Prognosis of hepatoid yolk sac tumor in women: what's up, Doc?

Rittiluechai, Kristsanamon; Wilcox, Rebecca; Lisle, Jennifer W.; Everett, Elise; Wallace, H. James; Verschraegen, Claire F.

doi:10.1016/j.ejogrb.2013.12.029

Cited by 11 publications

(4 citation statements)

References 27 publications

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“…However, the histological examination did not support this diagnosis. Immunohistochemically, the tumor cells expressed Hep Par-1, glypican 3 and AFP; this immunoprofile is compatible with hepatocellular carcinoma (HCC), hepatoid adenocarcinoma (HAC), as well as hepYST (Table II) (10). Hep Par-1 is expressed in normal and neoplastic hepatocytes and has been used to confirm hepatoid differentiation.…”

Section: Discussionmentioning

confidence: 95%

“…YSTs are rare, aggressive tumors, occurring mainly in young adults, with a peak incidence at 21 years (10,11). YSTs arise most commonly in the gonads, but extragonadal sites of origin are reported in 24% of the cases (11).…”

Section: Discussionmentioning

confidence: 99%

“…hepYSTs are exceedingly rare, with only 32 reported cases in the English medical literature to date (10). The majority of these tumors arise from the ovary, whereas only single cases with an extraovarian origin are described.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation: A case report

Zeremski

Mawrin

Fischer

et al. 2016

Molecular and Clinical Oncology

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Yolk sac tumors (YSTs) are rare aggressive tumors, arising most commonly in the gonads and occurring mainly in young adults. We herein report a case of an extragonadal YST with hepatoid differentiation localized in the brain and lung. A 41-year old man presented to our hospital with a generalized seizure. A head computed tomography and magnetic resonance imaging examination revealed a large mass in the left occipital lobe with associated edema. Following complete resection, the histopathological examination revealed that the mass was a highly malignant epithelial tumor with a hepatoid pattern. The serum lactate dehydrogenase and α-fetoprotein levels were elevated. Additional diagnostic imaging revealed a lesion in the upper lobe of the right lung, but no other tumor manifestations. Based on the clinical and immunohistochemical characteristics, hepatocellular carcinoma and hepatoid adenocarcinoma were excluded and the diagnosis of extragonadal hepatoid YST was established. A multimodal therapeutic approach (high-dose chemotherapy with autologous stem cell transplantation, radiation and surgery) was applied; however, the patient succumbed to refractory disease 10 months after the diagnosis. Therefore, the diagnosis and treatment of hepatoid YST is an interdisciplinary challenge.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation: A case report

Zeremski

Mawrin

Fischer

et al. 2016

Molecular and Clinical Oncology

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“…However, hepatoid differentiation of YST indicates a poor prognosis. 14 Recently, a retrospective study of 519 patients with GCTs showed that the tumor site, age ≥11 years, and stage IV disease were significant predictors of poor survival. Elevated serum levels of AFP ≥10,000 ng/mL was associated with a worse outcome, while pure YST was associated with better outcomes.…”

Section: Discussionmentioning

confidence: 99%

Primary yolk sac tumor of the gluteus: a case report and literature review

Jiang

Zhang

et al. 2016

OTT

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Yolk sac tumor (YST) is a common malignant primitive germ cell tumor that often exhibits differentiation into endodermal structures. They most commonly occur in childhood and adolescence and are rare after the age of 40 years. Derived from the yolk sac during the embryonic period, YSTs can occur in the gonads and germ cells because the tumor cells migrate from the yolk sac toward the gonads. Here, we present a rare case of primary gluteus YST in a 3-year-old girl. She received BEP chemotherapy (bleomycin + etoposide + cisplatin) after surgical resection. There was no evidence of recurrence 7 months after primary treatment.

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Germ Cell Tumors of the Ovary

Maniar¹,

Vang²

2018

Blaustein's Pathology of the Female Genital Tract

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Prognosis of hepatoid yolk sac tumor in women: what's up, Doc?

Cited by 11 publications

References 27 publications

Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation: A case report

Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation: A case report

Primary yolk sac tumor of the gluteus: a case report and literature review

Germ Cell Tumors of the Ovary

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