Prognosis in pathology: Are we “prognosticating” or only establishing correlations between independent variables and survival? A study with various analytics cautions about the overinterpretation of statistical results

Marchevsky, Alberto M.; Diniz, Márcio A.; Manzoor, Daniel; Walts, Ann E.

doi:10.1016/j.anndiagpath.2020.151525

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…Differences in reporting and publishing standards, as well as an important publication overload in each of these fields, makes the accurate and timely inclusion of new evidence in a structured assessment to inform classification of a tumour difficult. [5][6][7] The WCT is an important route for the incorporation of non-commercial knowledge from diagnostic research into patient management, providing international standards and clinical guidance for pathologists and cancer researchers worldwide. Decisions for such a global reference tool need to be informed by the best available evidence, and the risk of incorporating misinformation into the clinical decision pathways has to be minimised.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

“…This model recognises the relevance of information from numerous fields when classifying tumours, and defines the challenge this represents for the editorial board. Differences in reporting and publishing standards, as well as an important publication overload in each of these fields, makes the accurate and timely inclusion of new evidence in a structured assessment to inform classification of a tumour difficult 5–7…”

Section: Introductionmentioning

confidence: 99%

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Understanding the use of evidence in the WHO Classification of Tumours: a protocol for an evidence gap map of the classification of tumours of the lung

et al. 2022

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IntroductionThere are gaps in the evidence base of tumour classification despite being essential for cancer diagnosis, treatment and patient care. The WHO in charge of the production of an updated international classification, the WHO Classification of Tumours (WCT), aims to adapt evidence gap map (EGM) methodology to inform future editions of the WCT, by providing a visual summary of the existing evidence.Methods and analysisBibliographical references used in the WCT fifth edition of Tumours of the Lung (Thoracic Tumours volume) will be used as search results of a literature search. A descriptive analysis of the cited evidence for tumour types and descriptors will be drafted and plotted in EPPI-Reviewer to develop a visual evidence map. The resulting EGM will reflect the number of cited studies in the size of the spheres, and the level of evidence by applying a four-colour code (red=low level evidence, orange=moderate level, green=high level and blue=unclassifiable). Overview of the findings will be provided in narrative form and a report will discuss the overall stage of cited research in the WCT and will include analysis of gaps, under-researched categories of tumour descriptors and pockets of low-level evidence.Ethics and disseminationNo ethics approval will be required as this is a study of previously published material. Findings of the EGM will be published and used to guide editors, stakeholders and researchers for future research planning and related decision-making, especially for the development of future editions of the WCT.PROSPERO registration numberCRD42022302327.

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Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Understanding the use of evidence in the WHO Classification of Tumours: a protocol for an evidence gap map of the classification of tumours of the lung

et al. 2022

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Analysis of Pollen Concentrations from Various Tree Pollen Types and Their Interrelation with Different Airborne Pollutants in the Madrid Region (Spain)

Chico-Fernández

Ayuga-Téllez

2022

Sustainability

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Several studies show that the interaction between airborne pollutants and pollen grains can lead to greater pollen allergenicity, and thus increase and exacerbate the incidence of pollinosis, all of which represents a major public health problem. This article analyses the possible influence of various airborne pollutants (O3, PM10 and PM2.5, NO2, CO and SO2) on the tree-type pollen grains of Cupressaceae, Olea, Platanus, Pinus, Ulmus and Populus. The 11 areas around the stations in the Madrid Region’s pollen monitoring network (Red Palinocam) were taken as a geographic reference for this study. The degree of interaction between airborne pollutants and pollen types was explored using the rank correlation analysis. O3 and NO2 are the pollutants with the highest rate of significant correlations with pollen types. Olea, Cupressaceae and Platanus—the most highly allergenic in this study—are among the pollen types with the greatest number of significant correlations with almost all the air pollutants in the different areas. This could point to a potential associative effect between both variables which would exacerbate the negative effects on public health.

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Prognosis in pathology: Are we “prognosticating” or only establishing correlations between independent variables and survival? A study with various analytics cautions about the overinterpretation of statistical results

Cited by 2 publications

References 24 publications

Understanding the use of evidence in the WHO Classification of Tumours: a protocol for an evidence gap map of the classification of tumours of the lung

Understanding the use of evidence in the WHO Classification of Tumours: a protocol for an evidence gap map of the classification of tumours of the lung

Analysis of Pollen Concentrations from Various Tree Pollen Types and Their Interrelation with Different Airborne Pollutants in the Madrid Region (Spain)

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