Progestin, estrogen and androgen G-protein coupled receptors in fish gonads

Thomas, Peter; Dressing, Gwen E.; Pang, Yefei; Berg, André; Tubbs, Christopher W.; Benninghoff, Abby D.; Doughty, Kelly

doi:10.1016/j.steroids.2005.09.015

Cited by 112 publications

(63 citation statements)

References 35 publications

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“…The present results suggest that extranuclear actions on neurons can be inhibited by conventional nuclear steroid receptor antagonists, indicating a similarity of ligand-binding domains between nuclear and extranuclear sites of steroid action (for estrogens, see Razandi et al, 1999). Notably, the specificity of rapid androgen actions (11kT vs T vs DHT) implies that neuronal androgen binding sites are markedly "tuned" in midshipman, consistent with the specificity of both nuclear and membrane androgen receptors observed in other teleosts (Olsson et al, 2005;Thomas et al, 2006).…”

Section: Mechanisms Of Rapid Steroid Actionsupporting

confidence: 53%

“…The principle role of 11-ketotestosterone in regulating the expression of type I male-like secondary sex traits (Brantley et al, 1993;Borg, 1994) and exclusive male parental care (Magee et al, 2006;Rodgers et al, 2006) suggests a key innovation in the widespread evolution of ARTs among teleosts (Mank and Avise, 2006). Recent discoveries of a teleost androgen receptor specifically activated by 11kT (Olsson et al, 2005) and an 11kT-responsive membrane androgen receptor (Thomas et al, 2006) may provide clues about the molecular origins and refinement of 11kT-dependent mechanisms.…”

Section: Type I Territorial Males: Novel Neuroendocrine Phenotypementioning

confidence: 99%

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Plasticity in Brain Sexuality Is Revealed by the Rapid Actions of Steroid Hormones

Remage‐Healey¹,

Bass²

2007

J. Neurosci.

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Divergent steroid hormone profiles can shape the development of male versus female neural phenotypes, but whether they also determine differences in the short-term, neurophysiological patterning of behavior is unknown. We now show that steroid hormone-specific modulation of a vocal pattern generator (VPG) diverges between reproductive morphs in a teleost fish. Only type I male midshipman acoustically court females, whereas type II males steal fertilizations from type I males and, like females, generate only agonistic calls. The androgen 11-ketotestosterone (11kT), but not testosterone (T), rapidly (within 5 min) increases type I VPG output. As now shown, T, but not 11kT, rapidly increases VPG output in type II males and females, consistent with the predominant circulating androgen in type II males and females (T) versus type Is (11kT). Receptor and enzyme antagonists reveal an unexpected divergence in androgen-versus estrogen-dependent mechanisms in, respectively, type II males versus females. Cortisol, the main circulating glucocorticoid, also has divergent actions: suppressing versus increasing VPG output in, respectively, type II males and females versus type Is. In summary, rapid steroid action on VPG activity is uncoupled from gonadal phenotype (convergent between type II males and females), whereas the receptor-mediated mechanisms of androgen action are predicted by gonadal phenotype (both male morphs are sensitive to androgen receptor blockade, whereas females are not). A comparable mix of neuroendocrine traits may explain the widespread distribution of intrasexual behavioral phenotypes among teleosts and vertebrates in general. Moreover, the fundamental organization/activation principles that predict the steroid-dependent expression of "maleness" and "femaleness" may now include rapid steroid actions on the neurophysiological patterning of behavior.

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Section: Mechanisms Of Rapid Steroid Actionsupporting

confidence: 53%

Section: Type I Territorial Males: Novel Neuroendocrine Phenotypementioning

confidence: 99%

Plasticity in Brain Sexuality Is Revealed by the Rapid Actions of Steroid Hormones

Remage‐Healey¹,

Bass²

2007

J. Neurosci.

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“…Recent discoveries of an androgen receptor specifically activated by 11kT (Olsson et al, 2005) and an 11kT-responsive membrane androgen receptor (Thomas et al, 2006) lend support to the hypothesis that multiple types of androgen-binding sites occur in teleost brain. Our findings do not rule out the possibility, however, that a common binding site (e.g., membrane androgen receptor) is responsible for both the 11kT and T effects, and that the androgen sensitivity of this receptor is uniquely modified in, for example, type I vs. type II male midshipman.…”

Section: Androgen-dependent Plasticity Of Vocal Cpg Activitymentioning

confidence: 95%

Central pattern generators for social vocalization: Androgen-dependent neurophysiological mechanisms

Bass

Remage‐Healey

2008

Hormones and Behavior

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Historically, most studies of vertebrate central pattern generators (CPGs) have focused on mechanisms for locomotion and respiration. Here, we highlight new results for ectothermic vertebrates, namely teleost fish and amphibians, showing how androgenic steroids can influence the temporal patterning of CPGs for social vocalization. Investigations of vocalizing teleosts show how androgens can rapidly (within minutes) modulate the neurophysiological output of the vocal CPG (fictive vocalizations that mimic the temporal properties of natural vocalizations) inclusive of their divergent actions between species, as well as intraspecific differences between male reproductive morphs. Studies of anuran amphibians (frogs) demonstrate that long-term steroid treatments (wks) can masculinize the fictive vocalizations of females, inclusive of its sensitivity to rapid modulation by serotonin. Given the conserved organization of vocal control systems across vertebrate groups, the vocal CPGs of fish and amphibians provide tractable models for identifying androgen-dependent events that are fundamental to the mechanisms of vocal motor patterning. These basic mechanisms can also inform our understanding of the more complex CPGs for vocalization, and social behaviors in general, that have evolved among birds and mammals.

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“…In the case of estrogen and progesterone, specific GPCRs have been identified, namely GPR30 for estrogen (17,18) and mPR for progesterone (5), respectively.…”

Section: Introductionmentioning

confidence: 99%

Membrane androgen receptor activation in prostate and breast tumor cells: Molecular signaling and clinical impact

et al. 2008

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In recent years, membrane androgen receptors (mARs) have been identified in prostate and breast tumor cells, and their activation by specific mAR ligands was linked to the regulation of crucial cell responses, such as cell growth, motility, and apoptosis. Analysis of the molecular signals triggered by mAR in the presence of anti‐androgens has clearly differentiated mAR‐dependent biological actions from those induced by the activation of the classical intracellular androgen receptors (iARs). In this review, we summarize the specific cellular events attributed to mAR activation and the experimental results on distinct non‐genomic signaling cascades operating in various tumor cells independently of the iAR. Furthermore, we discuss the crucial role of actin cytoskeleton organization and signaling in mediating mAR responses. Finally, we assess the clinical impact of the reported mAR‐induced apoptotic regression of prostate cancer cells both in vitro and in vivo and discuss the potential role of mAR as a novel therapeutic target. © 2008 IUBMB IUBMB Life, 61(1): 56–61, 2009

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Progestin, estrogen and androgen G-protein coupled receptors in fish gonads

Cited by 112 publications

References 35 publications

Plasticity in Brain Sexuality Is Revealed by the Rapid Actions of Steroid Hormones

Plasticity in Brain Sexuality Is Revealed by the Rapid Actions of Steroid Hormones

Central pattern generators for social vocalization: Androgen-dependent neurophysiological mechanisms

Membrane androgen receptor activation in prostate and breast tumor cells: Molecular signaling and clinical impact

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