Progestins inhibit FSH-stimulated granulosa estrogen production at a post-cAMP site

Do Hormonal Characteristics of the Luteal Phase Affect the Conception Rate of Women Undergoing IUI Treatment in the Following Menstrual Cycle?

“…All these 92 women underwent sonohysterosalpingography and they showed bilateral tubal patency and no endometrial cavity abnormalities. 11 The IUI treatment resulted in 44 women conceived (age: 29.8 ± 3.8, mean ± SD, range [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38]. In total these 44 women had undergone a total of 117 treatment cycles (ie, 44 conceptional and 73 non-conceptional).…”

“…In total these 44 women had undergone a total of 117 treatment cycles (ie, 44 conceptional and 73 non-conceptional). The remaining 48 women who did not conceive underwent a total of 171 treatment cycles (age 30.3 ± 3.8 years, range [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38]. The causes of infertility among the 44 women who conceived were male factor, 34 and unknown, 10.…”

“…[22][23][24] Also, progesterone administered before pregnant mares' serum (PMS) injection appears to inhibit early follicular growth and causes atresia, suppressing the proliferation of granulosa cells, and consequently suppresses superovulation induced by PMS and human chorionic gonadotropin (HCG) in hypophysectomized rats. 25 Taken together, results from the present study in combination with results from animal studies suggest that progesterone exerts a local paracrine effect on ovaries that reduces the optimal developmental capacity of subsequent follicles of that ovary during the following cycle.…”

Effects of exogenous steroid hormones on the dominant follicle maintained by a Norgestomet implant in heifers

“…Jacob and Smith (1990) reported the presence of progestin binding sites in the ovary of the cow. Progestins have been shown to inhibit FSH induction of aromatase activity in the rat (Schreiber et al 1981) and the goat (Kharbanda et al 1990 (Hausler and Malven 1976;Beck and Convey 1971) and prepubertal heifers (Schillo et al 1982). Evidence for a direct effect of E2 on the dominant follicle has been provided by Hutz et al (1990 (Farookhi 1980).…”

Changes in ovarian follicular dynamics and luteinizing hormone profiles following different progestagen treatments in cattle

“…Rexroad and Casida (1977) found that progesterone hastened follicular growth when it was injected into the ovary of sheep and that the effect was independent of ovarian estradiol l7B content. Progestin binding sites have been reported in the ovaries of the cow (Jacobs and Smith 1990) and have been isolated in the granulosa cells of rat (Schreiber et al 1981). In addition,…”