Progesterone (P) receptor dynamics in estrogen primed normal human cervix following P injection

Gorodeski, Israel G.; Geier, Avraham; Lunenfeld, Bruno; Beery, Rachel; Bahary, Charles

doi:10.1016/s0015-0282(16)49944-9

Cited by 18 publications

(11 citation statements)

References 24 publications

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“…2). A previous study has shown that whereas estrogen induces PR expression in the cervix, combination of estrogen and progesterone decreases PR to undetectable levels (29). Similarly, we have shown that the hormonal milieu, whether estrogen by itself or in combination with progesterone, as well as HPV status has varying effects on PR expression in established cervical cancer cell lines (data not shown).…”

Section: Resultssupporting

confidence: 79%

“…Interestingly, one study by Gorodeski et al has shown that treatment of patients with estrogen resulted in increased PR levels in the cervix (29). However, when progesterone was given along with estrogen to patients, PR was drastically lowered to undetectable levels (29). Similarly, we found that estrogen induces Figure 6.…”

Section: Discussionsupporting

confidence: 48%

“…Decreased PR expression in aromatase-expressing tumors suggests that estrogenic control over PR expression may be deregulated in cervical cancer. Interestingly, one study by Gorodeski et al has shown that treatment of patients with estrogen resulted in increased PR levels in the cervix (29). However, when progesterone was given along with estrogen to patients, PR was drastically lowered to undetectable levels (29).…”

Section: Discussionmentioning

confidence: 99%

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Induction of Aromatase Expression in Cervical Carcinomas: Effects of Endogenous Estrogen on Cervical Cancer Cell Proliferation

et al. 2005

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Epidemiologic studies have implicated estrogenic exposure as well as human papilloma virus (HPV) infection in cervical carcinogenesis, and some studies have suggested that estrogen and HPV may play synergistic roles in cervical tumorigenesis. In this study, we report a novel finding that f35% of cervical carcinomas tested (n = 19) express aromatase, the enzyme responsible for converting androgen to estrogen, the ratelimiting and final step in estrogen biosynthesis. On the other hand, no aromatase expression was detected in precancerous (n = 42) or normal cervical (n = 17) tissue samples. Increased aromatase was associated with increases in estrogen receptors (ER-A and ER-B) and a decrease in progesterone receptor levels, suggesting that in situ estrogen signaling via ER may be involved in tumor growth. Stable overexpression of aromatase in HPV + cervical cancer cells resulted in increased cellular proliferation, anchorage-independent growth, and ER expression and activity. In contrast, little change in ER was observed in HPV À cells. Steroid hormone receptor expression observed in vitro paralleled that seen in cervical carcinomas expressing aromatase. Aromatase overexpression also induced the expression of cyclin D1, proliferating cell nuclear antigen, and the HPV oncogenes, E6 and E7. Furthermore, the data underscores the importance of steroid receptor (estrogen and progesterone receptors) regulation in cervical carcinogenesis. To our knowledge, this is the first report demonstrating the induction of aromatase expression in cervical carcinomas, and opens the possibility that aromatase inhibitors may be potential therapeutic agents in cervical carcinomas expressing aromatase. (Cancer Res 2005; 65(23): 11164-73)

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Section: Resultssupporting

confidence: 79%

Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

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Induction of Aromatase Expression in Cervical Carcinomas: Effects of Endogenous Estrogen on Cervical Cancer Cell Proliferation

et al. 2005

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“…Specifically, progesterone promotes myometrial quiescence, down‐regulates gap junction formation, inhibits cervical ripening, and decreases the production of chemokines (i.e. IL‐8) by the chorioamniotic membranes, which is thought to be key to decidual/membrane activation 371–374 . Progesterone is considered important for pregnancy maintenance in humans because inhibition of progesterone action could result in parturition.…”

Section: Hormonal Disordersmentioning

confidence: 99%

“…Thus, a suspension of progesterone action is believed to be important for the onset of labour in humans. In contrast to the effects of progesterone, estrogens increase myometrial contractility and have been implicated in the induction of cervical ripening 371–373 …”

Section: Hormonal Disordersmentioning

confidence: 99%

The preterm parturition syndrome

Romero

Espinoza

Kusanovic

et al. 2006

BJOG

1,183

995

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The implicit paradigm that has governed the study and clinical management of preterm labour is that term and preterm parturition are the same processes, except for the gestational age at which they occur. Indeed, both share a common pathway composed of uterine contractility, cervical dilatation and activation of the membranes/decidua. This review explores the concept that while term labour results from physiological activation of the components of the common pathway, preterm labour arises from pathological signalling and activation of one or more components of the common pathway of parturition. The term 'great obstetrical syndromes' has been coined to reframe the concept of obstetrical disease. Such syndromes are characterised by: (1) multiple aetiology; (2) long preclinical stage; (3) frequent fetal involvement; (4) clinical manifestations that are often adaptive in nature; and (5) gene-environment interactions that may predispose to the syndromes. This article reviews the evidence indicating that the pathological processes implicated in the preterm parturition syndrome include: (1) intrauterine infection/inflammation; (2) uterine ischaemia; (3) uterine overdistension; (4) abnormal allograft reaction; (5) allergy; (6) cervical insufficiency; and (7) hormonal disorders (progesterone related and corticotrophinreleasing factor related). The implications of this conceptual framework for the prevention, diagnosis, and treatment of preterm labour are discussed.

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Prevention of spontaneous preterm birth: the role of sonographic cervical length in identifying patients who may benefit from progesterone treatment

Romero

2007

Ultrasound in Obstet & Gyne

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Progesterone (P) receptor dynamics in estrogen primed normal human cervix following P injection

Cited by 18 publications

References 24 publications

Induction of Aromatase Expression in Cervical Carcinomas: Effects of Endogenous Estrogen on Cervical Cancer Cell Proliferation

Induction of Aromatase Expression in Cervical Carcinomas: Effects of Endogenous Estrogen on Cervical Cancer Cell Proliferation

The preterm parturition syndrome

Prevention of spontaneous preterm birth: the role of sonographic cervical length in identifying patients who may benefit from progesterone treatment

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