Progestins to control feline reproduction

Romagnoli, Stefano

doi:10.1177/1098612x15594987

Cited by 27 publications

(29 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, the administration of oral contraceptive to domestic animals has been associated with an increased risk in developing tumours, including mammary tumours [62]. Some authors support that over the past forty years, cats have received an excessive dosage of hormones to control reproductive cycles and believe that the administration of lower doses of such compounds and the option for more recent molecules would be potentially safer [63].…”

Section: Discussionmentioning

confidence: 99%

Gene expression association study in feline mammary carcinomas

et al. 2019

View full text Add to dashboard Cite

Works on cancer-related genes expression using feline mammary carcinomas (FMCs) are scarce but crucial, not only to validate these tumours as models for human breast cancer studies but also to improve small animal practice. Here, the expression of the cancer-related genes TP53 , CCND1 , FUS , YBX1 , PTBP1 , c-MYC and PKM2 was evaluated by real-time RT-qPCR, in a population of FMCs clinically characterized and compared with the disease-free tissue of the same individual. In most of the FMCs analysed, RNA quantification revealed normal expression levels for TP53 , c-MYC , YBX1 and FUS , but overexpression in the genes CCND1 , PTBP1 and PKM2 . The expression levels of these cancer-related genes are strongly correlated with each other, with exception of c-MYC and PKM2 genes. The integration of clinicopathological data with the transcriptional levels revealed several associations. The oral contraceptive administration showed to be positively related with the TP53 , YBX1 , CCND1 , FUS and PTBP1 RNA levels. Positive associations were found between tumour size and YBX1 RNA, and lymph node metastasis with c-MYC RNA levels. This work allowed to verify that many of these cancer-related genes are associated but may also, indirectly, influence other genes, creating a complex molecular cancer network that in the future can provide new cancer biomarkers.

show abstract

Section: Discussionmentioning

confidence: 99%

Gene expression association study in feline mammary carcinomas

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The progestogen dosage was unknown for these cats, although overdosing of these compounds was common in cats throughout the last century and until the beginning of this century. 5 The cats that were treated with surgery and/or chemotherapy went on to have a median survival time of 451 days. 6 Separately, a case series reported mammary adenocarcinoma in three male cats that had been treated with depot injections of MPA for controlling aggression.…”

Section: Progestogensmentioning

confidence: 99%

Reversible control of reproduction in tom cats: medical options for manipulating libido and fertility

Ferré-Dolcet¹,

Romagnoli

2023

Journal of Feline Medicine and Surgery

Self Cite

View full text Add to dashboard Cite

Background: There has been a growing interest in alternatives to surgery for controlling reproduction in tom cats, and the resultant medical options add to a practitioner’s toolbox when handling these cases in clinical practice. It is important, however, that when suggesting these drugs, veterinarians have a good understanding of their mode of action, and their correct use and dosage. Clinical relevance: Breeders increasingly wish to be able to switch on/off the reproductive ability of their tom cats in a controlled manner. In addition, in small animal medicine, there has been concern from some academics, and a growing number of pet cat owners, about potential long-term effects of surgical sterilisation. Further, for some cats surgical castration may not be possible due to health conditions that mean anaesthesia is unsafe. In all of these scenarios, medical alternatives to surgery can prove useful. Equipment and technical skills: No special equipment or technical skills are required. A good knowledge of the medical alternatives to surgical sterilisation for controlling reproduction in a tom, and making sure the patient is a suitable candidate, are, however, important for ensuring the cat’s health during and after treatment and the owner’s satisfaction. Audience: This review is aimed principally (but not exclusively) at veterinary practitioners working with cat breeders who seek a temporary arrest in their tom cat’s reproduction. It may also help practitioners with clients who would like an alternative to surgery or with cats where anaesthesia for surgical castration is not possible. Evidence base: Advances in reproductive feline medicine have resulted in improved knowledge of medical contraception. This review draws on scientific evidence-based papers that report on the mode of action, length of efficacy and potential side effects of different methods of medical contraception, as well as the authors’ own clinical experience.

show abstract

“…6,7,10 MA becomes dangerous when the above-mentioned 0.625 mg/kg dose is administered at a much higher frequency, such as daily or every other day for several weeks, or weekly for months. Unfortunately, such protocols have previously been repeatedly used long term for prolonged oestrus postponement, 1 as well as for reproductive reasons, and many cats (both intact and spayed queens, as well as tom cats) have developed mammary gland lesions (mammary hyperplasia, as well as benign and malignant tumours), skin lesions (cutaneous xanthomatosis), blindness (due to hyperlipidaemia causing opacity of the anterior chamber) 13–20 and uterine lesions (cystic endometrial hyperplasia [CEH], pyometra, adenomyosis), 21–30 as well as more severe and longer lasting endocrine side effects (diabetes and adrenocortical suppression). 31–34…”

Section: Progestogensmentioning

confidence: 99%

“…Contrary to the published misinformation, MA is a safe drug, assuming correct dosing (~0.009 mg/kg q24h) and careful patient choice (see later). 1 A formulation of MA is commercially available for cat-only use in…”

Section: Progestogensmentioning

confidence: 99%

“…Unfortunately, progestogens have been misused for a long time based on an inadequate assessment of the evidence published within the veterinary literature. 1 This led to a widespread misconception about progestogens, which are, in fact, safe compounds provided that drug dosing and patient selection are based on scientific evidence. More recently, from the turn of the century, a few interesting alternative drugs for reversible control of reproduction in queens have also emerged, such as long-acting gonadotropin-releasing hormone (GnRH) agonists and melatonin.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Reversible Control of Reproduction In Queens: Mastering the use of reproductive drugs to manipulate cyclicity

Romagnoli

Ferré-Dolcet²

2022

Journal of Feline Medicine and Surgery

Self Cite

View full text Add to dashboard Cite

Background: The literature is full of papers reporting side effects of progestogens in cats; however, they are, in fact, safe drugs, as discussed in this article. Gonadotropin-releasing hormone (GnRH) agonists and melatonin are additionally a practical solution for controlling cyclicity in queens, but they also have some contraindications and need to be used carefully. Clinical relevance: Mastering the use of reproductive drugs allows feline practitioners to handle many more clinical situations than can be solved using surgery. It is not necessary to be a specialist in reproduction to be able to halt cyclicity in a valuable breeding queen using hormones. Equipment and technical skills: A sound knowledge of appropriate dosages and criteria for patient selection for all reproductive drugs currently used in feline reproduction is the best guarantee of owner satisfaction and of ensuring the queen’s health. Availability of a serum progesterone assay, either in-house or via an external laboratory, is also important, in order to confirm a queen is at an appropriate stage of the reproductive cycle for treatment. Audience: This article is aimed principally (but not exclusively) at veterinarians working with cat breeders and whose clientele is increasingly interested in alternative methods of controlling reproduction in pet queens. Surgery is no longer the only choice, and practitioners who manage to keep abreast of new developments will be able to address clients’ needs in a modern, professional way. Evidence base: This review draws on a vast body of scientific evidence-based literature. Previously, personal (and sometimes misinformed) opinions, such as the proposed dangerous side effects of progestogens, have been perpetuated in the scientific literature. The papers cited in this review have therefore been carefully scrutinised to distinguish reliable information based on controlled studies from non-evidence-based information.

show abstract

Progestins to control feline reproduction

Cited by 27 publications

References 55 publications

Gene expression association study in feline mammary carcinomas

Gene expression association study in feline mammary carcinomas

Reversible control of reproduction in tom cats: medical options for manipulating libido and fertility

Reversible Control of Reproduction In Queens: Mastering the use of reproductive drugs to manipulate cyclicity

Contact Info

Product

Resources

About