Progesterone resistance in endometriosis: origins, consequences and interventions

Abstract

Endometriosis is a common cause of pelvic pain and affects up to 10% of women of reproductive age.

Ovarian reserve after three-step laparoscopic surgery for endometriomas utilizing dienogest: a non-randomized prospective pilot study

“…Although some women showed decline in all these five molecules, the degree of decline and distributions of declined cytokines and chemokines were not homogenous among the subjects. These results may relate to the individual difference in response against dienogest, which may be hypothesized as progesterone-resistance in the pathogenesis of endometriosis [18]. On the other hand, we did not find correlation between the changes in these cytokines and chemokines in peritoneal fluids and the surgical findings at SLL or the changes in serum AMH levels.…”

Pathogenesis of deep endometriosis

“…It remains unclear whether endometriosis is composed of functional or basal endometrium. The latter might be suggested by the well-demonstrated P resistance (116)(117)(118)(119)(120)(121)(122)(123).…”

Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why

“…Progesterone resistance associated with endometriosis contributes to increased cell proliferation and survival (54) and elevated estrogen receptors (55). As progesterone plays a role in decreasing inflammation in the endometrium, the insensitivity to progesterone signaling results in a pro-inflammatory condition (108, 109). The consequences of this is far-reaching affecting estrogen driven mechanisms and differentiating capacity of the tissue.…”