Prognosis of Adenosquamous Carcinoma Compared With Adenocarcinoma in Uterine Cervical Cancer: A Systematic Review and Meta-Analysis of Observational Studies

Lee, Jung‐Yun; Lee, Chulmin; Hahn, Seokyung; Kim, Min A; Kim, Hee Seung; Chung, Hyun Hoon; Kim, Jae Weon; Park, Noh Hyun; Song, Yong Sang

doi:10.1097/igc.0000000000000063

Cited by 35 publications

(23 citation statements)

References 30 publications

(13 reference statements)

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“…A Korean multicenter retrospective study (total n ¼ 1323; AC/ASC, n ¼ 255) reported that AC histology was associated with poor survival outcomes than SCC, and prognosis of ASC histology was closer to that of SCC histology [23]. Conversely, a meta-analysis reported that ASC may have poorer outcomes compared with AC of the cervix [24]. Our study demonstrated that ASC seemed slightly worse than AC in univariate analysis, but they were not significantly different on RFS and CSS in multivariate analyses (Tables 2 and 3).…”

Section: Discussionmentioning

confidence: 92%

Prognostic factors and adjuvant therapy on survival in early-stage cervical adenocarcinoma/adenosquamous carcinoma after primary radical surgery: A Taiwanese Gynecologic Oncology Group (TGOG) study

Twu

Liao

et al. 2016

Surgical Oncology

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Section: Discussionmentioning

confidence: 92%

Prognostic factors and adjuvant therapy on survival in early-stage cervical adenocarcinoma/adenosquamous carcinoma after primary radical surgery: A Taiwanese Gynecologic Oncology Group (TGOG) study

Twu

Liao

et al. 2016

Surgical Oncology

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“…Patients in the later stages of cervical cancer with invasion or metastasis have a significantly worse prognosis (29). Fewer than 20% of women with stage IV cervical cancer survive for ≥5 years (30).…”

Section: Discussionmentioning

confidence: 99%

Lipid raft localization of epidermal growth factor receptor alters matrix metalloproteinase-1 expression in SiHa cells via the MAPK/ERK signaling pathway

Zhang

Wang

et al. 2016

Oncology Letters

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Matrix metalloproteinase-1 (MMP-1) has been identified as an important participant in tumor invasion, metastasis and angiogenesis. The purpose of the present study was to investigate the effects of epidermal growth factor receptor (EGFR) localization to lipid rafts on signaling pathways involved in the regulation of MMP-1 expression in SiHa cells, a cervical cancer cell line. EGFR activation by EGF specifically induced MMP-1 expression at both the messenger RNA and protein levels. Additionally, it was observed that EGFR localized to lipid rafts, and that the redistribution of EGFR induced by lipid raft disruption strengthened EGF-induced MMP-1 expression. MMP-1 induction was blocked by the mitogen-activated protein kinase (MAPK) kinase inhibitors PD98059 and U0126. Our results suggested that lipid rafts provide a platform to inhibit EGFR regulation of MMP-1 in SiHa cells through the MAPK/extracellular signal-regulated kinase signaling pathway.

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“…In contrast, several studies reported poor survival for patients with ASC. Lee et al [16] demonstrated that ASC may have poorer outcomes compared with AC of the cervix in meta-analysis. Farley et al [17] observed an increased risk of death among patients with ASC histology, compared to those with AC histology.…”

Section: Discussionmentioning

confidence: 99%

“…However, some studies have shown that ASC histology is associated with a worse prognosis, compared to that of AC histology [16,17],other studies found that early-stage AC and ASC are more aggressive and have worse prognoses, compared to SCC [6,[18][19][20][21]. Given that only a few studies have directly compared outcomes between patients with AC and those with ASC [8,17], the relationship between histology findings (AC or ASC) and the outcome of cervical cancer remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Comparison of adenocarcinoma and adenosquamous carcinoma prognoses in Chinese patients with FIGO stage IB-IIA cervical cancer following radical surgery

Lou

Zhang

et al. 2020

Preprint

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Objective To compare adenocarcinoma (AC) and adenosquamous carcinoma (ASC) prognoses in patients with FIGO stage IB–IIA cervical cancer who underwent radical hysterectomy. Methods We performed a retrospective analysis of 240 patients with AC and 130 patients with ASC. Kaplan–Meier curves, Cox regression models, and log-rank tests were used for statistical analysis. Results Patients with ASC had higher frequencies of lymphovascular space invasion (LVSI) and serum squamous cell carcinoma antigen (SCC-Ag) >5 ng/ml ( p =0.049 and p =0.013, respectively); moreover, they were much older ( P =0.029) than patients with AC. There were no clinically significant differences in overall survival between the groups. When stratified into three risk groups based on clinicopathological features, survival outcomes did not differ between patients with AC and those with ASC in the three risk groups. Multivariate analysis showed that lymph node metastasis (LNM) was an independent risk factor for RFS and OS in patients with AC and in patients with ASC. Carcinoembryonic antigen (CEA) >5 ng/ml and SCC-Ag >5 ng/ml were independent risk factors for RFS and OS in patients with AC. In addition, among those stratified as intermediate-risk, patients with ASC who received concurrent chemoradiotherapy (CCRT) had a significantly better RFS and OS ( P =0.036, and P =0.047 for RFS and OS, respectively). Conclusion We did not find evidence to suggest that AC and ASC subtypes of cervical cancer were associated with different survival outcomes. CCRT is beneficial to survival for intermediate-risk-group patients with ASC, but not those with AC. Serum tumour markers can assist in evaluating prognosis and in providing additional information for patient-tailored therapy for cervical AC.

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Prognosis of Adenosquamous Carcinoma Compared With Adenocarcinoma in Uterine Cervical Cancer: A Systematic Review and Meta-Analysis of Observational Studies

Abstract: This meta-analysis suggests that ASC may have poorer outcomes compared with AC of the cervix.

Cited by 35 publications

References 30 publications

Prognostic factors and adjuvant therapy on survival in early-stage cervical adenocarcinoma/adenosquamous carcinoma after primary radical surgery: A Taiwanese Gynecologic Oncology Group (TGOG) study

Prognostic factors and adjuvant therapy on survival in early-stage cervical adenocarcinoma/adenosquamous carcinoma after primary radical surgery: A Taiwanese Gynecologic Oncology Group (TGOG) study

Lipid raft localization of epidermal growth factor receptor alters matrix metalloproteinase-1 expression in SiHa cells via the MAPK/ERK signaling pathway

Comparison of adenocarcinoma and adenosquamous carcinoma prognoses in Chinese patients with FIGO stage IB-IIA cervical cancer following radical surgery

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