Progesterone acts at the plasma membrane of human sperm

Meizel, Stanley; Turner, Kenneth O.

doi:10.1016/0303-7207(91)90080-c

Cited by 167 publications

(85 citation statements)

References 18 publications

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“…An acrosome reaction can be induced by follicular fluid, cumulus cells (Tesarik et al, 1993), or zona pellucida (Cross et al, 1988). Progesterone (its receptor in spermatozoa has not yet been identified) is a major inducer of the acrosome reaction in follicular fluid (Meizel and Turner, 1991;Somanath et al, 2000). The antiprogestin RU486 {RU38486, mifepristone, 17β-hydroxy-11β-[4-(dimethylamino)phenyl]-17α-propynylestra-4,9-dien-3-one} binds with high affinity to the intracellular progesterone receptor in most vertebrate species (Baulieu, 1989).…”

Section: Introductionmentioning

confidence: 99%

RU486 Suppresses Progesterone-induced Acrosome Reaction in Boar Spermatozoa

Jang¹,

Yi²

2002

BMB Reports

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The effects of progesterone on the acrosome reaction, as well as the effects of RU486 on the progesterone-induced acrosome reaction in capacitated boar spermatozoa, were investigated. Progesterone, a major steroid that is secreted by the cumulus cells of oocyte, clearly induced the acrosome reaction in a dose-dependent manner in capacitated boar spermatozoa, even though it failed to show similar effects in non-capacitated spermatozoa. RU486, a potent antiprogestin, significantly reduced the effects of progesterone on the progesterone-induced acrosome reaction; however, when treated alone, it showed no inhibitory effects on the acrosome reaction. The inhibitory effects of RU486 were also shown to be dosedependent. These results imply that in addition to the wellknown inducer of the acrosome reaction, zona pellucida, progesterone can also induce the acrosome reaction through its specific receptors on spermatozoa after the spermatozoa undergo capacitation.

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Section: Introductionmentioning

confidence: 99%

RU486 Suppresses Progesterone-induced Acrosome Reaction in Boar Spermatozoa

Jang¹,

Yi²

2002

BMB Reports

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“…Progesterone induces AR in human sperm by interacting with a steroid receptor located in the plasma membrane. This membrane receptor is distinctly di erent from the classical nuclear receptor [4,22,26,30] and may be related to the GABA A receptor=Cl 7 channel [21].…”

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confidence: 99%

Biphasic Effect of GABA on Rat Sperm Acrosome Reaction: Involvement of GABA A and GABA B Receptors

et al. 2002

Archives of Andrology

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“…The sperm population reaching the oocyte has been in presence of high level of progesterone (1.0 µg/mL) during transit through the female reproductive tract [13]. Therefore, progesterone may play a role in selecting capacitated spermatozoa from the total population with fecundation capacity.…”

Section: H R Contreras Et Al H R Contreras Et Al H R Contreramentioning

confidence: 99%