Progesterone level significance in agonist versus antagonist protocols

Bushaqer, Nayla; Mohawash, Wadha; Alrakaf, Fatima; Algaffli, Meshael; Rawah, Haya; Dayoub, Nawal; Ayoub, Hisham; Alasmari, Nouf

doi:10.1016/j.mefs.2017.09.010

Cited by 1 publication

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study ( Bushaqer et al ., 2018 ) compared the effect of elevated progesterone in agonist and antagonist cycles and concluded that clinical pregnancy rates were adversely affected only in antagonist cycles, although this was not replicated in other studies. Our study found no significant difference between clinical pregnancy rates with respect to different protocols used.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical significance of increased follicular phase progesterone levels and its impact on pregnancy rates have been addressed, but conclusions are far from decisive. Although some postulate an adverse effect on ART outcome ( Melo et al ., 2006 ; Racca et al ., 2018 ), others state that there is no significant effect on implantation or clinical pregnancy rates ( Vanni et al ., 2017 ; Bushaqer et al ., 2018 ). Considering the ambiguity, this study was conducted with the objective to investigate the relationship between progesterone levels on the day of hCG trigger and IVF outcomes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum progesterone on the day of human chorionic gonadotropin (hCG) trigger as a predictor of in-vitro fertilization (IVF) outcome – a retrospective analysis of seven years

Yadav¹,

Noor²,

Mahey³

et al. 2022

JBRA

View full text Add to dashboard Cite

Objective: To investigate the relationship between progesterone (P4) levels on the day of hCG trigger and IVF outcomes.Methods: This is a retrospective analysis of IVF cycles from January-2013 to December-2019 from a single center. Women (21-39 years) submitted to IVF treatment for various infertility factors were included, while donor oocyte cycles and cancelled cycles were excluded from the study. The primary outcome measure was live birth rate.Results: A total of 2149 cycles were analyzed. Of these, 223 (10.38%) were in the low P4 group (<0.5 ng/ml), 1163 (54.12%) in the normal P4 group (0.5-1.5 ng/ml), and 763 (35.50%) in the high P4 group (>1.5ng/ml). The groups were comparable with respect to age, factor of infertility and baseline AMH. The antagonist protocol was significantly more prescribed to the high P4 group (p<0.001). Live birth rates were 14.4%, 21.6%, and 21% (p<0.001), respectively, in three groups. Univariate analysis found that total cetrotide dose, total number of retrieved and fertilized oocytes, total number of embryos formed, transferred, and vitrified, and P4 on the day of hCG (p<0.001) were statistically significant after adjusting for age and BMI. In multivariate logistic regression after adjusting for age and BMI, only high P4 (aOR:0.60; p<0.001), total cetrotide dose (aOR: 0.82; p<0.001), and total utilizable embryos (aOR:1.11; p=0.029) were statistically significant.Conclusions: Having an elevated serum progesterone level on the day of hCG trigger was associated with lower pregnancy rates, but this is still not a robust marker to predict live births. More good quality evidence is needed.

show abstract

Section: Discussionmentioning

confidence: 99%