Prognosis Following Surgical Excision of Canine Cutaneous Mast Cell Tumors With Histopathologically Tumor-Free Versus Nontumor-Free Margins: A Retrospective Study of 31 Cases

Michels, Gina M.; Knapp, Deborah W.; DeNicola, Dennis B.; Glickman, Nita W.; Bonney, Patty L.

doi:10.5326/0380458

Cited by 103 publications

(173 citation statements)

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“…Tumor recurrence developed in a small number of dogs with completely excised, grade II, cutaneous mast cell tumors [21,27], suggesting that a complete excision can reduce recurrence. In a prior study, the frequency of recurrence in complete surgical excision within 24 months postoperatively was significantly lower than in incomplete surgical excision [13]. These previous findings corresponded with our data.…”

Section: Discussionsupporting

confidence: 82%

“…The frequency of recurrence in the complete surgical excision cases was significantly lower than in incomplete surgical excision during 24 months following surgery [13]. In contrast, the percentage of recurrence of incomplete excision cases of grade II mast cell tumors was only 50% [13], so about 50% of incomplete excision cases did not show recurrence. From these facts, many veterinary practitioners would like other more accurate prognostic factors in incomplete excision cases.…”

mentioning

confidence: 88%

“…In grade II tumors, a complete surgical margin accurately predicted a good prognosis [21,27]. The frequency of recurrence in the complete surgical excision cases was significantly lower than in incomplete surgical excision during 24 months following surgery [13]. In contrast, the percentage of recurrence of incomplete excision cases of grade II mast cell tumors was only 50% [13], so about 50% of incomplete excision cases did not show recurrence.…”

mentioning

confidence: 90%

“…The clinical course of each dog with CCMT varied from benign to highly malignant. Various prognostic factors have been studied, including clinical stage, surgical resection [13,21,27], kinetic parameters (Ki-67 [1,19], BrDU [19], PCNA [23], AgNOR [11]), DNA ploidy [2], intratumoral vessel density [18], p53 [7,8], KIT [9,25,26], nuclear morphometry [24], tumor depth [10] and location [4].…”

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confidence: 99%

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Prognostic Significance of Surgical Margin, Ki-67 and Cyclin D1 Protein Expression in Grade II Canine Cutaneous Mast Cell Tumor

et al. 2007

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ABSTRACT. The prognosis for canine cutaneous mast cell tumor (CCMT) is thought to be correlated with histopathological grading. However, the wide variety of histopathologic types of grade II is one of the most troublesome and difficult points for prognosis. The objective of this study is to determine the prognostic value of surgical margin, ki-67 and cyclin D1 protein expression in grade II tumor. Surgically resected specimens of solitary grade II CCMT from 48 dogs with follow-up periods over 360 days (median was 1080 days) were used in this study. The expression of cyclin D1 and ki-67 proteins was determined by morphometrically using slides stained immunocytochemically, and the correlations among the results, survival rate, and recurrence and/or metastasis rate of each dog were analyzed statistically. The recurrence and/or metastasis and mortality rate in the incomplete surgical excision group within 30 months postoperatively were higher than that of the complete surgical excision group. In the incomplete surgical excision group, dogs with low positive staining of ki-67 had a significantly better survival, but the recurrence and metastasis rate and ki-67 positivity failed to show a significant correlation. Only a small number of cases showed cyclin D1-positive tumor cells, but most of them had a poor outcome with a high recurrence rate. In grade II CCMT, incomplete excision induced a relatively high metastasis rate and poor prognosis. Ki-67 positivity is a marker for the estimation of overall survival in incomplete surgical excision cases. Cyclin D1 positivity was low and may not have a prognostic role. KEY WORDS: canine, cyclin D1, ki-67, mast cell tumor, skin.J. Vet. Med. Sci. 69(11): 1117-1121, 2007 Cutaneous mast cell tumors (CCMT) are the most common round cell neoplasm in dogs, accounting for 7 to 21% of all skin tumors [12,16] The most accurate and commonly used prognostic factor is histological grade. Among the histological grading systems, Patnaik's method has been the most commonly used around the world [3,17], and the prognostic significance of this method was confirmed in other studies [1,7,8,23]. According to Patnaik's system, CCMT is classified into 3 categories on the basis of morphologic grading: grade I tumors are the most differentiated and have a good prognosis, grade III tumors are poorly differentiated with a poor prognosis, and grade II shows an intermediate differentiation with good to poor prognosis. Using this grading system, the prognosis of grade I and III tumors can be readily determined well [17]. However, other parameters have been needed for precise prognosis of grade II tumors, which have shown an inconsistent prognosis, the marked degree of inter-observer variation and accounted for 40% or 59% of CCMT [15,17].The relationships among surgical margin and prognosis or recurrence have been reported by several researchers. In grade II tumors, a complete surgical margin accurately predicted a good prognosis [21,27]. The frequency of recurrence in the complete surgical excision cases w...

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confidence: 82%

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confidence: 88%

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confidence: 90%

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confidence: 99%

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Prognostic Significance of Surgical Margin, Ki-67 and Cyclin D1 Protein Expression in Grade II Canine Cutaneous Mast Cell Tumor

et al. 2007

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“…However, this finding was not noticed in this study, and was also not observed in the study by Miller et al (2014). In a study conducted by Michels et al (2002), the likelihood of recurrence in MCT with evidence of incomplete surgical margins was not higher than those with clean margins. This may be the result of failure in the assessment of the surgical margins, or even by reduced importance of the extent of the surgery in the local control of canine MCT.…”

Section: Discussioncontrasting

confidence: 48%

Outcome of adjuvant chemotherapy with lomustine, vinblastine and chlorambucil on management of canine mast cell tumour of high to intermediate risk

Horta

Lavalle

Costa

et al. 2017

Arq. Bras. Med. Vet. Zootec.

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In spite of the many available protocols, the use of chemotherapy for the management of canine mast cell tumours (MCT) remains empirical, and there is lack of criteria for the choice of protocol and definition of patients who may benefit from treatment. The objective of this study was to evaluate the outcome of dogs with MCT after adjuvant chemotherapy according to the risk of recurrence or metastasis proposed on the literature. This prospective study included 89 followed up dogs with prognosis assesment including clinical, histological, immunohistochemical and genetic features of canine MCT. Patients were grouped according to risk of recurrence and metastasis and recommended treatment with lomustine followed by chlorambucil if considered at high-risk, or vinblastine followed by chlorambucil if a patient was at intermediate risk. Outcome was defined by disease-free interval (DFI) and overall survival (OS) estimated by Kaplan-Meier curve. Adjuvant lomustine was useful for control of canine MCT of high-risk of recurrence or metastasis, but only when sequentially associated to chlorambucil with a DFI of 686 days and not reached OS.

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Mast Cell Tumors

Gross¹,

Ihrke²,

Walder³

et al. 2005

Skin Diseases of the Dog and Cat

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Prognosis Following Surgical Excision of Canine Cutaneous Mast Cell Tumors With Histopathologically Tumor-Free Versus Nontumor-Free Margins: A Retrospective Study of 31 Cases

Cited by 103 publications

References 6 publications

Prognostic Significance of Surgical Margin, Ki-67 and Cyclin D1 Protein Expression in Grade II Canine Cutaneous Mast Cell Tumor

Prognostic Significance of Surgical Margin, Ki-67 and Cyclin D1 Protein Expression in Grade II Canine Cutaneous Mast Cell Tumor

Outcome of adjuvant chemotherapy with lomustine, vinblastine and chlorambucil on management of canine mast cell tumour of high to intermediate risk

Mast Cell Tumors

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