Prognosis in N2 NSCLC

Radical systematic mediastinal lymphadenectomy versus mediastinal lymph node sampling in patients with clinical stage IA and pathological stage T1 non-small cell lung cancer

“…Patients with large cell carcinoma and adenosquamous carcinoma had a lower 5-year OS than patients with either adenocarcinoma or squamous carcinoma, which may suggest the feasibility of some adjunctive treatments to them. Many studies indicate that lymph node metastasis meant a bad prognosis to patients with NSCLC (Vansteenkiste et al 1998;Friedel et al 2004), and we draw the similar conclusion as well. In multivariate analysis, lymph node metastasis was deWned as the only unfavorable prognostic factor by forward stepwise Cox regression.…”

Effect of 5-aza-2'-deoxycytidine on Cell Proliferation of Non-small Cell Lung Cancer Cell Line A549 Cells and Expression of the TFPI-2 Gene

“…Despite the intensive research carried out on this field and therapeutic advances, the overall prognosis of these patients remains unsatisfactory, with a 5-year overall survival rate of less than 15% (Sculier et al, 2008;Carvalho et al, 2009). In stage I to III NSCLC, the occurrence of extrathoracic metastasis also leads to a poor 5-year survival rate of 50% (Friedel et al, 2004). Surgery is the best curative therapeutic approach in the early stages.…”

Postoperative Radiation Therapy for Patients Who Have Resected Non–Small Cell Lung Cancer

“…Several more recent series attempted to determine in further detail the effect of the extent of nodal involvement on local control and survival [8]. Sawyer et al [9] reported retrospectively on several hundred patients who were resected at the Mayo Clinic.…”