Progesterone oral contraception and blood coagulation.

Poller, L.; Thomson, Jean M.; Tabiowo, Anne; Priest, Celia M.

doi:10.1136/bmj.1.5643.554

Cited by 68 publications

(19 citation statements)

References 7 publications

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“…Perhaps more significant and important, however, is the fact that the shortened aggregation times in women who were taking combined preparations lengthen to normal during the first month of chlormadinone acetate. It may be recalled that the raised clotting factors in this same group reported elsewhere also fell towards normal on progestogen, but this took longer (Poller et al, 1969b). It should be emphasized that these results, though encouraging, reflect changes to only the sixth-month stage.…”

Section: Discussionsupporting

confidence: 68%

“…We have shown previously that platelet aggregation in the A.D.P.-induced optical density system is insensitive to the clotting factor changes which affect platelet aggregation (Poller et al, 1969a, and1969b). Bolton et al (1968) studied platelet sensitivity to A.D.P., using an electrophoretic technique, and in contrast to our present findings found increased sensitivity in women taking combined preparations.…”

Section: Discussioncontrasting

confidence: 64%

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Platelet aggregation during oral contraception

Poller¹,

Priest²,

Thomson³

1969

BMJ

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British MedicalJournal, 1969, 4, 273-274 ummary: Platelet aggregation has been found to be significantly accelerated with the coagulation-inducedChandler's tube technique in women taking combined oestrogen-progestin oral contraceptives, though this was less than in the third trimester of pregnancy. Women taking the pure progestogen, chlormadinone acetate, have not shown this change up to the sixth month of study. In contrast the accelerated platelet aggregation resulting from conventional oral contraception became normal one month after changing to the progestogen. There was no change in the platelet aggregation response to adenosino diphosphate (A.D.P.) during oral contraception. IntroductionOral contraception with conventional oestrogen-progestin preparations results in rises of clotting factors, including factor X, which is involved in the " intrinsic " clotting system (Poller and Thomson, 1966). When this mechanism is accelerated by physical exertion the platelet aggregation time may also be shortened (Poller et at., 1969c).We therefore carried out studies in women taking a variety

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Section: Discussionsupporting

confidence: 68%

Section: Discussioncontrasting

confidence: 64%

Platelet aggregation during oral contraception

Poller¹,

Priest²,

Thomson³

1969

BMJ

Self Cite

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“…Poller et al (18) and Bloom et al (2) reported that women on low doses of progestogens had normal levels of factors VII and X. Nilsson et al (17) found un-…”

Section: Discussionmentioning

confidence: 96%

Concentration of Antithrombin III During Combined and Progestogen‐Only Oral Contraceptive Treatment

Larsson‐Cohn

Fagerhol

Abildgaard

1972

Acta Obstet Gynecol Scand

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“…The active component of contraceptive agents affecting factor VII, is thought to be oestrogen, as progestogens alone do not alter factor VII levels [11], Therefore, the occurrence of a rise in factor VII in the second half of the cycle suggests that an accumulation of oestrogen is required. The site and mode of action of oestrogen is unknown, but other proteins produced by the liver are also increased, e.g.…”

Section: Discussionmentioning

confidence: 99%