Progesterone at encoding predicts subsequent emotional memory

(2015) 'High estradiol levels improve false memory rates and meta-memory in highly schizotypal women.', Psychiatry research., 229 (3). pp. 708-714. Further information on publisher's website:https://doi.org/10.1016/j.psychres. 2015.08.016 Publisher's copyright statement: NOTICE: this is the author's version of a work that was accepted for publication in Psychiatry Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be re ected in this document. Changes may have been made to this work since it was submitted for publication. Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. AbstractOverconfidence in false memories is often found in patients with schizophrenia and healthy participants with high levels of schizotypy, indicating an impairment of meta-cognition within the memory domain. In general, cognitive control is suggested to be modulated by natural fluctuations in estrogen. However, whether estrogen exerts beneficial effects on metamemory has not yet been investigated. The present study sought to provide evidence that high levels of schizotypy are associated with increased false memory rates and overconfidence in false memories, and that these processes may be modulated by natural differences in estradiol levels. Using the Deese-Roediger-McDermott paradigm, it was found that highly schizotypal participants with high estradiol produced significantly fewer false memories than those with low estradiol. No such difference was found within the low schizotypy participants. Highly schizotypal participants with high estradiol were also less confident in their false memories than those with low estradiol; low schizotypy participants with high estradiol were more confident. However, these differences only approached significance. These findings suggest that the beneficial effect of estradiol on memory and meta-memory observed in healthy participants is specific to highly schizotypal individuals and might be related to individual differences in baseline dopaminergic activity.

show abstract

“…Because progesterone has been shown to influence memory process (Ertman et al, 2011), progesterone levels were included as a covariate.…”

Section: Discussionmentioning

confidence: 99%

High estradiol levels improve false memory rates and meta-memory in highly schizotypal women

Hodgetts

Hausmann

Weis

2015

Psychiatry Research

View full text Add to dashboard Cite

show abstract

“…Natural fluctuations in estradiol across the menstrual cycle are associated with fluctuations in verbal, emotional and spatial memory performance in some studies (Ertman et al, 2011;Solis-Ortiz and Corsi-Cabrera, 2008) in particular, menstrual cycle-dependent changes in verbal memory occurred simultaneously to changes in hippocampal volume (Protopopescu et al, 2008). However, others have failed to find such a correlation between fluctuations in hormone levels and memory (Phillips and Sherwin, 1992b;Resnick et al, 1998).…”

Section: Accepted Manuscriptmentioning

confidence: 95%

Structure–function–behavior relationship in estrogen-induced synaptic plasticity

Vierk

Bayer

Freitag

et al. 2015

Hormones and Behavior

View full text Add to dashboard Cite

“…High progesterone levels have been associated with enhanced memory for emotionally arousing stimuli in women (Ertman, Andreano, & Cahill, 2011). Endogenous progesterone levels also interact with stress exposure to regulate emotional memory.…”

Section: Gonadal Hormones Stress and Fear Extinctionmentioning

confidence: 99%

Sex differences in anxiety disorders: Interactions between fear, stress, and gonadal hormones

Maeng

Milad

2015

Hormones and Behavior

299

199

View full text Add to dashboard Cite

Women are more vulnerable to stress- and fear-based disorders, such as anxiety and post-traumatic stress disorder. Despite the growing literature on this topic, the neural basis of these sex differences remains unclear, and the findings appear inconsistent. The neurobiological mechanisms of fear and stress in learning and memory processes have been extensively studied, and the crosstalk between these systems is beginning to explain the disproportionate incidence and differences in symptomatology and remission within these psychopathologies. In this review, we discuss the intersect between stress and fear mechanisms and their modulation by gonadal hormones and discuss the relevance of this information to sex differences in anxiety and fear-based disorders. Understanding these converging influences is imperative to the development of more effective, individualized treatments that take sex and hormones into account.

show abstract

Progesterone at encoding predicts subsequent emotional memory

Cited by 83 publications

References 59 publications

High estradiol levels improve false memory rates and meta-memory in highly schizotypal women

High estradiol levels improve false memory rates and meta-memory in highly schizotypal women

Structure–function–behavior relationship in estrogen-induced synaptic plasticity

Sex differences in anxiety disorders: Interactions between fear, stress, and gonadal hormones

Contact Info

Product

Resources

About