Progesterone control of myometrial contractility

Shynlova, Oksana; Nadeem, Lubna; Lye, Stephen

doi:10.1016/j.jsbmb.2023.106397

Cited by 3 publications

(6 citation statements)

References 197 publications

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“…Here, we try to review the potential reason through which progesterone exerts its effects [ 22 , 99 ]. Progesterone have capability to control of myometrial contractility.…”

Section: Progesterone and Preterm Birthmentioning

confidence: 99%

“…Progesterone have capability to control of myometrial contractility. The action of progesterone hinges on two nuclear progesterone receptors: PR-A and PR-B, which originate from the same gene and are co-expressed throughout pregnancy [ 22 , 99 ]. PR-B is typically acknowledged as a transcriptional activator of genes downstream of progesterone, while PR-A exerts an inhibitory effect on PR-B [ 99 ].…”

Section: Progesterone and Preterm Birthmentioning

confidence: 99%

“…The action of progesterone hinges on two nuclear progesterone receptors: PR-A and PR-B, which originate from the same gene and are co-expressed throughout pregnancy [ 22 , 99 ]. PR-B is typically acknowledged as a transcriptional activator of genes downstream of progesterone, while PR-A exerts an inhibitory effect on PR-B [ 99 ]. Previous research indicated that a high PR-A/PR-B ratio in the myometrium could hamper P4/PR-B-mediated transcriptional responses affected by the local immune environment [ 31 , 99 ].…”

Section: Progesterone and Preterm Birthmentioning

confidence: 99%

“…PR-B is typically acknowledged as a transcriptional activator of genes downstream of progesterone, while PR-A exerts an inhibitory effect on PR-B [ 99 ]. Previous research indicated that a high PR-A/PR-B ratio in the myometrium could hamper P4/PR-B-mediated transcriptional responses affected by the local immune environment [ 31 , 99 ]. In other words, under conditions of hyperinflammation, NF-κB/AP-1 pathways mediate an increase in the expression of 20α-Hydroxysteroid Dehydrogenase (20αHSD), an enzyme involved in P4 metabolism.…”

Section: Progesterone and Preterm Birthmentioning

confidence: 99%

“…In other words, under conditions of hyperinflammation, NF-κB/AP-1 pathways mediate an increase in the expression of 20α-Hydroxysteroid Dehydrogenase (20αHSD), an enzyme involved in P4 metabolism. This leads to enhanced intracellular metabolism of P4 and shedding of PR-B, culminating in functional progesterone withdrawal [ 99 ]. This may provide an explaination for understanding how inflammatory factors, such as TNF-α and IFN-γ, could stimulate myometrial contractions [ 33 ], which may be related with possibility to induce alterations in PR isoforms, thereby undermining the role of P4 in preserving the quiescent of myometrium.…”

Section: Progesterone and Preterm Birthmentioning

confidence: 99%

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Preterm birth, a consequence of immune deviation mediated hyperinflammation

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Zhang,

et al. 2024

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“…Here, we try to review the potential reason through which progesterone exerts its effects [ 22 , 99 ]. Progesterone have capability to control of myometrial contractility.…”

Section: Progesterone and Preterm Birthmentioning

confidence: 99%

Section: Progesterone and Preterm Birthmentioning

confidence: 99%

Section: Progesterone and Preterm Birthmentioning

confidence: 99%

Section: Progesterone and Preterm Birthmentioning

confidence: 99%

Section: Progesterone and Preterm Birthmentioning

confidence: 99%

See 3 more Smart Citations

Preterm birth, a consequence of immune deviation mediated hyperinflammation

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Zhang,

et al. 2024

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Hormones and the comparative physiology of parturition in mammals

Young,

Renfree,

Mesiano

et al. 2011

Hormones and Reproduction of Vertebrates

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Prediction of post-delivery hemoglobin levels with machine learning algorithms

Aghajanian,

Jafarabady,

Abbasi

et al. 2024

Sci Rep

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Predicting postpartum hemorrhage (PPH) before delivery is crucial for enhancing patient outcomes, enabling timely transfer and implementation of prophylactic therapies. We attempted to utilize machine learning (ML) using basic pre-labor clinical data and laboratory measurements to predict postpartum Hemoglobin (Hb) in non-complicated singleton pregnancies. The local databases of two academic care centers on patient delivery were incorporated into the current study. Patients with preexisting coagulopathy, traumatic cases, and allogenic blood transfusion were excluded from all analyses. The association of pre-delivery variables with 24-h post-delivery hemoglobin level was evaluated using feature selection with Elastic Net regression and Random Forest algorithms. A suite of ML algorithms was employed to predict post-delivery Hb levels. Out of 2051 pregnant women, 1974 were included in the final analysis. After data pre-processing and redundant variable removal, the top predictors selected via feature selection for predicting post-delivery Hb were parity (B: 0.09 [0.05–0.12]), gestational age, pre-delivery hemoglobin (B:0.83 [0.80–0.85]) and fibrinogen levels (B:0.01 [0.01–0.01]), and pre-labor platelet count (B*1000: 0.77 [0.30–1.23]). Among the trained algorithms, artificial neural network provided the most accurate model (Root mean squared error: 0.62), which was subsequently deployed as a web-based calculator: https://predictivecalculators.shinyapps.io/ANN-HB. The current study shows that ML models could be utilized as accurate predictors of indirect measures of PPH and can be readily incorporated into healthcare systems. Further studies with heterogenous population-based samples may further improve the generalizability of these models.

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Progesterone control of myometrial contractility

Cited by 3 publications

References 197 publications

Preterm birth, a consequence of immune deviation mediated hyperinflammation

Preterm birth, a consequence of immune deviation mediated hyperinflammation

Hormones and the comparative physiology of parturition in mammals

Prediction of post-delivery hemoglobin levels with machine learning algorithms

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