Prognosis of Lymphomatoid Papulosis

Frequency and Risk Factors for Associated Lymphomas in Patients With Lymphomatoid Papulosis

“…Indeed, the rate of detection of a monoclonal TCR gene rearrangement in LyP lesions at the time of diagnosis was 83% and 80%, respectively, among cases that were further associated with a systemic (n 5 7) or a skin (n 5 14) lymphoma during follow-up. Moreover, only 2 of the 22 patients with a negative TCR gene Because associated lymphomas occurring after diagnosis of LyP arose after a rather long median delay of 5 years, our results emphasize the need for prolonged follow-up of patients with LyP who have a cutaneous T-cell clone, as previously highlighted by Gruber et al [19]. Indeed, 25% of associated cutaneous or systemic lymphomas occurred after a very long delay of 6.5 years and 13 years, respectively, following diagnosis of LyP (Fig.…”

“…Diagnosis may precede or be concomitant with that of LyP, or occur during the course of LyP [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] The exact frequency of the association between LyP and another lymphoma remains unclear in the literature. It varies from the commonly cited rates of 10%-20% up to 40% and even 60% in some recent studies [3,[7][8][9][10][11][12][13][14][15][16][17][18][19][20]. This discrepancy led Gruber et al [19] to reassess the cumulative risk of developing an associated lymphoma in patients with LyP on the basis of the largest series [8,[12][13][14].…”

“…It varies from the commonly cited rates of 10%-20% up to 40% and even 60% in some recent studies [3,[7][8][9][10][11][12][13][14][15][16][17][18][19][20]. This discrepancy led Gruber et al [19] to reassess the cumulative risk of developing an associated lymphoma in patients with LyP on the basis of the largest series [8,[12][13][14]. They observed an extremely high 80% rate of association after a 20-to 30-year follow-up period, leading them to recommend long-term follow-up in patients with LyP.…”

Lymphomatoid Papulosis in a Patient with Crohnʼs Disease Treated with Infliximab

“…3 Nevertheless, up to 20% of children with LP may progress to other cutaneous lymphomas (such as anaplastic large T-cell lymphoma or mycosis fungoides) 4 and there is a 50% cumulative risk of developing cutaneous lymphoma 25 years after the initial diagnosis of LP is made. 5 LP is most frequently reported in immunocompromised patients, especially those with solid organ or bone marrow transplantation. An LP-like eruption has been described in 1 patient on anti-TNF therapy (adalimumab) for rheumatoid arthritis.…”

High Soluble CD30, CD25, and IL-6 May Identify Patients with Worse Survival in CD30+ Cutaneous Lymphomas and Early Mycosis Fungoides

“…(Bekkenk et al, 2000) Most patients with CD30CLDP have an excellent prognosis, but up to 20% progress to systemic involvement or develop a second lymphoma such as mycosis fungoides (MF) or Hodgkin lymphoma (HL). (Bekkenk et al, 2000; (Gruber et al, 2006). At presentation, the natural history of CD30CLDP is often not apparent and may be modified by subsequent molecular/genetic events (Kadin, 2006).…”