Prognosis of lung cancer associated with cystic airspaces: A propensity score matching analysis

Shen, Ye; Zhang, Yunfei; Guo, Yanhua; Li, Weitong; Huang, Yan; Wu, Tong; Jiang, Gening; Dai, Jie

doi:10.1016/j.lungcan.2021.07.003

Cited by 8 publications

(10 citation statements)

References 16 publications

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“…According to Mascalchi and his colleges' classi cation, lung cancer with cystic airspaces were divided into four types (Type I: nodule abuts the wall of the cystic airspace; Type II: nodule protrudes from the vesicle wall into the vesicle lumen; Type III: the wall of the cystic airspace is partial or complete thickened; Type IV: several small cystic airspaces with ground glass or consolidation consist of a large vesicle). [14] The prognosis of Type III cystic airspace was poor, [15] which was in consistent with our case whose left lower pulmonary nodule changed from type III to type II. Two months after the second surgery, we found a suspected metastatic pleural effusion.…”

Section: Discussionsupporting

confidence: 87%

Synchronous double primary lung cancer with cystic airspaces: a case report and literature review

Wang

et al. 2022

Preprint

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Background: Synchronous double primary lung cancer (SDPLC) is the most common type in multiple primary lung cancer (MPLC), which is a rare type of lung cancer. Lung cancer combined with cystic airspaces is relatively rare in imaging manifestation. Case presentation: Here, we reported a case with SDPLC which consisted of squamous cell carcinoma and mucinous adenocarcinoma with cystic airspaces. A new solid nodule developed form cystic airspaces in the left lower lung in three months after the right inferior lung cancer radical surgery. Left pleural effusion appeared in two months after the second left inferior lung cancer radical surgery. The patient died of severe immune-related pneumonitis induced by Camrelizumab in the fourth cycle of postoperative treatment. Conclusion: Synchronous double primary lung cancer with cystic airspaces have never been reported before, and no SMPLC cases with rapidly and poorly prognosis were reported. Therefore, we must pay more attention to the rapid progress of mucinous adenocarcinoma with cystic airspaces.

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Section: Discussionsupporting

confidence: 87%

Synchronous double primary lung cancer with cystic airspaces: a case report and literature review

Wang

et al. 2022

Preprint

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“…This is consistent with the dramatically increasing rate of node involvement along this progression towards more substantial solid components (Figure 3). Other studies corroborate this (54).…”

Section: Long-term Outcomessupporting

confidence: 72%

Lung cancer with air lucency: a systematic review and clinical management guide

Detterbeck¹,

Kumbasar²,

Li³

et al. 2023

J Thorac Dis

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Background: Lung cancers with air lucency are poorly understood, often recognized only after substantial progression.Methods: From a systematic review (PubMed and EMBASE, 2000-2022, terms related to cystic, cavitary, bulla, pseudocavitary, bubble-like, date 10-30-2022) 49 studies were selected using broad inclusion criteria (case series of ≥10 cases up to trials and reviews). There was no source of funding. Primary evidence relevant to clinical management issues was assembled. Because data was available only from heterogeneous retrospective case series, meta-analysis and formal risk-of-bias assessment was omitted. A framework was developed to guide clinical management based on the available data.Results: Demographic, smoking and histologic differences suggest that cystic, cavitary and bullous lung cancers with air lucency may be distinct entities; insufficient data leaves it unclear whether this also applies to pseudocavitary (solid) or bubble-like (ground glass) cancers. Annual observation of irregular thinwalled cysts is warranted; a surgical diagnosis (and resection) is justified once a solid component appears because subsequent progression is often rapid with markedly worse outcomes. Bubble-like ground glass lesions should be managed similarly. Cavitary lesions must be distinguished from infection or vasculitis, but generally require needle or surgical biopsy. Pseudocavitary lesions are less well studied; positron emission tomography may be useful in this setting to differentiate scar from malignancy. Further research is needed because these conclusions are based on interpretation of retrospective case series. Conclusions:The aggregate of available evidence suggests a framework for management of suspected lung cancers with air lucency. Greater awareness, earlier detection, and aggressive management once a solid component appears are needed. This review and framework should facilitate further research; questions include whether the suggested entities and proposed management are borne out and should involve clearly defined terms and outcomes related to progression and treatment. In summary, a conceptual understanding is emerging from interpretation of available data about a previously poorly understood topic; this should improve patient outcomes.

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“…This is in contrast to the human studies evaluating histopathological features which demonstrated: poor differentiation, high proliferation activity and less-frequent abnormalities of p53 tumour suppression gene compared with neoplasia not-associated with bullae (Hanaoka et al 2002). Furthermore, molecular testing has identified the presence of several mutations, with EGFR and KRAS genes being the most commonly affected (Fintelmann et al 2017, Snoeckx et al 2019, Mendoza et al 2021, Shen et al 2021, Snoeckx et al 2021. The prognosis of lung carcinoma arising from emphysematous bulla does not appear to be worse than those non-associated with emphysematous bulla (Hanaoka et al 2002).…”

Section: Discussionmentioning

confidence: 64%

“…Another study comparing the survival outcome among different subtypes concluded that type III lesions may exhibit the worst survival rate (Shen et al . 2021).…”

Section: Discussionmentioning

confidence: 99%

“…This observation suggested that the frequency of tumours associated with cystic airspaces may be underestimated by detection of the disease at an advanced stage when the air-filled component has disappeared. Another study comparing the survival outcome among different subtypes concluded that type III lesions may exhibit the worst survival rate (Shen et al 2021).…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary carcinoma associated with cystic airspaces in two dogs

Bello

Anselmi

Frau

et al. 2021

J of Small Animal Practice

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Malignant pulmonary neoplasia associated with cystic airspaces is a well-recognised disease entity in humans. Two elderly dogs, previously diagnosed with a solitary emphysematous bulla, presented with non-specific clinical signs. At presentation, pulmonary auscultation was unremarkable. In both cases, thoracic CT demonstrated the transformation of the cystic airspace lesions characterised by a progressive increase of the solid component and reduction of the air component. Cytological evaluation and subsequent surgical excision followed by histopathology confirmed pulmonary carcinoma in both cases. These two cases represent the first demonstration of possible malignant transformation of pulmonary cystic airspace in dogs. Veterinarians should consider neoplastic transformation as a differential diagnosis in cases of cystic airspaces, particularly cases with features including thickening or irregularity of the wall, associated soft-tissue nodules or solid and non-solid tissue intermixed within clusters of multiple cystic airspaces. Ongoing monitoring of cystic airspace lesions through diagnostic imaging is recommended.

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Prognosis of lung cancer associated with cystic airspaces: A propensity score matching analysis

Cited by 8 publications

References 16 publications

Synchronous double primary lung cancer with cystic airspaces: a case report and literature review

Synchronous double primary lung cancer with cystic airspaces: a case report and literature review

Lung cancer with air lucency: a systematic review and clinical management guide

Pulmonary carcinoma associated with cystic airspaces in two dogs

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