Progestational agents and blood coagulation

Margulis, R.R.; Ambrus, Julian L.; Mink, Irving B.; Stryker, Joan C.

doi:10.1016/0002-9378(65)90653-8

Cited by 35 publications

(7 citation statements)

References 23 publications

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“…This is in general agreement with previous studies [12,22], although several groups [2,18] have found no alteration in prothrombin activity. Also A mbrus et al [1] reported factor V to be unaffected.…”

Section: Discussionsupporting

confidence: 83%

“…This was not confirmed in our series by either one-or two-stage assays. The lack of an effect on fibrinogen is in agreement with Margulis et al [18], and Sobrero et al [28], but in contradistinction to those of A mbrus et al [1], and Brakman and Astrup [7], Alterations in antithrombin III activity and antigen levels have both been suggested to predict those at risk from thrombosis [13,31]. However, we were unable to confirm a decrease in activity or antigen level.…”

Section: Discussionsupporting

confidence: 71%

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Changes in Coagulation Factors and Platelet Function in Response to Progestational Agents

McGrath¹,

Castaldi²

1975

Pathophysiol Haemos Thromb

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Levels of coagulation factors I, II, V, VII-X, VIII, IX, X, plasminogen and antithrombin III, were determined at midcycle in 17 test subjects using oral contraceptive agents, and in 10 control subjects. Immunoassay of factor II and antithrombin III was also carried out, and platelet aggregation quantitatively assessed. Significant increases were found in the activity of factors II, V, VII-X, X and plasminogen, but factor II antigen levels did not change. Platelet aggregation with collagen was significantly enhanced. No change occurred in antithrombin III activity or antigen levels.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 71%

Changes in Coagulation Factors and Platelet Function in Response to Progestational Agents

McGrath¹,

Castaldi²

1975

Pathophysiol Haemos Thromb

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“…Our results support the former conclusion. We were, however, unable to confirm previous reports that the platelet count is increased by oestrogen-progestogen preparations [19,20].…”

Section: Discussioncontrasting

confidence: 55%

“…In the present group of blood donors the fall in the level of «2-macroglobulin with increase in age in younger adults was also found, but there was a trend towards a rise in the small number of older men participating in the study. The rise in the «2-macroglobulin level in elderly subjects has been noted previously [12,19].…”

Section: Discussionmentioning

confidence: 79%

Interrelations between ABO Blood Group, Plasminogen, α<sub>1</sub>-Antitrypsin, α<sub>2</sub>-Macroglobulin and the Platelet Count in Blood Donors

Dawson¹,

Allardyce²,

Allan³

et al. 1976

Acta Haematol

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The levels of plasminogen, α₁-antitrypsin, α₂-macroglobulin and the platelet count were measured in 511 blood donors. The mean level of α₁-antitrypsin was significantly lower in men of group B compared with that of group O. No other differences between the blood groups reached statistical significance. Women had higher mean levels of α₁-antitrypsin and α₂-macroglobulin and a higher platelet count than men. The levels of plasminogen and α₁-antitrypsin were significantly higher in women using oral contraceptives compared with those who were not. The level of α₂-macroglobulin fell with age until the 60–64 year age-group in men and the 40–49 year age-group in women. A positive correlation existed between the α₁-antitrypsin and the α₂-macroglobulin level and between the platelet count and the plasminogen level.

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“…The effects of progestogens on hemostatic function seem to be minimal but cannot be ruled out completely [2][3]. The Norplant-2 rod system is a new long-acting subdermal implant system containing levonorgestrel and is currently undergoing clinical trials in Singapore and several other countries.…”

Section: Introductionmentioning

confidence: 97%

A three-year evaluation of hemostatic function in Singaporean Norplant-2 rod acceptors

1990

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A longitudinal study of hemostatic function was carried out on 100 Singaporean acceptors using Norplant-2 rods for contraception. The results at the end of three years indicate a possible increased predisposition to thrombosis, as evidenced by significant increases in platelet count and aggregability. The prothrombin time (PT) and activated partial thromboplastin time (APTT) continued to remain shortened at the end of three years of use. There was also a general fall in most of the vitamin K coagulation factors. There is thus still an indication of a possible enhanced potential for hypercoagulation at the end of three years of Norplant-2 rod use.

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Progestational agents and blood coagulation

Cited by 35 publications

References 23 publications

Changes in Coagulation Factors and Platelet Function in Response to Progestational Agents

Changes in Coagulation Factors and Platelet Function in Response to Progestational Agents

Interrelations between ABO Blood Group, Plasminogen, α<sub>1</sub>-Antitrypsin, α<sub>2</sub>-Macroglobulin and the Platelet Count in Blood Donors

A three-year evaluation of hemostatic function in Singaporean Norplant-2 rod acceptors

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