Prognosis and immune function of Synaptotagmin-4 in gastric cancer and brain low-grade glioma

Abstract

Background Synaptotagmins (SYTs) are a family of proteins whose primary feature is the calcium sensor in vesicle transport and exocytosis. SYT4 is one of them, but the relationship between SYT4 and cancer remains unclear. We aim to explore the prognosis and immune function of SYT4 in gastric cancer and low-grade glioma. Methods These databases were used to study the immunological and prognostic role of SYT4 in cancers, including the Oncomine database, Kaplan-Meier plotter, GEPIA2, TIMER, and CGGA. Results The study suggested that the expression levels of SYT4 were lower in both gastric cancer and glioma, compared to the normal tissues. And SYT4 played a protective and harmful role in low-grade gliomas and gastric cancer, respectively. Moreover, we found that a difference between SYT4 expression and the levels of immune infiltration in stomach adenocarcinoma (STAD) and brain lower-grade glioma (LGG). Besides, after exploring the association between the expression levels of SYT4 and markers of immune cells in these two cancers, we found that markers of monocytes, M1/ M2, tumor-associated macrophages (TAMs), Treg cells and SYT4 expressions had an opposite correlation in STAD and LGG. Conclusions SYT4 had an effect on the prognosis of gastric cancer and glioma patients and was related to immune infiltration by regulating TAMs and Treg cells. SYT4 can be used as a prognostic biomarker for STAD and LGG.

Analysis of Breast Cancer Differences between China and Western Countries Based on Radiogenomics

“…For example, the expression of the SYT4 and CHGA genes is positively related to the square_firstorder_10Percentile. SYT4, which is mainly present in the Golgi body and cytosol of lymph nodes, belongs to the touch-binding protein (SYTs) family, which plays an essential part in the process of immune cells [ 48 , 49 ]. It is now known that SYT4 has a role in gastric adenocarcinoma and low-grade glioma and is associated with recurrence-free survival in BC [ 49 ].…”

“…SYT4, which is mainly present in the Golgi body and cytosol of lymph nodes, belongs to the touch-binding protein (SYTs) family, which plays an essential part in the process of immune cells [ 48 , 49 ]. It is now known that SYT4 has a role in gastric adenocarcinoma and low-grade glioma and is associated with recurrence-free survival in BC [ 49 ]. CHGA encodes pheochromophilin A, or parathyroid secretory protein.…”