Progesterone attenuates cocaine-induced responses

Quiñones-Jenab, Vanya; Jenab, Shirzad

doi:10.1016/j.yhbeh.2009.10.002

Cited by 50 publications

(41 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sex differences were previously reported in the effects of PRO on cocaine dependence in humans, with PRO producing greater effects in females than males (Fox et al, 2013; Evans and Foltin, 2006; for review, see Quinones-Jenab and Jenab, 2010). Animal work with exogenous PRO similarly showed greater effects in females than males (Anker et al, 2009; Zlebnik et al, 2014).…”

Section: Introductionmentioning

confidence: 95%

Sex differences in reinstatement of cocaine-seeking with combination treatments of progesterone and atomoxetine

Swalve

Smethells

Zlebnik

et al. 2016

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Two repurposed medications have been proposed to treat cocaine abuse. Progesterone, a gonadal hormone, and atomoxetine, a medication commonly used to treat attention deficit/hyperactivity disorder, have both been separately shown to reduce cocaine self-administration and reinstatement (i.e. relapse). The goal of the present study was to examine sex differences in the individual effects of PRO and ATO as well as the combination PRO+ATO treatment on cocaine (COC), caffeine (CAF), and/or cue-primed reinstatement of cocaine-seeking. Adult male and female Wistar rats lever-pressed under a FR 1 schedule for cocaine infusions (0.4 mg/kg/inf). After 14 sessions of stable responding in daily 2-h sessions, rats underwent a 21-day extinction period when no drug or drug-related stimuli were present. Rats were then separated into four groups that received PRO (0.5 mg/kg) alone (PRO+SAL), ATO (1.5 mg/kg) alone (VEH+ATO), control (VEH+SAL) or combination (PRO+ATO) treatments prior to the reinstatement condition. Reinstatement of cocaine-seeking to cues and/or drug injections of cocaine or caffeine was tested after extinction. During maintenance, females self-administered more cocaine than males, but no sex differences were seen during extinction. Females showed greater cocaine-seeking than males after a CAF priming injection. Individual treatment with ATO did not decrease reinstatement under any priming condition; however, the combination treatment decreased cocaine-seeking under the COC+CUES priming condition in males, and both PRO alone and the combination treatment decreased cocaine-seeking in the CAF+CUES condition in females. Overall, PRO alone was only effective in reducing reinstatement in females, while the combination treatment was consistently effective in reducing reinstatement in both sexes.

show abstract

Section: Introductionmentioning

confidence: 95%

Sex differences in reinstatement of cocaine-seeking with combination treatments of progesterone and atomoxetine

Swalve

Smethells

Zlebnik

et al. 2016

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

show abstract

“…Indeed, the use of progesterone as a therapeutic agent has been proposed especially in nicotine and cocaine female users (Lynch and Sofuoglu 2010;Quinones-Jenab and Jenab 2010).…”

Section: Impact Of Genes and Hormonesmentioning

confidence: 99%

Sex and Gender in Adverse Drug Events, Addiction, and Placebo

Franconi

Campesi

Occhioni

et al. 2012

Sex and Gender Differences in Pharmacology

View full text Add to dashboard Cite

Sex-gender-based differences in response to pharmaceutical treatments are still under evaluation but evidence already exists regarding the impact of sex-gender-related differences on drug safety profile, drug abuse/addiction, and placebo effects. For a number of drugs it is well recognized that a sex-gender dimorphic profile in terms of drug adverse effects exists and appears to be more frequent and severe in women than in men. However, it is not well known whether this is due to pharmacodynamic or pharmacokinetic differences. Indeed the optimization of therapy requires that attention is paid to single sex-gender. Numerous pharmacokinetic, pharmacodynamic, and sociocultural differences between women and men in drug abuse have been described. Here we focus on sex-gender differences in alcoholism and nicotine addiction. The relevance of sex and gender differences in addiction appear to be relevant. Specific programs aimed to address addicted women's specific needs (child care, pregnancy, housing, and violence and others) are recommended. Finally, this article discusses the possible effect of sex-gender on placebo response in the light of the more significant recent literature evidencing that studies are urgently required in order to better understand the role of sex-gender on placebo mechanism and its impact on randomized clinical trials outcomes.

show abstract

“…While estrogen has apparent potentiating effects on positive subjective effects of drugs in humans (Evans et al 2002, Sofuoglu et al 1999, Justice and de Wit 2000) and drug seeking in animals (Larson et al 2005, Becker 1990, Jackson et al 2006), P attenuates drug-related responses in both humans and animals (Anker and Carroll 2010, Quinones-Jenab and Jenab 2010, Evans and Foltin 2010, Evans and Foltin 2006, Evans et al 2002, Sofuoglu et al 1999, Sofuoglu et al 2002). In women, high endogenous levels of P were associated with lower cue- and stress-induced cocaine craving (Sinha et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Effects of combined exercise and progesterone treatments on cocaine seeking in male and female rats

2014

View full text Add to dashboard Cite

BACKGROUND Individually, both treatment with progesterone and concurrent access to an exercise wheel reduce cocaine self-administration under long-access conditions and suppress cocaine-primed reinstatement in female rats. In the present study, wheel running and progesterone (alone and combined) were assessed for their effects on reinstatement of cocaine-seeking primed by yohimbine, cocaine, and cocaine-paired cues. METHODS Male and female rats were implanted with an intravenous catheter and allowed to self-administer cocaine (0.4 mg/kg/inf, iv) during 6-h sessions for 10 days. Subsequently, the groups of male and female rats were each divided into 2 groups that were given concurrent access to either a locked or unlocked running wheel under extinction conditions for 14 days. Next, all 4 groups were tested in a within-subjects design for reinstatement of cocaine-seeking precipitated by separate administration of cocaine-paired stimuli, yohimbine, or cocaine; or the combination of yohimbine + cocaine-paired stimuli or cocaine + cocaine-paired stimuli. These priming conditions were tested in the presence of concurrent wheel access (W), pretreatment with progesterone (P), or both (W+P). RESULTS In agreement with previous results, females responded more for cocaine than males during maintenance. Additionally, concurrent wheel running attenuated extinction responding and cocaine-primed reinstatement in females but not males. Across all priming conditions, W+P reduced reinstatement compared to control conditions, and for cocaine-primed reinstatement in male rats, the combined W+P treatment was more effective than W or P alone. CONCLUSION Under certain conditions, combined behavioral (exercise) and pharmacological (progesterone) interventions were more successful at reducing cocaine-seeking behavior than either intervention alone.

show abstract

Progesterone attenuates cocaine-induced responses

Cited by 50 publications

References 109 publications

Sex differences in reinstatement of cocaine-seeking with combination treatments of progesterone and atomoxetine

Sex differences in reinstatement of cocaine-seeking with combination treatments of progesterone and atomoxetine

Sex and Gender in Adverse Drug Events, Addiction, and Placebo

Effects of combined exercise and progesterone treatments on cocaine seeking in male and female rats

Contact Info

Product

Resources

About