Progesterone mediates decreases in uterine smooth muscle cell interleukin-1α by a mechanism involving decreased stability of IL-1α mRNA.

Lan, Lan; Vinci, James M.; Melendez, J. Andrés; Jeffrey, John J.; Wilcox, Brian D.

doi:10.1016/s0303-7207(99)00066-0

Cited by 12 publications

(15 citation statements)

References 37 publications

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“…This result is compatible with the hypothesis that progesterone inhibits the inflammatory response to maintain uterine quiescence (Lan et al. ).…”

Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

“…Pregnant rats were treated daily beginning on GD19 with P4 (medroxyprogesterone acetate, 16 mg/kg/day, subcutaneous injection in 0.4 mL corn oil containing 10% ethanol (s.c.); Sigma-Aldrich, Oakville, ON) (Lan et al 1999;Romero et al 2006;Sadowsky et al 2000;Schober et al 2012;Shynlova et al 2004Shynlova et al , 2005. The P4-treated dams were killed on GD 21 and 23 (n = 4-5 at each time point), and the tissue samples (upper uterus and lower uterus) were collected.…”

Section: Progesterone-treated Groupmentioning

confidence: 99%

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Interleukin (IL)‐1 in rat parturition: IL‐1 receptors 1 and 2 and accessory proteins abundance in pregnant rat uterus at term – regulation by progesterone

Ishiguro

Takeda

Fang

et al. 2016

Physiological Reports

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The role of interleukin‐1 (IL‐1), a pro‐inflammatory cytokine, in parturition is typically noted by changes in its concentrations. Studying the expression of its receptor family, IL‐1 receptor (IL‐1R) 1, IL‐1R2, IL‐1R accessory protein (IL‐1RAcP), and its predominantly brain isoform, IL‐1RAcPb, during late gestation in the uterus in the Long‐Evans rat is another. We assessed changes in their mRNA and protein relative abundance in the uterus and compared IL‐1RAcP and IL‐1RAcPb mRNA abundance in uterus, cervix, ovaries, placenta, and whole blood of Long‐Evans rats during late gestation or in RU486 and progesterone‐treated dams using quantitative real‐time PCR and western immunoblotting. IL‐1R1, IL‐1RAcP, and IL‐1RAcPb mRNA abundance significantly increased in the uterus at delivery whereas IL‐1R2 mRNA abundance significantly decreased. IL‐1R1 protein increased at term and IL‐1R2 protein decreased at term compared to nonpregnant uteri. IL1‐RAcPb mRNA abundance was less than IL‐1RAcP, but in the lower uterine segment it was the highest of all tissues examined. RU486 stimulated preterm delivery and an increase in IL‐1R1 mRNA abundance whereas progesterone administration extended pregnancy and suppressed the increase in IL‐1R1. These data suggest that changes in uterine sensitivity to IL‐1 occur during late gestation and suggest another level of regulation for the control of delivery. The roles for IL‐1RAcP and IL‐1RAcPb need to be determined, but may relate to different intracellular signaling pathways.

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“…This result is compatible with the hypothesis that progesterone inhibits the inflammatory response to maintain uterine quiescence (Lan et al. ).…”

Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Progesterone-treated Groupmentioning

confidence: 99%

See 1 more Smart Citation

Interleukin (IL)‐1 in rat parturition: IL‐1 receptors 1 and 2 and accessory proteins abundance in pregnant rat uterus at term – regulation by progesterone

Ishiguro

Takeda

Fang

et al. 2016

Physiological Reports

View full text Add to dashboard Cite

show abstract

“…Cytokines are recognized as small and nonstructural proteins, which are pleiotropic and have multiple diverse biological activities [19]. As revealed by Lan et al [20], progesterone could decrease IL-1␣ levels by stimulating the production of an intracellular intermediate that decreased the stability of IL-1␣ mRNA. Other research [21] indicated that the abundant expression of TNF-␣ might be a molecular basis characteristic of leiomyomas in the human uterus and that progesterone might play a vital role in down-regulating the expression of TNF-␣ in human uterine leiomyoma.…”

Section: Discussionmentioning

confidence: 99%

Effects of Progesterone on Intestinal Inflammatory Response, Mucosa Structure Alterations, and Apoptosis Following Traumatic Brain Injury in Male Rats

Chen

Shi

et al. 2008

Journal of Surgical Research

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“…Telleria et al reported that progesterone can efficiently inhibit the expression of IL-6 in the corpus luteum [90]. Lan et al revealed that progesterone reduced the consistency of IL-1β mRNA [91], and Pioli et al reported that estradiol decreased IL-8 production in monocytes. It has been also shown that estrogen increased intestinal levels of IL-6 and IL-1β following TBI [85].…”

Section: Tbi Gi Tract and Sex Hormonesmentioning

confidence: 99%

Traumatic Brain Injury and the Gastrointestinal Tract: The Role of Female Sexual Hormones

et al. 2017

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Traumatic brain injury (TBI) is an important public health problem which can lead to several complications like gastrointestinal dysfunction. Patients with TBI often suffer from gastrointestinal dysfunctions such as enteral feeding intolerance. Gastric ulceration is induced by various forms of stress like surgery, ischemia and trauma. TBI causes a delayed but significant decrease in intestinal contractile activity in the ileum leading to delayed transport. The association between severity of brain injury and enteral feeding intolerance suggests a strong link between the central nervous system and the non-functional gut. The results of recent basic and clinical studies revealed the beneficial effects of estrogen and progesterone hormones in the treatment of gastrointestinal dysfunction. Females have more resistance to stress and fewer gastrointestinal lesions occur in females as compared to males. Sex steroid hormones have sparked interest as possible neuroprotective agents after traumatic injury and many studies have been done on this subject. This article reviews the literature related to some possible physiological effects of female sexual hormones on the gastrointestinal tract following TBI.

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Progesterone mediates decreases in uterine smooth muscle cell interleukin-1α by a mechanism involving decreased stability of IL-1α mRNA.

Cited by 12 publications

References 37 publications

Interleukin (IL)‐1 in rat parturition: IL‐1 receptors 1 and 2 and accessory proteins abundance in pregnant rat uterus at term – regulation by progesterone

Interleukin (IL)‐1 in rat parturition: IL‐1 receptors 1 and 2 and accessory proteins abundance in pregnant rat uterus at term – regulation by progesterone

Effects of Progesterone on Intestinal Inflammatory Response, Mucosa Structure Alterations, and Apoptosis Following Traumatic Brain Injury in Male Rats

Traumatic Brain Injury and the Gastrointestinal Tract: The Role of Female Sexual Hormones

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