Progesterone-Independent Activation of Rat Brain Progestin Receptors by Reproductive Stimuli

Auger, Anthony P.; Moffatt, Christopher A.; Blaustein, Jeffrey D.

doi:10.1210/endo.138.1.4986

Cited by 59 publications

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“…It is not surprising that repeated testing increases the level of sexual behavior in non-premated females. A considerable body of research suggests that repeated mating of female rats enhances sexual receptivity in females that have not been premated (Auger et al, 1997;Bennett et al, 2001;Dudley and Moss, 1994;Foreman and Moss, 1977;Hardy and DeBold, 1973;Rajendren et al, 1990;1991;Moss, 1993, 1994). Although these increases in sexual behavior have been attributed mainly to VCS received during mating (Bennett et al, 2001), it is important to note that under some experimental conditions repeated mating in the absence of intromissions is sufficient to increase sexual behavior (Hardy and DeBold, 1973).…”

Section: Figmentioning

confidence: 99%

“…Activation of progestin receptors by progesterone causes down-regulation of the receptors, which induces hyposensitivity to progesterone, resulting in a loss of the behavioral response (Blaustein and Olster, 1989). Because mating stimulation, particularly VCS, is believed to cause ligand-independent activation of progestin receptors (Auger et al, 1997), it is possible that mating stimulation also induces down-regulation of progestin receptors leading to the hastened termination of sexual receptivity. Alternatively, it has been suggested that activation of estrogen receptor-␤ (ER␤)-containing cells may contribute to the termination of sexual behavior (Greco, Blasberg, Kosinski, and Blaustein, unpublished results).…”

Section: Figmentioning

confidence: 99%

“…Several studies suggest that repeated mating can alter the expression of female sexual behavior (Auger, Moffatt, and Blaustein, 1997;Bennett, Blasberg, and Blaustein, 2001;Dudley and Moss, 1994;Foreman and Moss, 1977;Hardy and DeBold, 1973;Rajendren, Dudley, and Moss, 1990;Rajendren, Dudley, and Moss, 1991;Moss, 1993, 1994). Although VCS seems to be important for these alterations (Bennett et al, 2001), other sensory cues such as odors (Rajendren et al, 1991;Rajendren and Moss, 1994) and other types of tactile stimulation (Hardy and DeBold, 1973) also contribute to the effects of repeated mating on subsequent behavior.…”

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confidence: 99%

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Mating Stimulation Required for Mating-Induced Estrous Abbreviation in Female Rats: Effects of Repeated Testing

Bennett

Blasberg

Blaustein

2002

Hormones and Behavior

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Mating stimulation, particularly vaginal-cervical stimulation, causes estrous abbreviation in female rats. In most previous studies, female rats were repeatedly tested for sexual behavior until estrous termination occurred. Thus, it was not clear whether sensory stimulation (e.g., flank stimulation, olfactory cues) received during the repeated testing procedure contributed to estrous abbreviation. In Experiment 1, we determined the effect of premating to two or four ejaculations on the rate of estrous termination when a repeated testing procedure was used. We compared ovariectomized, hormone-primed, female rats receiving (1) four ejaculations, (2) two ejaculations, or (3) no premating. Females premated to either two or four ejaculations showed significantly lower levels of sexual receptivity 12 h later than did nonpremated females. These results confirm that premating induces estrous abbreviation when a repeated testing procedure is used. In Experiment 2, we determined whether the repeated testing procedure was necessary for estrous abbreviation. Ovariectomized, hormone-primed female rats were premated to two ejaculations or not premated. The rats were then tested for sexual behavior repeatedly or only once. Females that were premated and repeatedly tested for sexual behavior showed a statistically significant decrease in sexual receptivity compared to females that were not premated; however, the level of sexual receptivity in premated females did not differ from that in non-premated females when they were tested only once. The results suggest that heat duration is the result of a complex interplay between those factors that promote the expression of sexual receptivity and those that inhibit it.

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Section: Figmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

mentioning

confidence: 99%

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Mating Stimulation Required for Mating-Induced Estrous Abbreviation in Female Rats: Effects of Repeated Testing

Bennett

Blasberg

Blaustein

2002

Hormones and Behavior

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“…There is no difference in lordosis quotients between rats pretreated with the progestin antagonist RU486 and rats treated with oil vehicle, indicating that a neuronal component that is not dependent upon progestin receptors is activated by VCS. However, RU486-treated female rats placed in an arena with a sexually active male 15 min after VCS show lower sexual receptivity than do the oil-treated controls (Auger et al, 1997). Although RU486-treated females have the capacity to show a similar degree of lordosis to that displayed by oil-treated rats receiving VCS, RU486-treated females show less sexual behaviour in the presence of a male.…”

Section: Ligand-independent Activation Of Progestin Receptors In Vivomentioning

confidence: 82%

“…Each mating test takes 15 min and is separated by a 15 min nonexposure period. Sexual receptivity in control-treated female rats is increased by the third and fourth mating test; however, this increase is inhibited completely in rats injected with the progestin antagonist RU486 (Auger et al, 1997). Therefore, progestin receptors appear to be important in mediating mating-induced increases in sexual behaviour even in the absence of circulating progesterone.…”

Section: Ligand-independent Activation Of Progestin Receptors In Vivomentioning

confidence: 95%

Ligand-independent activation of progestin receptors: relevance for female sexual behaviour

Auger

2001

Reproduction

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is, by ligand-or steroid-independent activation. More importantly, ligand-independent activation of steroid receptors (that is, progestin receptors) within the brain can influence reproductive behaviour in rodents. This review focuses on recent findings which indicate that some somatosensory cues normally experienced by females, such as those associated with sexual contact with males, can activate progestin receptors to influence both neuronal response and oestrous behaviour in a ligand-independent manner. Hormonal requirements for the induction of sexual behaviourDuring the oestrous cycle in rats, sexual behaviour is dependent upon an increase in serum oestradiol followed by an increase in progesterone concentrations. Sexual behaviour is abolished by ovariectomy, and reinstated by the injection of oestradiol followed 1 or 2 days later by progesterone. Treatment with oestradiol alone can induce some aspects of sexual behaviour, such as receptivity (for example, lordosis); however, oestradiol followed by progesterone administration induces the full complement of proceptive behaviours that occur during normal oestrus, such as ear wiggling, hopping and darting behaviour (Blaustein and Olster, 1989). This finding indicates that both oestradiol and progesterone are critical for the occurrence of normal oestrous behaviour. Oestradiol and progesterone are secreted from both the ovaries and the adrenal glands (Shaikh and Shaikh, 1975). Steroid hormone secretion from the adrenal glands appears to be important for the normal timing of sexual behaviour in rats, as stress resulting from sham ovariectomy advances, and stress resulting from adrenalectomy delays, the onset of oestrous behaviour. In addition, the small increase in solicitational behaviour induced by oestradiol treatment alone is blocked by adrenalectomy. Therefore, sexual behaviour is influenced by secretion of steroid hormones not only from the ovary, but also from the adrenal glands. Behavioural and physiological changes associated with mating stimulationWhen mating occurs, the female rat experiences a variety of somatosensory and olfactory stimuli from the male that further influences female sexual behaviour (Pfaff et al., 1994). For example, ovariectomized rats primed with low doses of oestradiol exhibit reduced lordosis in the presence of a sexually active male; however, repeated exposure of ovariectomized oestradiol-primed female rats to males will induce increased lordosis (Hardy and Debold, 1973). The increase in lordosis owing to repeated mating of oestradiolprimed female rats occurs within an hour, and this behavioural phenomenon is not dependent upon the adrenal glands (Foreman and Moss, 1977). Therefore, mating-related stimuli increase sexual receptivity in the absence of circulating progesterone. It is not clear which somatosensory and olfactory cues are important for mediat-

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A neural mechanism of nuclear receptor expression and regionalization

Cabej

2020

Developmental Dynamics

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Spatially restricted expression of genes by global circulating inducers (hormones, secreted proteins, growth factors, neuromodulators, etc.) was a prerequisite for the evolution of animals. Far from a random occurrence, it is a systematically occurring, certain event, implying that specific information is invested for it to happen. In this minireview, we show for the first time that the expression and regionalization takes place at the level of receptors via a neural mechanism and make an attempt to reconstruct the causal chain from neural signaling to expression of nuclear receptors.

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Progesterone-Independent Activation of Rat Brain Progestin Receptors by Reproductive Stimuli

Cited by 59 publications

References 0 publications

Mating Stimulation Required for Mating-Induced Estrous Abbreviation in Female Rats: Effects of Repeated Testing

Mating Stimulation Required for Mating-Induced Estrous Abbreviation in Female Rats: Effects of Repeated Testing

Ligand-independent activation of progestin receptors: relevance for female sexual behaviour

A neural mechanism of nuclear receptor expression and regionalization

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