Progestogen Hypersensitivity

Li, Rung‐chi; Buchheit, Kathleen M.; Bernstein, Jonathan A.

doi:10.1007/s11882-018-0758-x

Cited by 15 publications

(10 citation statements)

References 40 publications

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“…Progesterone dermatitis (PD) is a skin disease due to progesterone toxicity, for example during the menstrual cycle [ 49 ]. Both PD and MHD develop in response to an endocrine disbalance or an external toxic stimulus, which explains their association in Figure 2 .…”

Section: Resultsmentioning

confidence: 99%

Autoimmune Disease Classification Based on PubMed Text Mining

Samuels

Malov

Saha

et al. 2022

JCM

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Autoimmune diseases (AIDs) are often co-associated, and about 25% of patients with one AID tend to develop other comorbid AIDs. Here, we employ the power of datamining to predict the comorbidity of AIDs based on their normalized co-citation in PubMed. First, we validate our technique in a test dataset using earlier-reported comorbidities of seven knowns AIDs. Notably, the prediction correlates well with comorbidity (R = 0.91) and validates our methodology. Then, we predict the association of 100 AIDs and classify them using principal component analysis. Our results are helpful in classifying AIDs into one of the following systems: (1) gastrointestinal, (2) neuronal, (3) eye, (4) cutaneous, (5) musculoskeletal, (6) kidneys and lungs, (7) cardiovascular, (8) hematopoietic, (9) endocrine, and (10) multiple. Our classification agrees with experimentally based taxonomy and ranks AID according to affected systems and gender. Some AIDs are unclassified and do not associate well with other AIDs. Interestingly, Alzheimer’s disease correlates well with other AIDs such as multiple sclerosis. Finally, our results generate a network classification of autoimmune diseases based on PubMed text mining and help map this medical universe. Our results are expected to assist healthcare workers in diagnosing comorbidity in patients with an autoimmune disease, and to help researchers in identifying common genetic, environmental, and autoimmune mechanisms.

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Section: Resultsmentioning

confidence: 99%

Autoimmune Disease Classification Based on PubMed Text Mining

Samuels

Malov

Saha

et al. 2022

JCM

View full text Add to dashboard Cite

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“…One hundred twelve articles were found to include a case report meeting our inclusion criteria 3–114 . Within these articles, 132 unique cases of AIPD were identified.…”

Section: Resultsmentioning

confidence: 99%

Autoimmune Progesterone Dermatitis: A Systematic Review

et al. 2021

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Autoimmune progesterone dermatitis (AIPD) is a cyclical, cutaneous reaction to endogenous progesterone that occurs throughout the menstrual cycle. The cutaneous manifestations of AIPD vary greatly from patient to patient, ranging anywhere from urticaria to erythema multiforme to anaphylaxis. As such, recognition, diagnosis, and management of this condition are difficult for clinicians. In the present article, we conducted a systematic review of 112 articles and 132 individual cases to summarize the clinical features and presentation of AIPD while also summarizing the successes and failures of different treatment plans. Despite the great variety in clinical presentations, it is clear from the data that ovulation-suppressing medical therapies and surgery have the greatest success in treating AIPD, whereas more commonly used therapies such as antihistamines and systemic corticosteroids frequently fail in providing any relief. Further research is necessary to determine the exact pathogenesis of AIPD and allow for more targeted treatment.

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“…Diagnosis is based on cutaneous eruptions related to increase in progesterone levels and may be confirmed by intracutaneous progesterone testing or progesterone-specific IgE serum. Other available but less useful diagnostic methods include: intramuscular progesterone injection, oral progesterone intake, patch testing (with a low negative predictive value), in vitro leukocyte histamine release assay and interferon-gamma-release assay (6). Clinical presentation is highly variable and includes all urticaria manifestations with or without angioedema, vesiculobullous, eczematous or purpuric lesions, as well as cutaneous eruptions resembling Stevens-Johnson syndrome, erythema multiforme or fixed drug eruptions (4); asthma and anaphylaxis may rarely accompany the symptoms (7).…”

Section: Discussionmentioning

confidence: 99%

Progesterone hypersensitivity: Case report with favorable evolution

et al. 2018

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Progesterone hypersensitivity or autoimmune progesterone dermatitis is characterized by heterogeneous skin eruptions that cyclically aggravate during the second half of the menstrual cycle, corresponding to a rise in the progesterone level. Clinical presentation is highly variable and includes all urticaria manifestations with or without angioedema, vesiculobullous, eczematous, purpuric or target-like lesions on the skin and mucous membrane. Both endogenous progesterone as well as exogenous progestogens may represent an initial trigger. We report a case of progesterone hypersensitivity in a 27-year old woman with favorable evolution only on topical therapy, the positive clinical outcome being maintained during a subsequent pregnancy and postpartum period.

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Progestogen Hypersensitivity

Cited by 15 publications

References 40 publications

Autoimmune Disease Classification Based on PubMed Text Mining

Autoimmune Disease Classification Based on PubMed Text Mining

Autoimmune Progesterone Dermatitis: A Systematic Review

Progesterone hypersensitivity: Case report with favorable evolution

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