Progesterone and progesterone receptors in reptiles

Custodia-Lora, Noemı́; Callard, İan P.

doi:10.1016/s0016-6480(02)00030-8

Cited by 59 publications

(30 citation statements)

References 51 publications

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“…Progesterone levels increase during gestation in a variety of vertebrates for the general purpose of preg nancy maintenance (Custodia-Lora and Callard, 2002). However, the exact role of P, as well as interspecific variation in this role, is not well understood.…”

Section: Discussionmentioning

confidence: 99%

“…maintain pregnancy in viviparous taxa (Custodia-Lora and Callard, 2002). The adrenal glucocorticoids (e.g., Steroid hormones regulate many physiological procorticosterone, B) are elevated during reproduction in cesses in vertebrates, including reproduction, growth, some species, acting to mobilize energy for costly reand homeostatic mechanisms such as water and energy productive behaviors (Moore and Jessop, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Seasonal steroid hormone levels and their relation to reproduction in the Western Diamond-backed Rattlesnake, Crotalus atrox (Serpentes: Viperidae)

Taylor

DeNardo

Jennings

2004

General and Comparative Endocrinology

106

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We report seasonal variation in steroid hormone levels in blood samples from free ranging Western Diamond backed Rattle snakes (Crotalus atrox), and the relationship between these hormones and events in the reproductive cycle. At a field site in the Sonoran Desert of south central Arizona, we collected monthly blood samples over the course of two active seasons from 17 ra diotelemetered females, and over three active seasons from 103 randomly encountered males. We used radioimmunoassay to measure plasma levels of 17b estradiol, progesterone, corticosterone, and testosterone in samples from females, and corticosterone and testosterone in samples from males. Non reproductive females have consistently low levels of circulating 17b estradiol, pro gesterone, and testosterone throughout the year. In reproductive females, 17b estradiol levels increase dramatically and testosterone levels increase modestly during vitellogenesis in April and May, while progesterone levels increase dramatically at ovulation in June and then steadily decline until parturition in August. Corticosterone levels appear relatively constant in non reproductive females, whereas reproductive females show increased levels at the end of gestation. Plasma testosterone levels in males are low in early summer and are elevated during spring and late summer, corresponding to the two mating periods of C. atrox. Plasma cortico sterone levels in males did not vary seasonally and were not related to testosterone levels.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Seasonal steroid hormone levels and their relation to reproduction in the Western Diamond-backed Rattlesnake, Crotalus atrox (Serpentes: Viperidae)

Taylor

DeNardo

Jennings

2004

General and Comparative Endocrinology

106

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“…Progesterone receptor concentrations in the oviduct and liver of P. sicula vary differentially across the reproductive cycle: in particular, PR is detectable by binding assays and western blotting in the liver during periods when vitellogenin (Vtg) is not being synthesized, and in the oviduct except during the passage of eggs (Paolucci & Di Cristo, 2002). Additionally, expression of PRB in the turtle ovary suggests a role for P 4 in the regulation of oocyte maturation in reptiles (Custodia-Lora & Callard, 2002). Two isoforms of PR, PRA and PRB, have been identified in both the oviduct and liver of C. picta (Giannoukos & Callard, 1995;1996).…”

Section: Tissue Receptorsmentioning

confidence: 99%

Hormonal Regulation of Ovarian Function in Reptiles

Jones

2011

Hormones and Reproduction of Vertebrates

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“…Recent studies identified a receptor for these steroids in the cell membrane (Zhu et al 2003a, 2003b), in addition to the traditional perinuclear receptor, which acts as a transcription factor (Carson-Jurica et al 1990). Some species can have more than one form of the perinuclear receptor with unique tissue distributions (Custodia-Lora and Callard 2002). Very few studies have examined the action of environmental contaminants on progestin-based phenomena.…”

Section: Glucocorticoids and Progestins: Steroid Actions Beyond Estromentioning

confidence: 99%

Endocrine Disrupting Contaminants—Beyond the Dogma

Guillette

2006

Environ Health Perspect

134

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Descriptions of endocrine disruption have largely been associated with wildlife and driven by observations documenting estrogenic, androgenic, antiandrogenic, and antithyroid actions. These actions, in response to exposure to ecologically relevant concentrations of various environmental contaminants, have now been established in numerous vertebrate species. However, many potential mechanisms and endocrine actions have not been studied. For example, the DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane] metabolite, p,p′-DDE [1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene] is known to disrupt prostaglandin synthesis in the uterus of birds, providing part of the explanation for DDT-induced egg shell thinning. Few studies have examined prostaglandin synthesis as a target for endocrine disruption, yet these hormones are active in reproduction, immune responses, and cardiovascular physiology. Future studies must broaden the basic science approach to endocrine disruption, thereby expanding the mechanisms and endocrine end points examined. This goal should be accomplished even if the primary influence and funding continue to emphasize a narrower approach based on regulatory needs. Without this broader approach, research into endocrine disruption will become dominated by a narrow dogma, focusing on a few end points and mechanisms.

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Progesterone and progesterone receptors in reptiles

Cited by 59 publications

References 51 publications

Seasonal steroid hormone levels and their relation to reproduction in the Western Diamond-backed Rattlesnake, Crotalus atrox (Serpentes: Viperidae)

Seasonal steroid hormone levels and their relation to reproduction in the Western Diamond-backed Rattlesnake, Crotalus atrox (Serpentes: Viperidae)

Hormonal Regulation of Ovarian Function in Reptiles

Endocrine Disrupting Contaminants—Beyond the Dogma

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