Prognosis for babies born with fused eyelids.

Assessment of an Updated Neonatal Research Network Extremely Preterm Birth Outcome Model in the Vermont Oxford Network

“…Historically, signs from physical examination, such as fusion of the eyelids, were used to determine viability at extremely preterm gestations, although their utility has not been borne out. 34,35 The use of the combined 5 factors in the model was again found to outperform gestational age alone as a tool for predicting survival, 4 and the predictive benefits of a modelbased vs gestational age-based approach were demonstrated in the decision curve analysis. In the future, other methods, such as the use of biochemical markers of infant maturity, may enhance our ability to estimate infant outcomes.…”

“…The C statistic of the updated model was not substantially different from that observed when deriving the original model and in independent validations of that model and demonstrated the continued difficulty of estimating outcomes for extremely preterm infants at the time of birth. Historically, signs from physical examination, such as fusion of the eyelids, were used to determine viability at extremely preterm gestations, although their utility has not been borne out . The use of the combined 5 factors in the model was again found to outperform gestational age alone as a tool for predicting survival, and the predictive benefits of a model-based vs gestational age–based approach were demonstrated in the decision curve analysis.…”

Fused Eyelids in the Extremely Premature Infant: Multivariate Analysis of Survival and Outcome

“…A review of the current literature provides scant data in this regard. The few studies that have been reported either have not subjected the data to any statistical analysis 35 - 6 or have treated the data with the standard univariate chi-square analysis. 7 In this latter study, eyelid status and 1-minute Apgar scores were jointly analyzed to determine the combined effect on neonatal survival.…”