Progesterone, but not β-estradiol, enhances Porphyromonas gingivalis lipopolysaccharide-induced vascular endothelial growth factor-A expression in human THP-1 monocytes

Jitprasertwong, Paiboon; Chaisomboon, Niratcha; Jamdee, Kusuma

doi:10.1016/j.jds.2013.07.001

Cited by 3 publications

(3 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ultrapure LPS from Escherichia coli 0111.B4 (TLR4 agonist) and ultrapure LPS from P. gingivalis (TLR2 agonist) were purchased from Invivogen (San Diego, CA, USA). The concentrations of β‐estradiol (0.1–10 ng/mL) and progesterone (1–100 ng/mL) used in stimulation experiments were in a range of serum hormone levels during pregnancy and were based on our previous study applying a comparable experimental setup . It has been shown that 100 ng/mL of E. coli or P. gingivalis LPS is an optimal concentration used in stimulation experiments .…”

Section: Methodsmentioning

confidence: 99%

“…Interestingly, increased levels of both hormones in saliva have been found associated with the severity of gingival inflammation during pregnancy . Several biological mechanisms have been proposed to explain the pathobiology of the interaction between pregnancy and periodontal disease , including increased vascularity and vascular flow, cellular changes, alterations in oral biofilms and depression of the immune system . It has been postulated that the particularly high susceptibility to develop gingival inflammation during pregnancy is associated with qualitative deficiency of maternal immunity such as decreased function of neutrophils , reduced levels of cytokine production and impaired function of maternal T lymphocytes .…”

mentioning

confidence: 99%

See 1 more Smart Citation

Female sex hormones modulate Porphyromonas gingivalislipopolysaccharide‐induced Toll‐like receptor signaling in primary human monocytes

Jitprasertwong

Charadram

Kumphune

et al. 2015

J of Periodontal Research

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Female sex hormones modulate Porphyromonas gingivalislipopolysaccharide‐induced Toll‐like receptor signaling in primary human monocytes

Jitprasertwong

Charadram

Kumphune

et al. 2015

J of Periodontal Research

View full text Add to dashboard Cite

show abstract

“…2 While the pathogenesis of PGs is not entirely understood, estrogen and progesterone have been hypothesized to influence growth, perhaps by regulation of vascular endothelial growth factor (VEGF). 3,4 Though spontaneous regression of a PG is possible, they typically require procedural treatment that can be difficult for some patients to tolerate, especially young children and individuals with intellectual disabilities, procedural anxiety, or behavioral concerns. Traditional PG treatments include surgical excision, electrocautery, cryotherapy, and laser therapy, which can be costly, invasive, result in scarring, and require an office visit or operative suite setting.…”

mentioning

confidence: 99%

Topical corticosteroids for noninvasive treatment of pyogenic granulomas

Moustafa

Neale

Ostrowski

et al. 2021

Pediatric Dermatology

View full text Add to dashboard Cite

Children with autism spectrum disorder (ASD) can present with behaviors such as aggression, self-injury, or irritability, which can render traditional procedural interventions used in dermatology difficult or dangerous for the patient, caregiver, or practitioner. 1 Patients with ASD and other neurodevelopmental disorders who have difficulty tolerating procedures prompt consideration of different treatment approaches. 1 We present here the use of an ultrapotent topical steroid as an alternative treatment approach for a common pediatric dermatology presentation, pyogenic granuloma (PG). Alternative

show abstract

A Research of Pyogenic Granuloma Genesis Factor With Immunohistochemical Analysis

Park¹,

Lee²,

Tak³

et al. 2017

Journal of Craniofacial Surgery

View full text Add to dashboard Cite

Pyogenic granuloma (PG) is a type of vascular tumor for which the growth mechanism is poorly understood. Estrogen and progesterone may influence vascular malformations by increasing neovascularization in the lesions. Pregnancy tumor is a term for PG that occurs on the gingival mucosa of pregnant women in response to local irritation or injury. The etiology and pathogenesis of this phenomenon are not fully understood. Hormonal imbalance has been hypothesized to be responsible for the development of gingival hyper-reactive inflammatory responses. Moreover, it has been shown in vitro that the female sex hormone is a potential regulator of the production of several growth factors, such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor, and nerve growth factor, in various cell types. Epidermal growth factor receptor (EGFR) is also involved in a signaling cascade that influences proliferation and other tumor-promoting activities, as well as the responsiveness to chemotherapy. The aim of this study was to examine the relationship between PG pathogenesis and hormone imbalance in 21 patients. All specimens were analyzed by immunohistochemical staining with hematoxylin and eosin for the following hormones: estrogen receptor, progesterone receptor, VEGF, and EGFR. The analysis of the specimens showed that estrogen receptor and EGFR were not associated with PG, while VEGF was statistically related to PG. In addition, there was no significantly difference between sex, tumor location, or pregnancy. There are few studies about correlation between the pathogenesis of PG and sex hormones or growth factors demonstrated via immunohistochemical analysis. The results of this study indicate that estrogen and progesterone do not influence the pathogenesis of PG; however, VEGF may be associated with the pathogenesis of PG.

show abstract

Progesterone, but not β-estradiol, enhances Porphyromonas gingivalis lipopolysaccharide-induced vascular endothelial growth factor-A expression in human THP-1 monocytes

Cited by 3 publications

References 41 publications

Female sex hormones modulate Porphyromonas gingivalislipopolysaccharide‐induced Toll‐like receptor signaling in primary human monocytes

Female sex hormones modulate Porphyromonas gingivalislipopolysaccharide‐induced Toll‐like receptor signaling in primary human monocytes

Topical corticosteroids for noninvasive treatment of pyogenic granulomas

A Research of Pyogenic Granuloma Genesis Factor With Immunohistochemical Analysis

Contact Info

Product

Resources

About