Prognosis in schizophrenia: Individual differences in psychological response to a test dose of antipsychotic drug and their relationship to blood and saliva levels and treatment outcome

May, Philip R. A.; Putten, Theodore Van; Jenden, Donald J.; Yale, Coralee; Dixon, W. J.; Goldstein, Michael J.

doi:10.1016/0010-440x(81)90062-6

Cited by 8 publications

(3 citation statements)

References 12 publications

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“…In a series of reports, Van Putten, May and coworkers have observed that a schizophrenic patient's subjective response, measured 4 or 24 h after a test dose of chlorpromazine or thiothixene, was significantly related to eventual clinical outcome following sustained treatment while in hospital (May et al 1976(May et al , 1981Van Putten & May, 1978;Van Putten et al 1980a, b, 1981. Patients experiencing a dysphoric response, those who felt 'listless ', 'uptight', or who developed acute panic after the first dose, realized significantly less symptom remission at the end of hospital treatment than those who did not have an initial dysphoric response.…”

Section: Introductionmentioning

confidence: 99%

“…The present study is primarily concerned with the generalizability of findings of one group of investigators and their patients to an independent sample. Secondly, since early emergence of extrapyramidal involvement has been implicated in the development of subjective response (May et al 1976(May et al , 1981Van Putten & May, 1978;Van Putten et al 1980a, b, 1981, an important design consideration of this investigation was the random assignment of patients to two drugs with markedly different side effect profiles (chlorpromazine and haloperidol). The third area of attention is with the validity of the construct of 'subjective response'.…”

Section: Introductionmentioning

confidence: 99%

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Subjective response to neuroleptics and outcome in schizophrenia: a re-examination comparing two measures

1992

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SYNOPSISThe schizophrenic patient's early psychological response to neuroleptic treatment has been demonstrated to be a significant predictor of treatment response. The validity of the construct of subjective response is evaluated by comparison of two measures. Fifty-five recently admitted and unmedicated schizophrenic patients were randomly allocated to chlorpromazine or haloperidol. Subjective responses at 24 and 48 hours as assessed by two different scales, the Van Putten & May scale and the self-administered Drug Attitude Inventory, were strongly correlated with outcome at three weeks. Early emergence of extrapyramidal symptoms was not related to subjective response, but dysphoric patients had a greater incidence of EPS by the end of treatment than did non-dysphoric patients. The two measures showed high concordance in identification of early drug dysphoria.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Subjective response to neuroleptics and outcome in schizophrenia: a re-examination comparing two measures

1992

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“…Although antipsychotic drugs have greatly improved the outlook for individual patients since their availability in the mid-1950's [176][177][178][179][180][181] , patient adherence to prescribed antipsychotic medication is often dismal, greatly concerning clinicians, family members, and others involved [93][94][95][96] . The 'health belief model' 182 , originally advanced to elucidate adherence to vaccinations and preventive health care in general, may provide a helpful perspective on treatment adherence in patients with a psychotic disorder 183 .…”

Section: Aripiprazole -A New Dawn In Schizophrenia Treatment?mentioning

confidence: 99%

Connecting the dots : new perspectives on stress and psychosis

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Non‐Neurological Side‐Effects of Antipsychotic Drugs

Goff¹,

Shader²

2003

Schizophrenia

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Prognosis in schizophrenia: Individual differences in psychological response to a test dose of antipsychotic drug and their relationship to blood and saliva levels and treatment outcome

Cited by 8 publications

References 12 publications

Subjective response to neuroleptics and outcome in schizophrenia: a re-examination comparing two measures

Subjective response to neuroleptics and outcome in schizophrenia: a re-examination comparing two measures

Connecting the dots : new perspectives on stress and psychosis

Non‐Neurological Side‐Effects of Antipsychotic Drugs

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