Progestins inhibit fsh-stimulated steroidogenesis in cultured rat granulosa cells

Schreiber, James R.; Nakamura, Kevin; Erickson, Gregory F.

doi:10.1016/0303-7207(80)90019-2

Cited by 79 publications

(24 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The low serum E2 and P4 levels observed in the present study indicate impaired follicular development, maturation, rupture, ovulation and luteal activity, which were also observed in previous studies [2,11,19,26,33]. Exogenous progestin can directly inhibit steroidogenesis [33]. LNG is a synthetic progestin which has strong progesterone-like and anti-ovulatory activities, but it lacks estrogen-like activity [15].…”

Section: Discussionsupporting

confidence: 86%

“…Follicular growth is demonstrated by serum E2 patterns, while luteal function is measured by serum P4 levels [11]. The low serum E2 and P4 levels observed in the present study indicate impaired follicular development, maturation, rupture, ovulation and luteal activity, which were also observed in previous studies [2,11,19,26,33]. Exogenous progestin can directly inhibit steroidogenesis [33].…”

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

Effects of Levonorgestrel on Reproductive Hormone Levels and Their Receptor Expression in Mongolian Gerbils (Meriones unguiculatus)

Shi

2011

Exp. Anim.

View full text Add to dashboard Cite

Abstract:The effects of levonorgestrel (LNG) on serum levels of reproductive hormones and their receptor mRNA expression in the ovary and uterus of Mongolian gerbils were examined. The results show that serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) increased, whereas serum estradiol (E2) and progesterone (P4) decreased profoundly after LNG treatment. LNG down-regulated the mRNA expression of folliclestimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), estrogen receptor (ER) β and progesterone receptor (PR) in the ovary, and ERα and PR in the uterus of Mongolian gerbils. The down-regulated effects were time-dependent and dose-dependent. LNG had no obvious effects on ERα mRNA expression in the ovary. The findings suggest that LNG impairs reproductive hormone receptor expression at the molecular level in Mongolian gerbils. Also, the two ER subtypes may play different roles in the ovary, and ERβ may not be the predominant ER subtype in the uterus of Mongolian gerbils. The ovary and uterus may be the important sites of action of LNG through its direct progesterone-like effects in Mongolian gerbils.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 82%

Effects of Levonorgestrel on Reproductive Hormone Levels and Their Receptor Expression in Mongolian Gerbils (Meriones unguiculatus)

Shi

2011

Exp. Anim.

View full text Add to dashboard Cite

show abstract

“…Due to this glucocorticoid activity progestin treatment results in suppression of plasma cortisol concentrations in humans [44,45], dogs [46][47][48] and cats [49,50] and reduces the plasma concentrations of sex steroids in postmenopausal breast cancer patients [51][52][53]. In vitro progestins inhibit the biosynthesis of DHP and estradiol in rat granulosa cells [54,55] and of estradiol in breast cancer cell lines [56]. The beneficial effects on tumour progression of medroxyprogesterone acetate show also a better correlation with androgen receptor content than progesterone receptor content of mammary carcinomas [42].…”

Section: Discussionmentioning

confidence: 99%

Mammary steroid metabolizing enzymes in relation to hyperplasia and tumorigenesis in the dog

Marinelli

Gabai

Wolfswinkel

et al. 2004

The Journal of Steroid Biochemistry and Molecular Biology

View full text Add to dashboard Cite

“…All these 92 women underwent sonohysterosalpingography and they showed bilateral tubal patency and no endometrial cavity abnormalities. 11 The IUI treatment resulted in 44 women conceived (age: 29.8 ± 3.8, mean ± SD, range [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38]. In total these 44 women had undergone a total of 117 treatment cycles (ie, 44 conceptional and 73 non-conceptional).…”

Section: Methodsmentioning

confidence: 99%

“…[22][23][24] Also, progesterone administered before pregnant mares' serum (PMS) injection appears to inhibit early follicular growth and causes atresia, suppressing the proliferation of granulosa cells, and consequently suppresses superovulation induced by PMS and human chorionic gonadotropin (HCG) in hypophysectomized rats. 25 Taken together, results from the present study in combination with results from animal studies suggest that progesterone exerts a local paracrine effect on ovaries that reduces the optimal developmental capacity of subsequent follicles of that ovary during the following cycle.…”

mentioning

confidence: 99%

Do Hormonal Characteristics of the Luteal Phase Affect the Conception Rate of Women Undergoing IUI Treatment in the Following Menstrual Cycle?

Fukuda¹,

Fukuda²,

Byskov³

et al. 2011

Reproductive Biology Insights

View full text Add to dashboard Cite

Objective: The present study was performed to evaluate whether the hormone profiles of the mid-luteal phase impact on the chances of conceiving during the following menstrual cycle in connection with intrauterine insemination (IUI) treatment. Design: Observational clinical study. Setting: Infertility clinic. Patient(s): 92 women underwent a total of 288 IUI treatment cycles, without use of exogenous hormones. Intervention(s):The mid-luteal hormone profiles including levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, oestradiol, progesterone, androstenedione and testosterone, were measured in the preceding cycle of IUI treatment. Main outcome measure(s):The mid-luteal hormone profiles were correlated to whether the women conceived in the following natural menstrual cycle in which IUI treatment was performed and to whether ovulation occurred on the same ovary in two consecutive cycles (ipsilateral ovulation) or jumped from one ovary to the other (contralateral ovulation). Result(s): When ovulation occurred from the same ovary in two consecutive cycles mid-luteal levels of progesterone of the preceeding cycle were significantly lower in conceptional than non-conceptional cycles. No significant differences of LH, FSH, estradiol, androstendione and testosterone were observed when correlating the different parameters. Conclusion(s):Lower mid-luteal progesterone levels seem to enhance chances of conception when ovulation occurs in the same ovary for two consecutive cycles.

show abstract

Progestins inhibit fsh-stimulated steroidogenesis in cultured rat granulosa cells

Cited by 79 publications

References 18 publications

Effects of Levonorgestrel on Reproductive Hormone Levels and Their Receptor Expression in Mongolian Gerbils (Meriones unguiculatus)

Effects of Levonorgestrel on Reproductive Hormone Levels and Their Receptor Expression in Mongolian Gerbils (Meriones unguiculatus)

Mammary steroid metabolizing enzymes in relation to hyperplasia and tumorigenesis in the dog

Do Hormonal Characteristics of the Luteal Phase Affect the Conception Rate of Women Undergoing IUI Treatment in the Following Menstrual Cycle?

Contact Info

Product

Resources

About