Progesterone increases the activity of glutamate transporter type 3 expressed in Xenopus oocytes

Son, Ilsoon; Shin, Hyung-Jin; Ryu, Jin Suk; Kim, Hae-Kyoung; Hwan, Sang; Zuo, Zhiyi

doi:10.1016/j.ejphar.2013.03.053

Cited by 1 publication

(1 citation statement)

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“…In a study by Cyr et al [127] , progesterone treatment in OVX rats was found to decrease NMDA but not AMPA binding density in the frontal cortex, and had no effect in the hippocampus, dentate gyrus, striatum, and nucleus accumbens. Another study showed significantly enhanced EAAT3 activity after progesterone treatment performed in frog oocytes [141] . Mitrovic et al [142] studied this association in cell cultures from rat brain and similarly found that EAAT affinity for glutamate was highest during proestrous and estrous periods, which are characterized by peak levels of both estradiol and progesterone.…”

Section: Progesterone and Glutamatementioning

confidence: 99%

Effect of Gonadal Hormones on Neurotransmitters Implicated in the Pathophysiology of Obsessive-Compulsive Disorder: A Critical Review

Karpinski

Mattina

Steiner³

2016

Neuroendocrinology

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Obsessive-compulsive disorder (OCD) is a relatively common neuropsychiatric disorder affecting between 1.6 and 3.2% of the population. A number of studies have previously reported increased incidence of OCD, or exacerbation of preexisting symptoms in females during reproductive events. Since these periods are known to involve fluctuating levels of gonadal hormones, these steroids have been suggested to be involved in modulating the course of the disorder. However, to date, only a few studies have measured hormone levels and obsessive-compulsive (OC) symptoms concurrently; thus, direct evidence for this relationship is limited. In turn, investigations into neurotransmission in OC individuals have been more extensive, and have implicated the serotonergic, dopaminergic, and glutamatergic neurotransmitter systems in OCD pathology. There is evidence suggesting that reproductive hormones estrogens and progesterone can modulate neurotransmission in the aforementioned signaling pathways by regulating the expression of receptors and channels, as well as the synthesis and release of the neurotransmitter itself. Overall, estrogen and progesterone appear to enhance serotonin signaling, which has been associated with improved OC symptoms. The effect of the gonadal hormones in dopaminergic and glutamatergic signaling is much more variable, highlighting the need for further research in this field. The existing evidence shows that gonadal hormones can have profound impacts on neurotransmission in the brain, leading to the conclusion that the hormonal fluctuations during reproductive events are a plausible factor contributing to the change in OCD course during these times.

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Section: Progesterone and Glutamatementioning

confidence: 99%