Progesterone PLGA/mPEG-PLGA Hybrid Nanoparticle Sustained-Release System by Intramuscular Injection

Xie, Bin; Liu, Yang; Guo, Yuting; Zhang, Enbo; Pu, Chenguang; He, Huan; Yin, Tian; Tang, Xing

doi:10.1007/s11095-018-2357-x

Cited by 11 publications

(3 citation statements)

References 29 publications

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“…Polyesters such as poly(L-lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), poly-ε-caprolactone (PCL) and their copolymers synthesized from ring-opening polymerization (ROP) of cyclic lactone monomers have shown great promise in biomedical applications including controlled drug-delivery (microparticles, nanoparticles, or micelles) [1][2][3][4][5] due to their in vivo degradability and biocompatibility. 6,7 PLGA copolymers and poly (ethylene glycol) methyl ether-block-poly (lactic-co-glycolic acid) (mPEG-PLGA) copolymers constitute an important class of biologically relevant copolymers.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of methoxy-poly(ethylene glycol)-block-poly(l-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Green synthesis of methoxy-poly(ethylene glycol)-block-poly(l-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo

et al. 2021

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“…penicillin G procaine, methylprednisolone). Moreover, some drugs, including peptides and proteins, have been formulated as emulsions, suspensions, liposomes and even nanoparticles for IM injection, in order to achieve adequate pharmacokinetic profiles for each active ingredient (Hwang et al 2016;Xie et al 2018).…”

Section: Technological Factors That Modify the Im Absorption Of Drugsmentioning

confidence: 99%

Drug Transporters

Talevi¹,

Bellera²,

Pesce³

2018

ADME Processes in Pharmaceutical Sciences

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“…Lipid coating PLGA nanoparticles system (lipid nanoparticles, LNPs) has not only combined the advantages of polymer nanoparticles and liposomes but efficiently avoided the defects of them (Muller and Keck, 2004; Alavi et al, 2017). The dual advantages of the particles and vesicle make it an excellent oral drug carrier with high biocompatibility and sustained release (Xie et al, 2018). In this system, drugs can be efficiently encapsulated in the nanoparticles core and/or the lipid bilayers, resulted in increased drug load capability.…”

Section: Introductionmentioning

confidence: 99%

Lipid Nanoparticles-Encapsulated YF4: A Potential Therapeutic Oral Peptide Delivery System for Hypertension Treatment

Zhao

Zhou

et al. 2019

Front. Pharmacol.

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Drugs are administered orally in the clinical treatment of hypertension. Antihypertensive peptides have excellent angiotensin converting enzyme inhibitors activity in vitro . However, the poor oral bioavailability and therapeutic effect of antihypertensive peptides were mainly caused by rapid degradation in gastrointestinal and the short circulation time in blood, which remain to be further optimized. Therefore, the novel oral peptide delivery system is urged to improve the oral absorption and efficacy of peptide drugs. In this work, Tyr-Gly-Leu-Phe (YF4)-loaded lipid nanoparticles (YF4-LNPs) combined the advantages of polymer nanoparticles and liposomes were developed, which could greatly enhance the oral bioavailability and ameliorate the sustained release of peptide drug. YF4 loaded nanoparticles (YF4-NPs) were firstly prepared by a double-emulsion internal phase/organic phase/external phase (W1/O/W2) solvent evaporation method. YF4-NPs were further coated by membrane hydration-ultrasonic dispersion method to obtain the YF4-LNPs. The optimal YF4-LNPs showed a small particle size of 227.3 ± 3.8 nm, zeta potential of -7.27 ± 0.85 mV and high entrapment efficiency of 90.28 ± 1.23%. Transmission electronic microscopy analysis showed that the core-shell lipid nanoparticles were spherical shapes with an apparent lipid bilayer on the surface. Differential scanning calorimetry further proved that YF4 was successfully entrapped into YF4-LNPs. The optimal preparation of YF4-LNPs exhibited sustained release of YF4 in vitro and a 5 days long-term antihypertensive effect in vivo . In summary, the lipid nanoparticles for oral antihypertensive peptide delivery were successfully constructed, which might have a promising future for hypertension treatment.

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Progesterone PLGA/mPEG-PLGA Hybrid Nanoparticle Sustained-Release System by Intramuscular Injection

Abstract: Owing to the modification of PEG, PRG H-NPs can act as safe delivery platforms for sustained-release of drugs with a lower dosage required.

Cited by 11 publications

References 29 publications

Green synthesis of methoxy-poly(ethylene glycol)-block-poly(l-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo

Green synthesis of methoxy-poly(ethylene glycol)-block-poly(l-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo

Drug Transporters

Lipid Nanoparticles-Encapsulated YF4: A Potential Therapeutic Oral Peptide Delivery System for Hypertension Treatment

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