Progestin-only pills for contraception

Progestin-only contraception compared with extended combined oral contraceptive in women with migraine without aura: a retrospective pilot study

“…more elevated in CHC users compared to non-users, while interestingly no increased risk was found for POP users [12,13]. Surprisingly, although progestins have a lower cardiovascular risk compared to CHC, only a few studies have evaluated these compounds in this high-risk population of patients with MO [21][22][23][24] and the use of progestins has not been consistent over time, probably due to the fact that these compounds cause more adverse effects (such as weight gain, mastalgia and irregular menstrual bleeding) than CHCs and that they might be less tolerated by the patients [25]. Over the last two years, renewed interest has been focused on the use of progestins (desogestrel-only pill) in migrainous women.…”

Drospirenone-only oral contraceptive: results from a multicenter noncomparative trial of efficacy, safety and tolerability

“…[5,6,7,8] Desogestrel 75µg was an improvement over traditional POPs with a more generous missed pill window (12 hours), but Desogestrel 75µg's bleeding profile remains a significant barrier to more widespread use. [9] A novel Drospirenone (DRSP) only pill, was developed to improve compliance and side effects.…”

Vascular dysfunction as a cause of endometrial bleeding

“…There may be differences between the occurrence of S/B in women based on the type of progestin administered, but the differences are slight and of no clinical significance [57,59]. Progestin-only oral contraceptives (POP) have a high incidence of unscheduled bleeding [62,63], but a reasonable contraceptive efficacy.…”