Progestin Permeation through Polymer Membranes I: Diffusion Studies on Plasma-Soaked Membranes

Zentner, Gaylen M.; Cardinal, John R.; Kim, Sung Wan

doi:10.1002/jps.2600671003

Cited by 36 publications

(6 citation statements)

References 26 publications

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“…There is good agreement between the two curves, as seen in Figure 3, with the treated disks providing a partition coefficient (33.7 AE 1.7) well within the error of the untreated disks. These findings are in agreement with the data of Zentner et al 11 who showed that the partition of progesterone into a silicone polymer occurred independently of preincubation of the polymer with plasma (during which time adsorption of plasma components, including lipids, to the polymer was expected). Therefore, we conclude that when studying more complex model digest systems, although it is necessary to pre-equilibrate the disks in the lipid system without drug, the presence of fatty acid in the polymer does not substantially affect the subsequent partitioning behavior.…”

Section: Partitioning Of Lipid Components (Nondrug) Into Polymer Diskssupporting

confidence: 93%

Using the Polymer Partitioning Method to Probe the Thermodynamic Activity of Poorly Water‐soluble Drugs Solubilized in Model Lipid Digestion Products

Boyd

Porter

Charman

2003

Journal of Pharmaceutical Sciences

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Section: Partitioning Of Lipid Components (Nondrug) Into Polymer Diskssupporting

confidence: 93%

Using the Polymer Partitioning Method to Probe the Thermodynamic Activity of Poorly Water‐soluble Drugs Solubilized in Model Lipid Digestion Products

Boyd

Porter

Charman

2003

Journal of Pharmaceutical Sciences

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“…For example, diffusivity of the antimicrobial potassium sorbate from whey protein polymer films at 25°C was found to be ∼5 × 10 −10 cm 2 s −1 . Diffusivities of a hydrophobic drug, progesterone, from polyether based polyurethane films were near 5 × 10 −10 cm 2 s −1 at 25°C . Diffusivity of the antibiotic tetracycline in poly(styrene‐ b ‐isobutylene‐ b ‐styrene) (SIBS) at 37°C was predicted by molecular dynamics simulations to be 3 × 10 −11 cm 2 s −1 .…”

Section: Resultsmentioning

confidence: 99%

“…Leaching experiments performed into physiologically representative extraction media validated the model predictions under a range of conditions, and were compared to a conservative screening threshold of toxicological concern (TTC) value for QB. We anticipate that this approach can be applied to improve risk assessments for a wide range of medical device polymers that contain color additives, particularly in cases where color additives are poorly soluble in the matrix, more rigid polymers through which diffusants move more slowly, and additives that lack sufficient toxicity data to derive acceptable levels of exposure …”

Section: Introductionmentioning

confidence: 99%

“…We anticipate that this approach can be applied to improve risk assessments for a wide range of medical device polymers that contain color additives, particularly in cases where color additives are poorly soluble in the matrix, 18 more rigid polymers through which diffusants move more slowly, and additives that lack sufficient toxicity data to derive acceptable levels of exposure. 19…”

Section: Introductionmentioning

confidence: 99%

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Improving risk assessment of color additives in medical device polymers

Chandrasekar

Janes²,

Forrey

et al. 2017

J Biomed Mater Res

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Many polymeric medical device materials contain color additives which could lead to adverse health effects. The potential health risk of color additives may be assessed by comparing the amount of color additive released over time to levels deemed to be safe based on available toxicity data. We propose a conservative model for exposure that requires only the diffusion coefficient of the additive in the polymer matrix, D, to be specified. The model is applied here using a model polymer (poly(ether-block-amide), PEBAX 2533) and color additive (quinizarin blue) system. Sorption experiments performed in an aqueous dispersion of quinizarin blue (QB) into neat PEBAX yielded a diffusivity D 5 4.8 3 10 210 cm 2 s 21 , and solubility S 5 0.32 wt %. On the basis of these measurements, we validated the model by comparing predictions to the leaching profile of QB from a PEBAX matrix into physiologically representative media. Toxicity data are not available to estimate a safe level of exposure to QB, as a result, we used a Threshold of Toxicological Concern (TTC) value for QB of 90 mg/adult/day. Because only 30% of the QB is released in the first day of leaching for our film thickness and calculated D, we demonstrate that a device may contain significantly more color additive than the TTC value without giving rise to a toxicological concern. The findings suggest that an initial screening-level risk assessment of color additives and other potentially toxic compounds found in device polymers can be improved.

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“…It has been reported that the permeation of such solute as KCl in chitosan is likely to be described by pore diffusion mechanism [32][33][34] . The solute is presumed to diffuse through microchannels with the membrane structure.…”

Section: Permeabilitymentioning

confidence: 99%

Chitosan Membrane: Tool for Chromium (III) Recovery from Aqueous Solutions

Pietrelli

Liu

2004

Annali di Chimica

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In this study four kinds of Chitosan membranes were prepared. The permeability of the membranes was then investigated by permeation of K+ in these membranes. The performances of the prepared membranes for recovery of chromium (III) from aqueous solution were evaluated. The effects of operation conditions on permeation characteristics were determined, and permeation mechanism was discussed. The stability of the membranes was also studied.

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Progestin Permeation through Polymer Membranes I: Diffusion Studies on Plasma-Soaked Membranes

Cited by 36 publications

References 26 publications

Using the Polymer Partitioning Method to Probe the Thermodynamic Activity of Poorly Water‐soluble Drugs Solubilized in Model Lipid Digestion Products

Using the Polymer Partitioning Method to Probe the Thermodynamic Activity of Poorly Water‐soluble Drugs Solubilized in Model Lipid Digestion Products

Improving risk assessment of color additives in medical device polymers

Chitosan Membrane: Tool for Chromium (III) Recovery from Aqueous Solutions

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