Progesterone induced blocking factor (PIBF) taken in early pregnancy predicts the pregnancy outcome in women undergoing in vitro fertilization procedure

Hudić, Igor; Szekeres-Barthó, Júlia; Vrtačnik, Eda Bokal; Klun, Irma Virant; Brkić, Selmira; Frangež, Helena Ban; Jančar, Nina; Mešalić, Lejla; Bogdan, A. T.; Hudić, Larisa Dizdarević

doi:10.1016/j.jri.2020.103150

Cited by 14 publications

(17 citation statements)

References 25 publications

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“…Simultaneously, in animals treated with anti-PIBF antibodies, the gene for IL-4 is significantly downregulated in CD4+ cells while that of IL-12A is upregulated in CD8+ cells ( 28 ). In a preeclampsia rat model, PIBF treatment normalized the Th1/Th2 ratio, reduced the inflammation, corrected the blood pressure and prevented foetal growth restriction ( 35 ).…”

Section: Progesterone-dependent Immunoregulationmentioning

confidence: 99%

Cytokines, Hormones and Cellular Regulatory Mechanisms Favoring Successful Reproduction

et al. 2021

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Its semi-allogeneic nature renders the conceptus vulnerable to attack by the maternal immune system. Several protective mechanisms operate during gestation to correct the harmful effects of anti-fetal immunity and to support a healthy pregnancy outcome. Pregnancy is characterized by gross alterations in endocrine functions. Progesterone is indispensable for pregnancy and humans, and it affects immune functions both directly and via mediators. The progesterone-induced mediator - PIBF - acts in favor of Th2-type immunity, by increasing Th2 type cytokines production. Except for implantation and parturition, pregnancy is characterized by a Th2-dominant cytokine pattern. Progesterone and the orally-administered progestogen dydrogesterone upregulate the production of Th2-type cytokines and suppress the production of Th1 and Th17 cytokine production in vitro. This is particularly relevant to the fact that the Th1-type cytokines TNF-α and IFN-γ and the Th17 cytokine IL-17 have embryotoxic and anti-trophoblast activities. These cytokine-modulating effects and the PIBF-inducing capabilities of dydrogesterone may contribute to the demonstrated beneficial effects of dydrogesterone in recurrent spontaneous miscarriage and threatened miscarriage. IL-17 and IL-22 produced by T helper cells are involved in allograft rejection, and therefore could account for the rejection of paternal HLA-C-expressing trophoblast. Th17 cells (producing IL-17 and IL-22) and Th22 cells (producing IL-22) exhibit plasticity and could produce IL-22 and IL-17 in association with Th2-type cytokines or with Th1-type cytokines. IL-17 and IL-22 producing Th cells are not harmful for the conceptus, if they also produce IL-4. Another important protective mechanism is connected with the expansion and action of regulatory T cells, which play a major role in the induction of tolerance both in pregnant women and in tumour-bearing patients. Clonally-expanded Treg cells increase at the feto-maternal interface and in tumour-infiltrating regions. While in cancer patients, clonally-expanded Treg cells are present in peripheral blood, they are scarce in pregnancy blood, suggesting that fetal antigen-specific tolerance is restricted to the foeto-maternal interface. The significance of Treg cells in maintaining a normal materno-foetal interaction is underlined by the fact that miscarriage is characterized by a decreased number of total effector Treg cells, and the number of clonally-expanded effector Treg cells is markedly reduced in preeclampsia. In this review we present an overview of the above mechanisms, attempt to show how they are connected, how they operate during normal gestation and how their failure might lead to pregnancy pathologies.

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Section: Progesterone-dependent Immunoregulationmentioning

confidence: 99%

Cytokines, Hormones and Cellular Regulatory Mechanisms Favoring Successful Reproduction

et al. 2021

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“…T. Iba et al считают, что при COVID-19 возникает местная и системная гиперкоагуляция [28]. По их мнению, местная гиперкоагуляция обусловлена микроангиопатией, в то время как системная связана с дефектом свертывания крови, который приводит к тромбозу крупных сосудов и является причиной развития тромбоэмболии легочной артерии.…”

Section: патологическая анатомия поражения сосудов легких при Covid-19unclassified

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2022

Clin. Exp. Morphology

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Тираж 500 экземпляров Издательство «Группа МДВ» www.mdv-group.ru Подписные индексы: 70045 по каталогу агентства «Урал-Пресс» 70045 по каталогу «Пресса России» через агентство АРЗИ Свидетельство о регистрации средства массовой информации ПИ № ФС77-47183 от 2 ноября 2011 года. © НИИ морфологии человека им. акад. А.П. Авцына ФГБНУ РНЦХ им. акад. Б.В. Петровского

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“…PIBF is present in the urine and the sera of pregnant women. In serum samples of in vitro fertilization (IVF) patients PIBF was detected 14 days after embryo transfer [67], and later the serum concentrations increased by gestational age in uneventful pregnancies [68]. Lower than normal concentrations predict spontaneous pregnancy termination [69,70] as shown by the finding that not only decidual PR and PIBF expression, but also the serum concentrations of PIBF are characteristically low in women with unexplained miscarriages in [71].…”

Section: Pibf In Pregnancymentioning

confidence: 99%

Progesterone induced blocking factor in health and disease

Szekeres-Barthó

2021

Explor Immunol

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The foetus expressing paternal antigens ought to be “rejected” by the maternal immune system. However, the immunological relationship of the mother and the foetus does not follow the rules of transplantation immunology. Maternal immune functions are re-adjusted during pregnancy, to create a tolerant environment for the developing foetus. Progesterone and its downstream mediator; the progesterone induced blocking factor (PIBF) are important in this process. The mRNA transcribed from the PIBF1 gene contains 18 exons, and codes for a 90 kDa protein. The 90 kDa form is associated with the centrosome and plays a role in cell cycle regulation, while smaller isoforms produced by alternative spicing are secreted, and bind to the glycosylphosphatidylinositol (GPI) anchored PIBF receptor. Upon ligation, the former forms a heterodimer with the alpha chain of the interleukin-4 (IL-4) receptor and activates the Janus kinase/signal transducers and activators of transcription (Jak/STAT) pathway, via which, PIBF induces increased production of T helper2 (Th2) cytokines. PIBF regulates natural killer (NK) cytotoxicity, by inhibiting perforin release from the cytoplasmic granules of NK cells. During normal human pregnancy, the serum concentrations of PIBF increase with gestational age, and lower than normal serum levels predict spontaneous pregnancy termination. Depletion of PIBF during the peri-implantation period in mice, results in lower implantation and increased resorption rates, together with increased decidual and peripheral NK activity, downregulation of the genes implicated in T cell activation in CD4+ cells, and Th1 differentiation of the T cells. PIBF is expressed in rapidly proliferating immature cells as well as several tumours, and regulates invasion. The PIBF gene has been identified in the chromosomal region 13q21-q22—which is a common site for somatic deletions in a variety of malignant tumours. These data suggest that PIBF might be involved in tumorigenesis.

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Progesterone induced blocking factor (PIBF) taken in early pregnancy predicts the pregnancy outcome in women undergoing in vitro fertilization procedure

Cited by 14 publications

References 25 publications

Cytokines, Hormones and Cellular Regulatory Mechanisms Favoring Successful Reproduction

Cytokines, Hormones and Cellular Regulatory Mechanisms Favoring Successful Reproduction

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Progesterone induced blocking factor in health and disease

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