Progestogens and brain: An update

Pluchino, Nicola; Cubeddu, Alessandra; Giannini, Andrea; Merlini, Sara; Cela, Vito; Angioni, Stefano; Genazzani, Andrea Riccardo

doi:10.1016/j.maturitas.2008.11.023

Cited by 57 publications

(52 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Not all progestins can be converted into the GABA A receptor-active metabolites (Pluchino et al, 2009). Thus, not all hormonal contraceptives may have the same slight sedating effect that we alluded to in the main text.…”

Section: B Further Details On Hormonal Contraceptivesmentioning

confidence: 99%

Sex Hormones and Competitive Bidding

Schipper

2012

SSRN Journal

View full text Add to dashboard Cite

We correlate competitive bidding and profits in symmetric independent private value first-price auctions with salivary testosterone, estradiol, progesterone, and cortisol in more than 200 subjects. Bids are significantly positively correlated and profits are significantly negatively correlated with basal salivary progesterone but only for females who do not use hormonal contraceptives. Surprisingly, we have null findings for basal testosterone, estradiol, and cortisol for both males and females. We show that our finding for progesterone is not mediated by risk aversion or bidding mistakes. No hormone responds to total profits in the auctions except for a small positive response of the stress hormone cortisol in males.

show abstract

Section: B Further Details On Hormonal Contraceptivesmentioning

confidence: 99%

Sex Hormones and Competitive Bidding

Schipper

2012

SSRN Journal

View full text Add to dashboard Cite

show abstract

“…In animal studies, different patterns of changes in cognitive performance are reported when rodents are treated with each steroid alone or co-administered, and the effects are dependent on the age, dosing regimen, and task characteristics (for reviews, see Rupprecht, 2003;Daniel, 2006;Pluchino et al, 2009). Progesterone is reported to enhance cognitive performance, independent of estrogen, in young adult rodents (Frye and Lacey, 2000) and to enhance performance of aged mice on tasks mediated by the prefrontal cortex and the hippocampus but not on those medicated primarily by the amygdala, striatum and the cerebellum (Frye and Walf, 2008).…”

Section: Ovarian Hormones and Human Sensorimotor Gating V Kumari Et Almentioning

confidence: 99%

Evidence for a Role of Progesterone in Menstrual Cycle-Related Variability in Prepulse Inhibition in Healthy Young Women

Kumari

Konstantinou

Papadopoulos

et al. 2009

Neuropsychopharmacol

View full text Add to dashboard Cite

Prepulse inhibition (PPI) of the startle response is sensitive to sex, with healthy young women showing less PPI compared with age-matched men, and varies according to the menstrual cycle phase in women. Relatively less is known regarding sex and hormonal influences in prepulse facilitation (PPF). Menstrual phase-related variability in PPI is suggested to be mediated by fluctuating estrogen level, based on the observations of more PPI in women during the follicular, relative to the luteal, phase. No study has directly assessed the relationship between fluctuating hormones and PPI or PPF levels over the human ovarian cycle. To examine the roles of circulating ovarian hormones in PPI and PPF, 16 non-smoking regularly menstruating healthy women were tested during both the follicular and luteal phases on PPI and PPF and provided saliva samples for measurement of 17b-estradiol (estrogen), progesterone and testosterone. The results showed higher levels of 17b-estradiol and progesterone during the luteal, relative to the follicular, phase; and more PPI during the follicular phase and more PPF during the luteal phase with comparable startle amplitude and habituation during the two phases. A larger increase in progesterone was associated with a smaller decrease in PPI from the follicular to the luteal phase. No significant associations were found between changes in PPI/PPF and estrogen levels. The findings confirm lower PPI during the luteal, compared with the follicular, phase and suggest a role for progesterone, more specifically an antipsychotic-like PPI-restoration action of progesterone, during the luteal phase in PPI of young women.

show abstract

“…The action of progesterone on the brain, however, is manifold and complicated, which is indicated by the large number of brain regions that have progesterone receptors and by the fact that progesterone exerts genomic and non-genomic actions (2).…”

Section: Introductionmentioning

confidence: 99%

Progesterone, progestins and psychosomatic health of women

Bitzer

2010

Hormone Molecular Biology and Clinical Investigation

View full text Add to dashboard Cite

Psychosomatics as a medical perspective and discipline focuses on the interaction of physical and mental health in the specific life situation of a patient, taking into account the physical and emotional well-being, role functioning, satisfaction with the partner and family relationship, as well as sexual function and satisfaction. There are two important effects of progesterone on the combined physical, mental and sexual well-being of the climacteric patient. The first is the antiestrogenic effect of progesterone on the peripheral physical level which not only protects the endometrium against overstimulation but also reduces individual suffering from heavy bleeding, breast tension, bloating and general discomfort. The second effect is due to the complex action of progesterone in the brain. Studies using different progestins in different dosages and in different regimens show contradictory results. Some studies demonstrate an increase in depressed mood and reduced well-being while using synthetic progestins. Other studies, however, indicate an anxiolytic and sometimes antidepressant effect of progesterone and progesterone-like progestins with an improvement of emotional well-being and quality of life. In the individual patient, the positive or negative emotional and mental state can be conditioned by various pathways of progesterone and progestins. The antiestrogenic effect can attenuate the psychotropic effect of estradiol (E2) on the brain, thus reducing emotional well-being. Progesterone interacting with many brain areas can have a mood stabilizing and anxiolytic effect through the action on the GABA receptor. This effect seems to be strongest when using natural progesterone and the effect varies considerably among different progestins and different dosages due to metabolic pathways involving the production of allopregnanolone or other metabolites. In conclusion, the positive anxiolytic and sedative effects of progesterone on the central nervous system depend on the type of progestogen, the dosage, the timing of application, the combination with estrogen, etc. Progesterone and progestins have important potential to maintain or improve the psychosomatic health of women. Their use must, however, be tailored to specific symptom clusters and to the individual's pre-existing psychosomatic health status.

show abstract

Progestogens and brain: An update

Cited by 57 publications

References 82 publications

Sex Hormones and Competitive Bidding

Sex Hormones and Competitive Bidding

Evidence for a Role of Progesterone in Menstrual Cycle-Related Variability in Prepulse Inhibition in Healthy Young Women

Progesterone, progestins and psychosomatic health of women

Contact Info

Product

Resources

About