evidence of an asymmetry in motor predominance, going through the inspiring discoveries of Broca and Wernicke on the localization of language processing, continuing with the subsequent noise coinciding with the study of brain function in commissurotomized patients—and the subsequent avalanche of data on the asymmetric distribution of multiple types of neurotransmitters in physiological and pathological conditions—even today, the functional significance of brain asymmetry is still unknown. Currently, multiple evidence suggests that functional asymmetries must have a neurochemical substrate and that brain asymmetry is not a static concept but rather a dynamic one, with intra- and inter-hemispheric interactions between its various processes, and that it is modifiable depending on changing endogenous and environmental conditions. Furthermore, based on the concept of neurovisceral integration in the overall functioning of an organism, some evidence has emerged suggesting that this integration could be organized asymmetrically, using the autonomic nervous system as a bidirectional communication pathway, whose performance would also be asymmetric. However, the functional significance of this distribution, as well as the evolutionary advantage of an asymmetric nervous organization, is still unknown.

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“…Mujagić et al [29] evaluated symmetry, asymmetry, and hypoplasia of intracranial carotid arteries and found that in 94.6% of men and 93.4% of women this artery was symmetrical. Interestingly, the functional asymmetry of the brain may predispose to coronary atherosclerosis [30]. Also, the asymmetry of the stenotic artery region is correlated with characteristic sound emission and its variations [31].…”

Section: Other Arteriesmentioning

confidence: 99%

Symmetry and asymmetry in atherosclerosis

Kolaszyńska,

Lorkowski

2023

Int J Occup Med Environ Health.

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Atherosclerosis remains the main cause of death worldwide. Most important issues concerning atherosclerosis are hemodynamics and how it affects plaque prevalence and distribution, as well as the symmetry and asymmetry of vasculature and plaques. To present the symmetry in the vascular system an analysis of PubMed and MEDLINE databases was performed. As of February 21, 2023, the results were as follows: for "symmetry" AND "atherosclerosis" there were 47 results; for "symmetry" AND "atherosclerotic lesions" -20 results; for "symmetry" AND "artery stenosis" -82 results; for "asymmetry" AND "atherosclerosis" -87 results. Not without meaning are preventive measures. In the light of the Fourth Industrial Revolution artificial intelligence (AI) solutions help to develop new tools outperforming already existing cardiovascular risk scales. The aim of this paper is to present a current view on symmetry within vasculature and atherosclerosis as well as present a new approach to assess individuals' cardiovascular risk in accordance with precision medicine assumptions. Symmetry and asymmetry within the human vascular system play a crucial role in understanding of arterial diseases, including atherosclerosis. Moreover, it is unavoidable to use AI in cardiovascular risk stratification.

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Prognosis of myocardial infarction and brain functional asymmetry

Cited by 5 publications

References 6 publications

Functional and neurometabolic asymmetry in SHR and WKY rats following vasoactive treatments

Functional and neurometabolic asymmetry in SHR and WKY rats following vasoactive treatments

Brain Asymmetry: Towards an Asymmetrical Neurovisceral Integration

Symmetry and asymmetry in atherosclerosis

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