Prognoses of Oral Basaloid Squamous Cell Carcinoma and Squamous Cell Carcinoma

Góes, Fernanda Costa Grizzo de Sampaio; Oliveira, Denise Tostes; Dorta, Regina Garcia; Nishimoto, Inês Nobuko; Landman, Gilles; Kowalski, Luiz Paulo

doi:10.1001/archotol.130.1.83

Cited by 45 publications

(36 citation statements)

References 20 publications

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“…Las células basaloides se disponen en lóbulos, láminas, cuerdas o islas y disposición periférica con la parte central de las islas compuestas de células escamosas, con mitosis anormal frecuente que sugiere un comportamiento agresivo, las células basaloides tienen citoplasma escaso, núcleos hipercromáticos o vesiculares prominentes ovalados con o sin nucleolos (1,8,13,21,23). Aparte de las características antes mencionadas, la metástasis a linfadenopatía regional es una de las características comunes del CCEB.…”

Section: Discussionunclassified

“…Sin embargo, de Sampaio Góes y cols. (13) reportaron que el pronóstico no difirió entre los pacientes con CCEB de la cavidad oral y aquellos con CCE convencional. Por lo tanto, una lesión rara como el CCEB debe ser reportada para la mejor comprensión de la naturaleza de tales tumores (33).…”

Section: Discussionunclassified

“…La inmunohistoquímica (IHQ) y la microscopía electrónica son ayudas para el diagnóstico diferencial histológico (10)(11)(12), marcadores inmunohistoquímicos como p63, Ki67, p16, y citoqueratinas AE1 / AE3 son valiosos para reflejar el comportamiento biológico de la CCEB y ayuda a distinguir de CCE convencional y otros tumores malignos (13)(14)(15)(16); como el carcinoma adenoide quístico (CAQ), carcinoma neuroendocrino (CNE) de células pequeñas y grandes, carcinoma escamoso no queratinizado (CENQ) y adenocarcinomas (10)(11)(12).…”

Section: Introductionunclassified

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Basaloid Squamous Cell Carcinoma of the Palate: Case Report

Oreamuno

2017

Odovtos - Int J Dent Sc

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RESUMENEl carcinoma de células escamosas basaloide (CCEB) es una variante poco común y agresiva del carcinoma de células escamosas (CCE), con predilección por el tracto aerodigestivo superior, siendo el paladar un sitio muy raro de desarrollo. Está constituido por un componentes basaloide y uno escamoso en proporciones variables, sin embargo, las características histopatológicas del CCEB se superponen con otras neoplasias. El diagnóstico con diversos marcadores inmunohistoquímicos como p63, Ki67, p16, y citoqueratinas AE1 / AE3 se han convertido en una necesidad para el especialista. El objetivo de este trabajo es presentar un caso de CCEB en paladar blando y evidenciar la importancia del apoyo en la inmunohistoquímica para un diagnóstico histopatológico precoz. Se presenta además una revisión de literatura en cuanto a esta patología. PALABRAS CLAVE

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Section: Discussionunclassified

Section: Introductionunclassified

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Basaloid Squamous Cell Carcinoma of the Palate: Case Report

Oreamuno

2017

Odovtos - Int J Dent Sc

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“…Basaloid squamous cell carcinoma (BSCC) is a rare variant of SCC. BSCC may present as a more aggressive, poor-prognostic lesion compared to SCC; however, there is controversy regarding the true aggressive behavior of this variant [3][4][5][6], and some studies have demonstrated the effect of HPV infection on BSCC of the head and neck region [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

p53 and p16 expression in oral cavity squamous cell and basaloid squamous cell carcinoma

et al. 2018

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Purpose The true aggressive behavior of oral cavity BSCC compared to SCC has been debated, and the study of disturbances in cell cycle proteins may help understand the biological behavior in both variants. The aim of this study was to investigate the p53 and p16 status in 32 SCC and 16 BSCC of oral cavity. Methods Immunohistochemistry was used to assess these proteins' status. The association between p53 and p16 with clinicopathological features and prognostic value were evaluated. Results A high prevalence of p53 disruption was observed in both variants (84.4% of 32-SCC and 81.2% of 16-BSCC; p = 0.78). The BSCC showed a higher prevalence of high p16 expression (86.7% of 15) when compared to SCC (61.3% of 31); however, this difference did not reach statistical significance (p = 0.08). In the SCC variant, cases with high p16 expression showed a lower overall survival. Protein p53 showed association with tobacco use, but with no other clinicopathological features. Conclusions Our results suggest that p53 and p16 cell cycle disruptions are common findings in oral cavity SCC, as well as in BSCC. A higher prevalence of p16 overexpression in oral BSCC cases may be related to carcinogenesis process.

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“…It is generally thought that BSCC is more aggressive than conventional SCC when matched stage for stage, though some authors maintained a similar course and prognosis of BSCC as conventional SCC (4). The tumor could be diffused with adenoid cystic carcinoma, neuroendocrine carcinoma, small cell undifferentiated carcinoma or salivary basal cell adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

Basaloid Squamous Cell Carcinoma of Gingiva: a New Case Report with Immunohistochemical Study

et al. 2013

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Basaloid squamous cell carcinoma（BSCC）of the gingiva other than the tongue or floor of the mouth is uncommon. We reported a case of an 85-year-old man who was diagnosed with stage IV BSCC in the gingiva. An excision of partial resection mandible was performed and a functional elective neck dissection was carried out. The patientʼs recovery was uneventful until contralateral local regional lymph node metastasis was revealed by PET-CT.

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Prognoses of Oral Basaloid Squamous Cell Carcinoma and Squamous Cell Carcinoma

Cited by 45 publications

References 20 publications

Basaloid Squamous Cell Carcinoma of the Palate: Case Report

Basaloid Squamous Cell Carcinoma of the Palate: Case Report

p53 and p16 expression in oral cavity squamous cell and basaloid squamous cell carcinoma

Basaloid Squamous Cell Carcinoma of Gingiva: a New Case Report with Immunohistochemical Study

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