Prognosis and Outcome of Cerebral Sinus Venous Thrombosis—A Multicenter Cohort Study

Simaan, Naaem; Honig, Asaf; Hallevi, Hen; Seyman, Estelle; Rotschild, Ofer; Assayag, Einor Ben; Filioglo, Andrei; Peretz, Shlomi; Mendel, Rom; Barnea, Rani; Auriel, Eitan; Aladdin, Shorooq; Orion, David; Darawsha, Khalil; Shbat, Fadi; Leker, Ronen R.; Molad, Jeremy

doi:10.1155/2023/8016006

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Data from the Israeli CSVT study was retrospectively analyzed. This is an ongoing observational study, continuously enrolling adult patients diagnosed with non-traumatic CSVT that were admitted to seven comprehensive stroke centers in Israel ( 18 ). The study was approved by the ethical committees in each of the participating centers.…”

Section: Methodsmentioning

confidence: 99%

“…All imaging studies were interpreted by experienced neuroradiologists and experienced stroke neurologists. The site and location of the occluded venous were recorded as previously described ( 9 , 18 ). Multiple vein/sinus involvement was defined as involvement of more than one site, excluding continuous involvement of the transverse and sigmoid sinuses on the same side or cortical vein involvement.…”

Section: Methodsmentioning

confidence: 99%

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Efficacy and safety of Apixaban in the treatment of cerebral venous sinus thrombosis: a multi-center study

Simaan,

Metanis,

Honig

et al. 2024

Front. Neurol.

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BackgroundInformation regarding the safety and efficacy of specific direct oral anticoagulants (DOAC) in the treatment of cerebral sinus and venous thrombosis (CSVT) is scarce. Apixaban is one of the most frequently prescribed DOACs. Therefore, we aimed to compare the safety and efficacy of Apixaban with those of vitamin k antagonists (VKA) in patients with CSVT.MethodsProspective CSVT databases from seven academic medical centers were retrospectively analyzed. Patients treated with Apixaban were compared to those treated with VKA. Data on demographics, clinical presentations, risk factors, radiological and outcome parameters were studied.ResultsOverall, 403 patients were included in the analysis. Of them, 48 (12%) were treated with Apixaban, and 355 (88%) were treated with VKA. Rates of coagulopathies were significantly higher in the VKA-treated patients but no other differences between the groups were found in baseline characteristics and underlying etiology. No significant differences were found between groups in efficacy or safety parameters including the rates of recanalization, favorable outcomes, one-year mortality, seizures, intracranial hemorrhage or CSVT recurrences.ConclusionOur data suggests that Apixaban may be safe and effective for patients with CSVT. These results should be tested in prospective randomized clinical studies.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Efficacy and safety of Apixaban in the treatment of cerebral venous sinus thrombosis: a multi-center study

Simaan,

Metanis,

Honig

et al. 2024

Front. Neurol.

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Sex differences in clinical profile and risk factors of cerebral venous sinus thrombosis at a high-altitude area: A 10-year retrospective cross-sectional study

Zarimeidani,

Rahmati,

Mokary

et al. 2024

Medicine

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Cerebral venous sinus thrombosis (CVST) is an uncommon disorder with an increased mortality risk. Data on the sex-specific clinical profile and related factors can be practical in clinical diagnosis and management. Thus, we aimed to assess CVST characteristics in Shahrekord, the most elevated city among the centers of the provinces of Iran, referred to as the Roof of Iran. In this retrospective cross-sectional study, we reviewed the hospital records of 127 CVST patients between April 2013 and June 2023 to analyze the demographic characteristics, clinical profile, disease outcomes, and risk factors. STROBE guidelines were used to report this study. Females comprised 65.3% of the study. Females’ age was almost equal to male patients (37.51 ± 13.95 years vs 38.09 ± 16.18 years, P = .832), and more than half of the patients (59.1%) were married. Clinical characteristics showed no significant difference between the sexes. In contrast to males, females had multifarious risk factors. However, the main risk factors for both sexes were CVST and hypertension. Most patients had 1 sinus affected (55.9%), and the location of thrombosis was mainly in the right transverse sinus in males (38.63%) and superior sagittal sinus in females (33.73%). However, those with more than 2 affected sinuses were mostly women. Regarding radiological findings, sinusitis was significantly seen in men (18.18% vs 3.61%). Among laboratory data, females significantly had higher erythrocyte sedimentation rate levels than males (21.66 ± 24.39 vs 9.60 ± 8.55). This study indicates that among CVST patients, men have significantly higher occurrences of sinusitis, and higher levels of erythrocyte sedimentation rate were observed in women. However, no other significant differences were found. More extensive studies are essential to fully comprehend the sex-specific aspects of CVST.

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Evaluation of risk factors and clinical and radiological characteristics in cortical vein thrombosis accompanying cerebral venous sinus thrombosis

Dinç,

Ozpar,

Hakyemez

et al. 2024

Turk J Neurol

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Objectives: The study aimed to determine the clinical relevance of cortical vein thrombosis (CVT) accompanying cerebral venous sinus thrombosis (CVST) and to investigate the risk factors. Patients and methods: This retrospective study included 176 patients (52 males, 124 females; mean age: 41.8±14.5 years; range, 16 to 72 years) with CVST between January 2015 and January 2021. The radiological, demographic, and clinical features and risk factors of patients with and without CVT were com-pared. Results: When the clinical demographic and radiological features associated with CVT were evaluated; there was a significant relationship between age, clinical onset symptom, connective tissue disease, post-partum period, presence of hypercoagulopathy, superior sagittal sinus (SSS) thrombosis, transverse sinus thrombosis, sigmoid sinus thrombosis, non-hemorrhagic venous infarct, small juxtacortical hemorrhage and large parenchymal hematomas, time to diagnosis (days), and poor clinical outcome. When significant risk factors for CVT were analyzed by binary logistic regression, the post-partum period and SSS thrombosis were independent risk factors. Conclusion: In this study, the rate of CVT accompanying CVST was 30.7%, which is higher than the studies in the literature. Cortical vein thrombosis accompanying CVST is associated with parenchymal lesions and poor clinical outcome; SSS thrombosis and the postpartum period are independent risk factors. Multicenter prospective studies are recommended for more precise information.

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Prognosis and Outcome of Cerebral Sinus Venous Thrombosis—A Multicenter Cohort Study

Cited by 3 publications

References 26 publications

Efficacy and safety of Apixaban in the treatment of cerebral venous sinus thrombosis: a multi-center study

Efficacy and safety of Apixaban in the treatment of cerebral venous sinus thrombosis: a multi-center study

Sex differences in clinical profile and risk factors of cerebral venous sinus thrombosis at a high-altitude area: A 10-year retrospective cross-sectional study

Evaluation of risk factors and clinical and radiological characteristics in cortical vein thrombosis accompanying cerebral venous sinus thrombosis

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