Progestérone et progestatifs de synthèse

Rozenbaum, H

doi:10.1016/s0246-1064(09)43131-1

Cited by 4 publications

(7 citation statements)

References 62 publications

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“…62−64 Besides progestagenic activity, synthetic norgestrel could also exhibit androgenic activity. 10,11 In addition to the parent compounds, those biodegradation products might have different biological effects. For example, the four androgens (Products 1−4) generated from progesterone could cause masculization of fish.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Degradation of Norgestrel by Bacteria from Activated Sludge: Comparison to Progesterone

Liu¹,

Ying²,

Yousheng³

et al. 2013

Environ. Sci. Technol.

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Natural and synthetic progestagens in the environment have become a concern due to their adverse effects on aquatic organisms. Laboratory studies were performed to investigate aerobic biodegradation of norgestrel by bacteria from activated sludge in comparison with progesterone, and to identify their degradation products and biotransformation pathways. The degradation of norgestrel followed first order reaction kinetics (T 1/2 = 12.5 d), while progesterone followed zero order reaction kinetics (T 1/2 = 4.3 h). Four and eight degradation products were identified for norgestrel and progesterone, respectively. Six norgestrel-degrading bacterial strains (Enterobacter ludwigii, Aeromonas hydrophila subsp. dhakensis, Pseudomonas monteilii, Comamonas testosteroni, Exiguobacterium acetylicum, and Chryseobacterium indologenes) and one progesterone-degrading bacterial strain (Comamonas testosteroni) were successfully isolated from the enrichment culture inoculated with aerobic activated sludge. To our best knowledge, this is the first report on the biodegradation products and degrading bacteria for norgestrel under aerobic conditions.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Degradation of Norgestrel by Bacteria from Activated Sludge: Comparison to Progesterone

Liu¹,

Ying²,

Yousheng³

et al. 2013

Environ. Sci. Technol.

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“…According to clinical studies, the progestagenic potency of norgestrel is approximately 1000 times higher than that of progesterone (King and Whitehead, 1986;Stanczyk, 2003). In addition, synthetic progestagens may also have other hormonal activities, such as estrogenic, antiandrogenic, and androgenic activities (Rozenbaum, 2001;Schindler et al, 2003). A previous study indicated that synthetic progestagens are capable of inhibiting reproduction in Water (ng/L) Sediment (ng/g dw) a APL (ng/g ww) ML (ng/g ww) TK (ng/g ww) CP (ng/g ww) Adult LR (ng/g ww) Adult LE (ng/g ww) Water (ng/L) Sediment (ng/g dw) ORG (ng/g ww)…”

Section: Free Steroids In the Water Samplesmentioning

confidence: 99%

Steroids in marine aquaculture farms surrounding Hailing Island, South China: Occurrence, bioconcentration, and human dietary exposure

Liu

Chen

et al. 2015

Science of The Total Environment

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“…111 112 2.2 Mechanism of action and activity of gestagens in mammals: 113 114 Natural progesterone (P4) has progestagenic, anti-estrogenic, anti-aldosterone and mild anti-115 androgenic activities. P4 mainly acts through the progesterone nuclear receptors PRA and 116 PRB and modifies the transcription of target genes (Rozenbaum, 2001). The main genomic 117 activities are: 118…”

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confidence: 99%

“…Such effects are reported to be faster than genomic 127 effects (hours versus days) and can trigger different metabolic reactions and receptors 128 (GABA, NMDA and acetylcholine receptors). P4 plays a role in oocyte maturation and 129 modulation of reproductive signaling in the brain, but also has a sedating action by 130 potentiating the GABA effect on GABA(A) receptors or can impair the glucose metabolism 131 (Hardman et al, 1996;Rozenbaum, 2001;Pharmacorama, 2008). 132…”

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confidence: 99%

Progestagens for human use, exposure and hazard assessment for the aquatic environment

Besse¹,

Garric²

2009

Environmental Pollution

123

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32Little information is available on the environmental occurrence and ecotoxicological effects 33 of pharmaceutical gestagens released in the aquatic environment. Since eighteen different 34 gestagens were found to be used in France, preliminary exposure and hazard assessment were 35 done. Predicted environmental concentrations (PECs) suggest that if parent gestagens are 36 expected to be found in the ng.l −1 range, some active metabolites could be present at higher 37 concentrations, although limited data on metabolism and environmental fate limit the 38 relevance of PECs. The biological effects are not expected to be restricted to progestagenic 39 activity. Both anti-androgenic activity (mainly for cyproterone acetate, chlormadinone acetate 40 and their metabolites) and estrogenic activity (mainly for reduced metabolites of 41 levonorgestrel and norethisterone) should also occur.

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Progestérone et progestatifs de synthèse

Cited by 4 publications

References 62 publications

Degradation of Norgestrel by Bacteria from Activated Sludge: Comparison to Progesterone

Degradation of Norgestrel by Bacteria from Activated Sludge: Comparison to Progesterone

Steroids in marine aquaculture farms surrounding Hailing Island, South China: Occurrence, bioconcentration, and human dietary exposure

Progestagens for human use, exposure and hazard assessment for the aquatic environment

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