Prognosis and predictors of outcome of refractory generalized convulsive status epilepticus in adults treated in neurointensive care unit

Vooturi, Sudhindra; Jayalakshmi, Sita; Sahu, Sambit; Mohandas, Sukhada

doi:10.1016/j.clineuro.2014.07.038

Cited by 39 publications

(27 citation statements)

References 25 publications

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“…In most developing countries, CNS infection was the most common cause or comorbid condition of SE [9][10][11], while stroke accounted for 45% of adult patients with SE in the developed countries, particularly in the elderly patients [12,13]. In most developing countries, CNS infection was the most common cause or comorbid condition of SE [9][10][11], while stroke accounted for 45% of adult patients with SE in the developed countries, particularly in the elderly patients [12,13].…”

Section: Discussionmentioning

confidence: 99%

Incidences and outcomes of status epilepticus: A 9-year longitudinal national study

Tiamkao

Pranboon

Thepsuthammarat

et al. 2015

Epilepsy & Behavior

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Section: Discussionmentioning

confidence: 99%

Incidences and outcomes of status epilepticus: A 9-year longitudinal national study

Tiamkao

Pranboon

Thepsuthammarat

et al. 2015

Epilepsy & Behavior

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“…One hundred and twenty-six people with status epilepticus who presented in a neurological intensive care unit were evaluated [143]. Eighty-one (64 %) were classified as having non-refractory status epilepticus.…”

Section: Bacterial Infections As a Cause Of Epilepsymentioning

confidence: 99%

“…Eighty-one (64 %) were classified as having non-refractory status epilepticus. Those with refractory status were more likely to have viral encephalitis (31 %) than those with non-refractory SE (6 %) [143]. People with encephalitis are more likely to develop later seizures [15].…”

Section: Bacterial Infections As a Cause Of Epilepsymentioning

confidence: 99%

Infections, inflammation and epilepsy

et al. 2015

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Epilepsy is the tendency to have unprovoked epileptic seizures. Anything causing structural or functional derangement of brain physiology may lead to seizures, and different conditions may express themselves solely by recurrent seizures and thus be labelled "epilepsy." Worldwide, epilepsy is the most common serious neurological condition. The range of risk factors for the development of epilepsy varies with age and geographic location. Congenital, developmental and genetic conditions are mostly associated with the development of epilepsy in childhood, adolescence and early adulthood. Head trauma, infections of the central nervous system (CNS) and tumours may occur at any age and may lead to the development of epilepsy. Infections of the CNS are a major risk factor for epilepsy. The reported risk of unprovoked seizures in populationbased cohorts of survivors of CNS infections from developed countries is between 6.8 and 8.3 %, and is much higher in resource-poor countries. In this review, the various viral, bacterial, fungal and parasitic infectious diseases of the CNS which result in seizures and epilepsy are discussed. The pathogenesis of epilepsy due to brain infections, as well as the role of experimental models to study mechanisms of epileptogenesis induced by infectious agents, is reviewed. The sterile (noninfectious) inflammatory response that occurs following brain insults is also discussed, as well as its overlap with inflammation due to infections, and the potential role in epileptogenesis. Furthermore, autoimmune encephalitis as a cause of seizures is reviewed. Potential strategies to prevent epilepsy resulting from brain infections and non-infectious inflammation are also considered.

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“…Systemic complications of SE can determine long‐term morbidity and mortality, including cardiomyopathy, pulmonary edema, and renal failure 11, 81. It remains unclear how medical treatments affect long‐term outcome of SE.…”

Section: Factors Affecting Outcomementioning

confidence: 99%

Long‐term outcomes of status epilepticus: A critical assessment

et al. 2018

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SummaryWe reviewed 37 studies reporting long‐term outcomes after a status epilepticus (SE) episode in pediatric and adult populations. Study design, length of follow‐up, outcome measures, domains investigated (mortality, SE recurrence, subsequent epilepsy, cognitive outcome, functional outcome, or quality of life), and predictors of long‐term outcomes are summarized. Despite heterogeneity in the design of prior studies, overall risk of poor long‐term outcome after SE is high in both children and adults. Etiology is the main determinant of outcome, and the effect of age or SE duration is often difficult to distinguish from the underlying cause. The effect of the treatment on long‐term outcome after SE is still unknown.

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Prognosis and predictors of outcome of refractory generalized convulsive status epilepticus in adults treated in neurointensive care unit

Cited by 39 publications

References 25 publications

Incidences and outcomes of status epilepticus: A 9-year longitudinal national study

Incidences and outcomes of status epilepticus: A 9-year longitudinal national study

Infections, inflammation and epilepsy

Long‐term outcomes of status epilepticus: A critical assessment

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